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Seattle Structural Genomics Center for Infectious Disease

AcbaC.00137.c: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase

Target Characteristics

from organism: Acinetobacter baumannii AB5075-UW
most recent status: in PDB
center reference id: AcbaC.00137.c
is community request: True
associated disease:
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
unclassified

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
AcbaC.00137.c.B1.GE38592 full length 1 466 GE38592
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Structures

image of structure for 4ZIY
4ZIY
Deposited: 4/28/2015
Determination: XRay
Diffraction Image
Clone: AcbaC.00137.c.B1.GE38592
Protein: AcbaC.00137.c.B1.PS02364

External Resources

Resource Reference ID
GenBank: AKA30071.1
PATRIC ID: fig|470.1345.peg.272
PGAT: acinetobacter:ABUW_0285
RefSeq: WP_000557513.1
UniProt: A0A0D5YEC3

Enzyme & Pathway Information

Pathway Pathway ID EC Number
peptidoglycan biosynthesis I (meso-diaminopimelate containing) PEPTIDOGLYCANSYN-PWY 6.3.2.10
peptidoglycan biosynthesis II (staphylococci) PWY-5265 6.3.2.10
peptidoglycan biosynthesis III (mycobacteria) PWY-6385 6.3.2.10
UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing) PWY-6386 6.3.2.10
UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing) PWY-6387 6.3.2.10
peptidoglycan biosynthesis V (beta-lactam resistance) PWY-6470 6.3.2.10
peptidoglycan biosynthesis IV (Enterococcus faecium) PWY-6471 6.3.2.10
UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing) PWY-7953 6.3.2.10

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MHTSTTSTVP LEPWTAQQLQ QATQGYWHKD QIPQTEIKRI LTDSRHAESG DAFLALKGER FDAHNFVAQV VANGCQVAIV ERPIDAEIAQ LVVADTRLAL GQLGAYRREQ NAQLKVIALT GSSGKTTTKE MLGSILSRLA PTLITRGNLN NDLGVPMMLL ELRKEHQYAV MELGANHQGE IDYTSKIVQP HVAGILNIGT AHLGEFGGRD GICRAKSEIY RHILPQGVAI VPQQDDFTAE IREAAKSHQI MSFGAGGDVF ATEIELLPQS ANFQLHTPQG SSFVRLPFAG EHNVQNATAA VAFALALGVS LEDIVKGLEQ AQGAKGRLNF IQKTPHLFID DTYNANPTSM RAAAQVLLQQ NGIKVMVMGD IGELGDSSWQ EHHDLGRDLA ELPLDHIVAV GQFASAALEG AGLHSTKLKA FQTQAEALPF LINLIQTHQP QSMSFLFKGS RFTHMETLMA DLMEKL

NT Sequence
ATGCATACTT CAACCACCAG TACCGTGCCT TTGGAACCGT GGACAGCTCA ACAATTACAA CAGGCAACAC AGGGTTACTG GCATAAAGAC CAGATCCCTC AAACTGAAAT TAAACGTATT TTGACTGACT CGCGTCATGC AGAAAGTGGG GATGCCTTTT TAGCACTAAA AGGTGAACGT TTCGACGCGC ATAATTTTGT CGCGCAAGTG GTTGCAAATG GTTGCCAAGT CGCTATTGTC GAGCGGCCTA TAGATGCAGA AATTGCTCAG CTTGTAGTTG CCGATACCCG TTTGGCTTTG GGGCAGCTTG GTGCGTATCG TCGTGAACAA AATGCTCAAT TGAAAGTAAT TGCTTTAACG GGCAGTAGTG GTAAAACCAC CACCAAAGAA ATGCTAGGAA GTATTTTGTC TCGTTTAGCA CCTACATTGA TTACCCGAGG CAATTTAAAT AATGACCTTG GTGTGCCGAT GATGTTGCTT GAGCTTCGAA AGGAGCATCA GTATGCGGTG ATGGAACTTG GTGCAAATCA TCAAGGTGAA ATTGATTACA CATCAAAAAT TGTTCAACCG CATGTTGCTG GCATTTTAAA TATTGGAACT GCTCATTTGG GTGAGTTCGG CGGGCGTGAT GGCATTTGCC GCGCTAAATC AGAAATCTAT CGCCATATTT TACCTCAGGG CGTTGCTATT GTTCCGCAAC AAGATGACTT TACCGCTGAG ATTCGTGAAG CAGCCAAAAG CCATCAAATC ATGAGCTTTG GTGCTGGTGG TGATGTCTTT GCTACAGAGA TTGAATTGTT GCCACAATCT GCCAATTTCC AGTTACATAC GCCTCAAGGT TCAAGTTTTG TAAGACTGCC GTTTGCGGGT GAGCACAATG TGCAAAACGC AACTGCAGCA GTAGCATTTG CTTTGGCGTT AGGTGTTAGC TTGGAAGATA TCGTAAAAGG TCTAGAGCAA GCACAAGGTG CAAAAGGTCG TTTGAATTTT ATTCAAAAAA CGCCTCATTT ATTTATTGAT GATACTTATA ACGCCAATCC AACATCTATG CGTGCTGCGG CACAAGTATT ACTTCAGCAA AATGGCATTA AAGTCATGGT GATGGGGGAT ATTGGGGAGT TAGGTGATAG CAGTTGGCAA GAACATCACG ATTTAGGTCG CGATCTTGCT GAGCTTCCTT TAGACCATAT TGTTGCAGTT GGGCAGTTTG CCTCAGCAGC TCTCGAAGGC GCAGGTCTTC ATTCTACTAA ATTGAAAGCA TTTCAGACTC AAGCTGAGGC GCTTCCATTT TTAATCAATC TAATCCAAAC ACATCAACCC CAGTCCATGA GTTTCCTGTT TAAAGGTTCT CGCTTTACTC ATATGGAAAC GTTGATGGCT GATTTGATGG AGAAACTTTA A

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