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Seattle Structural Genomics Center for Infectious Disease

AcbaC.00170.a: NADH-dependent enoyl-ACP reductase

Target Characteristics

from organism: Acinetobacter baumannii AB5075-UW
most recent status: in PDB
center reference id: AcbaC.00170.a
is community request: True
associated disease:
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
unclassified

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
AcbaC.00170.a.B1.GE38605 full length 1 267 GE38605
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
AcbaC.00170.a.B1.PW37673 full length 1 267

Structures

image of structure for 4ZJU
4ZJU
Deposited: 4/29/2015
Determination: XRay
Diffraction Image
Clone: AcbaC.00170.a.B1.GE38605
Protein: AcbaC.00170.a.B1.PW37673

Citations by Others

Structure and substrate specificity of ketoacylacyl carrier protein synthase III from Acinetobacter baumannii
WC Lee, MC Jeong, Y Lee, C Kwak- Molecular, 2018 - Wiley Online Library
cited by: 1 other
PDB: 4ZJU
A Novel Series of Enoyl Reductase Inhibitors Targeting the ESKAPE Pathogens, Staphylococcus aureus and Acinetobacter baumannii
J Kwon, T Mistry, J Ren, ME Johnson- Bioorganic & Medicinal, 2017 - Elsevier
cited by: 2 others
PDB: 4ZJU

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
GenBank: AKA33061.1
PATRIC ID: fig|470.1345.peg.3300
PGAT: acinetobacter:ABUW_3365
RefSeq: WP_002027450.1
UniProt: A0A077GA87

Enzyme & Pathway Information

Pathway Pathway ID EC Number
biotin biosynthesis I BIOTIN-BIOSYNTHESIS-PWY 1.3.1.9
fatty acid elongation -- saturated FASYN-ELONG-PWY 1.3.1.9
(5Z)-dodecenoate biosynthesis I PWY0-862 1.3.1.9
superpathway of fatty acid biosynthesis I (E. coli) PWY0-881 1.3.1.9
superpathway of fatty acid biosynthesis II (plant) PWY-5156 1.3.1.9
palmitate biosynthesis II (bacteria and plants) PWY-5971 1.3.1.9
cis-vaccenate biosynthesis PWY-5973 1.3.1.9
stearate biosynthesis II (bacteria and plants) PWY-5989 1.3.1.9
superpathway of mycolate biosynthesis PWY-6113 1.3.1.9
palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) PWY-6282 1.3.1.9
superpathway of unsaturated fatty acids biosynthesis (E. coli) PWY-6284 1.3.1.9
superpathway of fatty acids biosynthesis (E. coli) PWY-6285 1.3.1.9
8-amino-7-oxononanoate biosynthesis I PWY-6519 1.3.1.9
triclosan resistance PWY-7096 1.3.1.9
gondoate biosynthesis (anaerobic) PWY-7663 1.3.1.9
oleate biosynthesis IV (anaerobic) PWY-7664 1.3.1.9
(5Z)-dodecenoate biosynthesis II PWY-7858 1.3.1.9
mycolate biosynthesis PWYG-321 1.3.1.9

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MTQGLLAGKR FLIAGVASKL SIAYGIAQAL HREGAELAFT YPNEKLKKRV DEFAEQFGSK LVFPCDVAVD AEIDNAFAEL AKHWDGVDGV VHSIGFAPAH TLDGDFTDVT DRDGFKIAHD ISAYSFVAMA RAAKPLLQAR QGCLLTLTYQ GSERVMPNYN VMGMAKASLE AGVRYLASSL GVDGIRVNAI SAGPIRTLAA SGIKSFRKML DANEKVAPLK RNVTIEEVGN AALFLCSPWA SGITGEILYV DAGFNTVGMS QSMMDDE

NT Sequence
ATGACACAAG GACTTTTAGC AGGTAAACGC TTTTTGATTG CAGGCGTTGC TAGTAAATTA TCAATTGCTT ATGGTATTGC ACAAGCATTA CACCGTGAAG GTGCTGAGCT TGCATTTACT TATCCAAACG AAAAATTAAA AAAACGTGTA GATGAGTTTG CTGAGCAATT CGGTTCTAAG CTTGTGTTTC CATGTGATGT TGCCGTTGAT GCTGAAATTG ATAATGCATT TGCGGAACTT GCAAAACATT GGGACGGCGT AGATGGTGTT GTGCACTCAA TCGGCTTTGC ACCTGCACAC ACGCTTGATG GTGACTTCAC TGACGTGACT GACCGTGACG GTTTTAAAAT TGCTCATGAC ATTAGCGCAT ACAGCTTTGT TGCAATGGCA CGTGCTGCAA AACCTTTGTT ACAAGCTCGC CAAGGTTGTT TATTAACTTT GACTTACCAA GGTTCTGAGC GCGTTATGCC TAACTACAAC GTAATGGGTA TGGCAAAAGC TTCTTTAGAA GCTGGTGTTC GTTACTTGGC ATCAAGTTTG GGTGTTGACG GTATCCGTGT AAACGCAATT TCTGCGGGTC CAATTCGTAC TTTAGCTGCT TCTGGTATTA AATCTTTCCG TAAAATGTTA GATGCTAACG AAAAAGTTGC ACCGTTAAAG CGTAACGTAA CCATTGAAGA AGTGGGTAAT GCAGCGTTAT TCCTTTGCTC ACCTTGGGCT TCAGGTATTA CTGGTGAAAT TCTATATGTA GATGCTGGTT TCAATACTGT AGGTATGAGC CAATCTATGA TGGATGATGA ATAA

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