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Seattle Structural Genomics Center for Infectious Disease

AcbaC.17905.a: thiamine-monophosphate kinase

Target Characteristics

from organism: Acinetobacter baumannii AB5075-UW
most recent status: in PDB
center reference id: AcbaC.17905.a
is community request: True
associated disease:
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
unclassified

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
AcbaC.17905.a.B1.PW37686 full length 1 305

Structures

image of structure for 5CC8
5CC8
Deposited: 7/1/2015
Determination: XRay
Diffraction Image
Clone: AcbaC.17905.a.B1.GE38781
Protein: AcbaC.17905.a.B1.PW37686
image of structure for 5CM7
5CM7
Deposited: 7/16/2015
Determination: XRay
Diffraction Image
Clone: AcbaC.17905.a.B1.GE38781
Protein: AcbaC.17905.a.B1.PW37686
image of structure for 6MFM
6MFM
Deposited: 9/11/2018
Determination: XRay
Diffraction Image
Clone: AcbaC.17905.a.B1.GE38781
Protein: AcbaC.17905.a.B1.PW37686
image of structure for 5DD7
5DD7
Deposited: 8/24/2015
Determination: XRay
Diffraction Image
Clone: AcbaC.17905.a.B1.GE38781
Protein: AcbaC.17905.a.B1.PW37686

Publications by SSGCID

Crystal structures of thiamine monophosphate kinase from Acinetobacter baumannii in complex with substrates and products
Abendroth J, Dranow DM, Edwards TE, Lorimer DD, Sullivan A, Horanyi PS
Sci Rep - 2019
volume 9, pages 4392
PMID: 30867460; PMCID: PMC6416309
PDB: 5CC8, 5CM7, 5DD7, 6MFM

Citations by Others


This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
GenBank: AKA29887.1
PATRIC ID: fig|470.1345.peg.88
PGAT: acinetobacter:ABUW_0092
RefSeq: WP_000807403.1
UniProt: A0A0D5YC82

Enzyme & Pathway Information

Pathway Pathway ID EC Number
thiamine diphosphate biosynthesis II (Bacillus) PWY-6893 2.7.4.16
thiamine diphosphate biosynthesis I (E. coli) PWY-6894 2.7.4.16
superpathway of thiamine diphosphate biosynthesis II PWY-6895 2.7.4.16
thiamine salvage I PWY-6896 2.7.4.16
thiamine salvage II PWY-6897 2.7.4.16
superpathway of thiamine diphosphate biosynthesis I THISYN-PWY 2.7.4.16

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MAEFSIIDQY FNRQSHPDVA LGIGDDSALI TPPPNQQLVI CADTLVAGRH FPLETSPHAI GWKSVAVNLS DIAAMGAKPH SILLAISLPQ VDHEWLEGFS QGIYDCCNQF GVALIGGDTT QGPHLTITVT AMGWIETGKA VLRSGAKVGD YVCVSGQIGD AAYGLQHLGH SLQQRLDYPT PRCKLGEELK GLASSMIDVS DGLAQDLGHI LKASKVGARL ILEKLPVDPV LQQIEEQQRW QYALAGGDDY ELCFTITPQN YEKLLQKQLD VKITMIGQIV EQTKLTFEHL GSDYPLQIHG YQHFA

NT Sequence
ATGGCTGAGT TCTCAATTAT TGATCAATAC TTTAATCGTC AGTCACATCC TGACGTTGCG CTTGGTATTG GTGATGACTC AGCCTTAATT ACTCCCCCTC CAAATCAACA ACTGGTGATC TGTGCAGATA CACTTGTTGC TGGACGTCAC TTCCCTCTTG AAACCTCGCC CCATGCGATT GGCTGGAAAA GTGTTGCCGT AAATCTGTCT GATATTGCTG CAATGGGCGC CAAACCACAT AGTATTTTAC TTGCGATCAG CTTGCCTCAA GTTGACCATG AATGGCTTGA AGGATTTAGT CAGGGAATCT ATGACTGTTG TAATCAATTT GGAGTTGCCT TAATTGGCGG AGATACCACT CAAGGTCCAC ACCTCACCAT TACCGTCACG GCCATGGGCT GGATTGAAAC AGGAAAAGCT GTATTACGTT CAGGTGCTAA GGTCGGTGAT TATGTTTGTG TAAGTGGTCA GATTGGTGAT GCTGCTTATG GACTTCAGCA TTTAGGACAT TCTCTACAAC AAAGACTGGA CTATCCGACG CCACGTTGTA AGCTTGGAGA AGAGCTAAAA GGGCTCGCCT CTAGCATGAT CGATGTGTCA GATGGTTTAG CTCAAGATTT AGGACATATT TTAAAAGCGT CCAAGGTTGG AGCACGACTC ATCCTGGAAA AATTACCTGT CGATCCTGTA CTGCAACAAA TAGAAGAACA ACAACGTTGG CAATATGCCT TGGCAGGTGG TGATGACTAC GAATTATGTT TTACAATAAC ACCGCAAAAT TATGAAAAAC TTTTGCAAAA ACAACTAGAC GTTAAGATTA CAATGATCGG ACAGATCGTT GAGCAAACAA AACTAACTTT TGAGCATTTG GGTTCAGATT ACCCATTGCA AATTCATGGA TACCAACACT TTGCATAA

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