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Seattle Structural Genomics Center for Infectious Disease

AcbaC.18179.a: 3-hydroxy-3-methylglutaryl-CoA lyase (Hydroxymethylglutaryl-CoA lyase) (EC 4.1.3.4)

Target Characteristics

from organism: Acinetobacter baumannii AB5075-UW
most recent status: in PDB
center reference id: AcbaC.18179.a
is community request: True
associated disease:
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
unclassified

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
AcbaC.18179.a.B1.GE40979 full length 1 312 GE40979
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
AcbaC.18179.a.B1.PW38190 full length 1 312
AcbaC.18179.a.B1.PW38191 full length 1 312

Structures

image of structure for 6NDS
6NDS
Deposited: 12/14/2018
Determination: XRay
Diffraction Image
Clone: AcbaC.18179.a.B1.GE40979
Protein: AcbaC.18179.a.B1.PW38191

External Resources

Resource Reference ID
PATRIC ID: fig|470.1345.peg.2462
UniProt: A0A0D5YK08

Enzyme & Pathway Information

Pathway Pathway ID EC Number
L-leucine degradation I LEU-DEG2-PWY 4.1.3.4
mevalonate degradation PWY-5074 4.1.3.4
ketogenesis PWY66-367 4.1.3.4

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MTAFSDLLVV QEVSPRDGLQ IEPTWVPTDK KIDLINQLST MGFSRIEAGS FVSPKAIPNL RDGEEVFTGI TRHKDIIYVG LIPNLKGALR AVEANANELN LVLSASQTHN LANMRMTKAQ SFAGFTEIVE QLQGKTQFNG TVATTFGCPF EGKISEREVF SLVEHYLKLG IHNITLADTT GMANPVQVKR IVSHVLSLIS PEQLTLHFHN TRGLGLTNVL AAYEVGARRF DAALGGLGGC PFAPGASGNI CTEDLVNMCE EIGIPTTIDL DALIQLSRTL PALLGHDTPS QLAKAGRNTD LHPIPDYIKS LN

NT Sequence
atgacagcat tttccgactt acttgttgta caagaagtct ctccacgaga tggtttgcaa attgagccga cttgggtacc caccgataag aaaattgatt taattaatca attgtcgaca atgggtttct ctcgaattga agcagggtct tttgtctcgc caaaagcgat tccaaatttg agagatggtg aggaggtttt tacaggaatt acacgccata aagatattat ttatgtgggg ctaattccaa acttaaaagg cgcgcttcgg gcagtggaag ccaatgcaaa tgagttgaat cttgtcctct ctgctagcca aacccacaac cttgccaata tgcgtatgac taaagctcaa tcgtttgcgg gatttaccga aattgtggag caactacagg gtaaaacaca gtttaacgga actgttgcga caacgtttgg ctgtccattt gaaggtaaga ttagtgaaag ggaagtgttt agcctagttg agcactatct aaaactgggt attcataaca ttacactggc agataccact ggcatggcga acccagtgca agtgaaaaga attgtctctc acgttttatc gttaatttca cctgagcagt tgaccctaca ttttcataat acacgtggat tgggattaac taatgtttta gcagcttatg aggttggagc aagacggttt gatgctgcat tgggtggttt aggtgggtgc ccgtttgcac caggggcttc tggaaatatc tgtactgaag atttggtcaa tatgtgtgag gaaattggaa tacccaccac gattgattta gatgctctta ttcaactttc cagaacctta ccagctcttt tagggcatga cacgccaagc cagcttgcta aggcggggag aaatacagac ttgcatccta taccggatta tatcaaatca cttaattaa

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