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Seattle Structural Genomics Center for Infectious Disease

AccaA.00032.a: S-adenosyl-L-homocysteine hydrolase

Target Characteristics

from organism: Acanthamoeba castellanii
most recent status: in PDB
center reference id: AccaA.00032.a
is community request: True
associated disease: Amoebic keratitis and encephalomyelitis
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
I

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
AccaA.00032.a.B1.GE43119 full length 1 477 GE43119
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
AccaA.00032.a.B1.PW38644 full length 1 477
AccaA.00032.a.B1.PW38645 full length 1 477

Structures

image of structure for 6UK3
6UK3
Deposited: 10/4/2019
Determination: XRay
Diffraction Image
Clone: AccaA.00032.a.B1.GE43119
Protein: AccaA.00032.a.B1.PW38645

External Resources

Resource Reference ID
EuPathDB: AmoebaDB:ACA1_054200
UniProt: L8H6B5

Enzyme & Pathway Information

Pathway Pathway ID EC Number
L-methionine degradation I (to L-homocysteine) METHIONINE-DEG1-PWY 3.3.1.1
S-adenosyl-L-methionine cycle II PWY-5041 3.3.1.1
superpathway of L-methionine salvage and degradation PWY-5328 3.3.1.1
superpathway of L-cysteine biosynthesis (mammalian) PWY-6292 3.3.1.1

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MQTQTQTQPA GNAFQYEIRD ISLAEFGRKE INLAEHEMPG LMQTREKYGA EQPLKGVRLA GSLHMTIQTA VLIETLQALG ANVRWCSCNI FSTQDHAAAA IVAAGTPVFA WKGETLEEYW ECTWKTLLFP DDMGPQLIVD DGGDATLMVH RGFYAEDNPS ILDDDEGSEE LAIVNKLLKR IQKEKPGYWH KIVPELKGVS EETTTGVHRL YEMMKEGKLL FPALNVNDSV TKSKFDNVYG CRHSLVDAIM RATDVMLSGK VACVLGYGDV GKGSAESLKG QGARVVVTEV DPICALQACM AGYEVVRIED VLDKAEIFVT TTGNCDIIRI EHMEKMRHNA IVCNIGHFDN EIQVKALKEF PGIKRIEIKP QVDQFVFPDG HAIVLLAEGR LVNLGCATGH PSFVMSNSFT NQTLAQISLW KEKYELGVYT LPKKLDEEVA RLHLEKLGAK LTVLTDKQAK YLGIAKDGPY KPDHYRY

NT Sequence
atgcagaccc aaactcagac ccagcccgct ggcaatgcct tccagtacga aatcagggac atcagccttg ctgagttcgg tcgcaaggag atcaacctcg ctgagcacga gatgcccggt ctcatgcaga cgcgcgagaa gtacggcgct gagcagcccc tcaagggagt caggctcgcc ggttcgctcc acatgaccat ccagaccgcc gtcctcatcg agaccctcca ggccctcggt gccaacgtcc gttggtgctc gtgcaacatc ttctcgaccc aggaccacgc cgccgccgcc atcgtggccg ccggtacccc cgtcttcgcc tggaagggtg agaccctcga ggagtactgg gagtgcacct ggaagaccct cctcttcccc gacgacatgg gtccccagct catcgtcgac gatggtggtg atgccaccct catggtccac cgcggtttct acgctgagga caacccctcc attcttgatg acgacgaggg ttctgaggag ctcgccatcg tcaacaagct cctgaagcgc atccagaagg agaagcccgg ttactggcac aagatcgtcc ccgagctcaa gggtgtctcg gaggagacca ccaccggtgt ccaccgtctc tacgagatga tgaaggaggg caagctcctt ttccccgccc tcaacgtcaa cgactccgtg accaagtcca agttcgacaa cgtctacggt tgccgtcact cgctcgtcga cgccatcatg cgcgccaccg acgtgatgct ctccggcaag gtcgcctgcg tgctcggcta cggtgacgtc ggcaagggtt ccgctgagtc cctcaagggc cagggtgctc gcgtcgtcgt gactgaggtc gatcccatct gcgccctcca ggcctgcatg gctggctatg aggtggtccg cattgaggac gtgctcgaca aggccgagat cttcgtcacc accaccggca actgcgatat catccgcatt gagcacatgg agaagatgcg ccacaacgcc atcgtgtgca acatcggtca cttcgacaat gagatccagg tgaaggccct caaggagttc cccggtatca agaggatcga gatcaagcct caggtcgacc agttcgtctt ccccgacggc catgccatcg tcctcctcgc tgagggccgc ctcgtcaact tgggctgcgc caccggccac ccttcgttcg tgatgtcgaa ctcgttcacc aaccagaccc ttgctcagat ctccctctgg aaggagaagt acgagctggg cgtgtacacg ctccccaaga agctcgacga ggaagtcgct cgcctccacc tcgagaagct cggcgccaag ctcaccgtcc tcaccgacaa gcaggccaag tacctcggca tcgccaagga cggaccctac aagcccgacc actaccgcta ctaa

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