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Seattle Structural Genomics Center for Infectious Disease

AnphA.00817.a: enoyl-(acyl-carrier-protein) reductase

Target Characteristics

from organism: Anaplasma phagocytophilum HZ
most recent status: in PDB
center reference id: AnphA.00817.a
is community request: False
associated disease: Human granulocytic anaplasmosis
NIH risk group: 1
is select agent: False
NIH priority
pathogens category:
I

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
AnphA.00817.a.A1.GE26660 Full length( AnphA.00817.a ) 1 275 GE26660
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
AnphA.00817.a.A1.PS00247 Full length( AnphA.00817.a ) 1 275
AnphA.00817.a.A1.PS00248 Full length( AnphA.00817.a ) 1 275

Structures

image of structure for 3K2E
3K2E
Deposited: 9/30/2009
Determination: XRay
Diffraction Image
Clone: AnphA.00817.a.A1.GE26660
Protein: AnphA.00817.a.A1.PS00248
image of structure for 3K31
3K31
Deposited: 9/30/2009
Determination: XRay
Diffraction Image
Clone: AnphA.00817.a.A1.GE26660
Protein: AnphA.00817.a.A1.PS00248

Citations by Others

< i> Staphylococcus aureus FabI: Inhibition, Substrate Recognition, and Potential Implications for In Vivo Essentiality
J Schiebel, A Chang, H Lu, MV Baxter, PJ Tonge? - Structure, 2012 - Elsevier
cited by: 33 others
PDB: 3K2E
High-resolution structures of Thermus thermophilus enoyl-acyl carrier protein reductase in the apo form, in complex with NAD+ and in complex with NAD+ and triclosan
JM Otero, AJ Noel, P Guardado-Calvo? - Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2012 - scripts.iucr.org
cited by: 2 others
PDB: 3K2E, 3K31
Prediction of protein targets of kinetin using in silico and in vitro methods: a case study on spinach seed germination mechanism
SP Kumar, VR Parmar, YT Jasrai… - Journal of Chemical …, 2015 - Springer
cited by: 8 others
PDB: 3K31
Rare Sidechain Conformations in Proteins and DNA
BJ Hintze - 2015 - search.proquest.com
PDB: 3K31

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_130466
PATRIC ID: fig|212042.8.peg.508
RefSeq: YP_505073.1
UniProt: Q2GKM8

Enzyme & Pathway Information

Pathway Pathway ID EC Number
biotin biosynthesis I BIOTIN-BIOSYNTHESIS-PWY 1.3.1.9
fatty acid elongation -- saturated FASYN-ELONG-PWY 1.3.1.9
(5Z)-dodecenoate biosynthesis I PWY0-862 1.3.1.9
superpathway of fatty acid biosynthesis I (E. coli) PWY0-881 1.3.1.9
superpathway of fatty acid biosynthesis II (plant) PWY-5156 1.3.1.9
palmitate biosynthesis II (bacteria and plants) PWY-5971 1.3.1.9
cis-vaccenate biosynthesis PWY-5973 1.3.1.9
stearate biosynthesis II (bacteria and plants) PWY-5989 1.3.1.9
superpathway of mycolate biosynthesis PWY-6113 1.3.1.9
palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) PWY-6282 1.3.1.9
superpathway of unsaturated fatty acids biosynthesis (E. coli) PWY-6284 1.3.1.9
superpathway of fatty acids biosynthesis (E. coli) PWY-6285 1.3.1.9
8-amino-7-oxononanoate biosynthesis I PWY-6519 1.3.1.9
triclosan resistance PWY-7096 1.3.1.9
gondoate biosynthesis (anaerobic) PWY-7663 1.3.1.9
oleate biosynthesis IV (anaerobic) PWY-7664 1.3.1.9
(5Z)-dodecenoate biosynthesis II PWY-7858 1.3.1.9
mycolate biosynthesis PWYG-321 1.3.1.9

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MRTGMLMEGK KGVIIGVAND KSLAWGIAKA VCAQGAEVAL TYLSETFKKR VDPLAESLGV KLTVPCDVSD AESVDNMFKV LAEEWGSLDF VVHAVAFSDK NELKGRYVDT SLGNFLTSMH ISCYSFTYIA SKAEPLMTNG GSILTLSYYG AEKVVPHYNV MGVCKAALEA SVKYLAVDLG KQQIRVNAIS AGPVRTLASS GISDFHYILT WNKYNSPLRR NTTLDDVGGA ALYLLSDLGR GTTGETVHVD CGYHVVGMKS VDAPDISRVK GDHSV

NT Sequence
GTGCGTACCG GCATGCTCAT GGAAGGAAAA AAGGGAGTCA TCATTGGTGT AGCTAATGAT AAGTCCTTGG CGTGGGGCAT CGCGAAAGCT GTGTGTGCAC AGGGTGCCGA GGTTGCTCTT ACATATCTTT CGGAGACTTT TAAGAAAAGG GTAGATCCCC TTGCGGAGTC TCTAGGTGTT AAGTTGACGG TTCCGTGTGA TGTATCAGAT GCGGAATCTG TAGACAATAT GTTCAAAGTT CTTGCTGAGG AGTGGGGTAG TCTGGATTTT GTGGTCCACG CGGTTGCATT TTCCGATAAG AACGAGCTCA AGGGAAGGTA TGTTGATACT TCTCTGGGTA ACTTCCTGAC GTCGATGCAT ATATCGTGTT ATTCTTTTAC TTACATTGCG AGTAAAGCTG AGCCACTGAT GACCAATGGT GGCAGTATTT TGACTCTCTC TTATTACGGT GCTGAGAAGG TAGTGCCCCA TTACAATGTG ATGGGCGTGT GCAAGGCGGC CCTCGAGGCA AGTGTTAAAT ATTTGGCGGT TGATTTGGGT AAGCAGCAGA TAAGAGTTAA TGCTATTTCT GCGGGGCCTG TTAGAACTTT GGCGTCTTCT GGAATTAGTG ATTTTCATTA TATACTGACG TGGAATAAGT ATAATTCGCC GTTGAGGCGC AATACTACTC TTGATGATGT CGGGGGGGCT GCGTTATATC TGCTGAGTGA TTTGGGTAGA GGGACAACTG GTGAGACTGT GCATGTGGAT TGTGGGTACC ATGTGGTGGG GATGAAATCG GTTGATGCTC CTGACATAAG CCGGGTGAAA GGCGATCATA GCGTG

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