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Seattle Structural Genomics Center for Infectious Disease

AnphA.01233.a: O-methyltransferase family protein

Target Characteristics

from organism: Anaplasma phagocytophilum HZ
most recent status: in PDB
center reference id: AnphA.01233.a
is community request: True
associated disease: Human granulocytic anaplasmosis
NIH risk group: 1
is select agent: False
NIH priority
pathogens category:
I

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
AnphA.01233.a.B1.GE35906 full length 1 218 GE35906
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
AnphA.01233.a.B1.PS01686 full length 1 218

Structures

image of structure for 4OA5
4OA5
Deposited: 1/3/2014
Determination: XRay
Diffraction Image
Clone: AnphA.01233.a.B1.GE35906
Protein: AnphA.01233.a.B1.PS01685
image of structure for 4OA8
4OA8
Deposited: 1/3/2014
Determination: XRay
Diffraction Image
Clone: AnphA.01233.a.B1.GE35906
Protein: AnphA.01233.a.B1.PS01686
image of structure for 4PCA
4PCA
Deposited: 4/14/2014
Determination: XRay
Diffraction Image
Clone: AnphA.01233.a.B1.GE35906
Protein: AnphA.01233.a.B1.PS01686
image of structure for 4PCL
4PCL
Deposited: 4/15/2014
Determination: XRay
Diffraction Image
Clone: AnphA.01233.a.B1.GE35906
Protein: AnphA.01233.a.B1.PS01686

Publications by SSGCID

An O-Methyltransferase Is Required for Infection of Tick Cells by Anaplasma phagocytophilum.
Burkhardt NY, Edwards TE, Fairman JW, Felsheim RF, Herron MJ, Higgins L, Kurtti TJ, Markowski TW, Munderloh UG, Nelson CM, Oliver JD, Olivia Chavez AS
PLoS Pathog. - 2015
volume 11, issue 11, pages e1005248
PMID: 26544981; PMCID: PMC4636158
PDB: 4OA5, 4OA8, 4PCA, 4PCL

Citations by Others

Outer Membrane Protein OmpB Methylation May Mediate Bacterial Virulence
DCH Yang, AH Abeykoon, BE Choi, WM Ching- Trends in Biochemical, 2017 - Elsevier
PDB: 4OA5, 4OA8, 4PCA
Homo Multimer Protein Complexes
P Kangueane, C Nilofer- Protein-Protein and Domain-Domain Interactions, 2018 - Springer
PDB: 4PCA

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_128394
PATRIC ID: fig|212042.8.peg.630
RefSeq: YP_505174.1
UniProt: Q2GKC7

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MRNVSLSKQD EYLNKLFAVD TEGALKAHKT APSELRMAQL GTVEGQMLQL LIRMAGIHSI VEVGTCVGFS AICMAHALPS KGHIYTIEKD YENVVTANQN IVNCKLEDKI TVLHGEALAQ LNTLKEMAPF DMIFIDANKS SYLAYLNWAK MYIRKGGLIV ADNTFLFGSV FDEHPTEKVS SNAHASMRAF NDELANKEKY LSTIIPTSEG MMVSIKLT

NT Sequence
gtgcgcaatg tctctttaag caaacaagat gagtacctta ataagctttt tgctgtagat actgagggtg cattgaaggc gcataaaact gcaccttctg agttgcgtat ggcacaatta gggactgttg aaggacaaat gctacagctt ttaataagaa tggctggtat acattcaata gtcgaagtgg gtacttgtgt gggattttcc gcaatatgta tggcgcatgc cctgccttct aagggacata tatacacaat agagaaagat tacgaaaacg tagtgaccgc aaatcagaac atagtcaact gtaaactgga agataaaata acggtattgc atggtgaggc tttggcgcag ctaaacactt taaaggaaat ggctccattt gatatgatat ttatagatgc aaacaaatcc tcataccttg cttacttaaa ctgggctaaa atgtatataa ggaagggtgg cctcatagtt gctgataaca ccttcctctt tggcagcgta tttgatgagc acccaactga aaaagtttct agtaatgctc atgccagtat gcgagcgttt aatgacgaac tcgctaataa agaaaaatac ctctctacca ttatacctac tagcgaaggc atgatggtat cgataaagct cacatga

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