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Seattle Structural Genomics Center for Infectious Disease

AnphA.17239.a: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (IspH/LytB) (IspG/H)

Target Characteristics

from organism: Anaplasma phagocytophilum HZ
most recent status: selected
center reference id: AnphA.17239.a
is community request: False
associated disease: Human granulocytic anaplasmosis
NIH risk group: 1
is select agent: False
NIH priority
pathogens category:
I

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

External Resources

Resource Reference ID
OrthoMCL: OG5_130373
PATRIC ID: fig|212042.8.peg.403
RefSeq: YP_504986.1
UniProt: Q2GKW5

Enzyme & Pathway Information

Pathway Pathway ID EC Number
1.17.1.2
methylerythritol phosphate pathway I NONMEVIPP-PWY 1.17.7.4
superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) PWY-5121 1.17.7.4
isoprene biosynthesis I PWY-6270 1.17.7.4
superpathway of ergosterol biosynthesis II PWY-7156 1.17.7.4
taxadiene biosynthesis (engineered) PWY-7392 1.17.7.4
methylerythritol phosphate pathway II PWY-7560 1.17.7.4

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MHSNCNDVEV ILAQPRGFCA GVERAVAILD MVVDQYIASK EVYVLHEIVH NAYVVESFRK RNVKFVASLD EVPTGAVLVF SAHGVAKQVR AAAQERGLVV IDATCPLVTK VHLEIHRYNK NGYKIILIGH KGHREVEGSM GQIQSEVLLV QNVDDVYNLP VDAETKLAYV TQTTLSVDDT RVIVEALKTR FPDIVGPDLK DICYATQNRQ TAVKELASMV DVMLIMGGKN SSNTNRLLDL AKVRNPRSFL IGSYEDVDLS WFADTKKIGV TAGASAPAIL VEELLKYFSS KMNIKVSTMD GVRENIVFKL PNLNESSHSF SSDA

NT Sequence
ATGCATAGTA ACTGCAATGA CGTTGAGGTG ATTTTAGCGC AACCGCGAGG CTTTTGTGCC GGTGTGGAGA GAGCGGTAGC TATTCTTGAT ATGGTTGTTG ACCAGTATAT TGCTAGTAAA GAAGTTTACG TTCTGCATGA GATTGTCCAC AACGCCTATG TGGTGGAAAG TTTTAGAAAA AGAAACGTTA AGTTCGTAGC CTCACTTGAT GAAGTTCCTA CTGGAGCTGT TCTTGTGTTC AGTGCTCATG GTGTTGCAAA GCAAGTTCGT GCCGCAGCTC AGGAACGAGG CCTTGTGGTA ATTGATGCCA CCTGCCCACT CGTTACTAAG GTGCATCTTG AGATTCATAG ATACAATAAG AACGGGTACA AAATTATCCT AATAGGGCAT AAAGGACACA GAGAAGTTGA AGGTAGCATG GGGCAAATAC AGAGTGAAGT CCTGTTAGTA CAGAATGTTG ATGATGTGTA TAACCTACCG GTTGATGCCG AGACGAAACT TGCATATGTA ACTCAAACAA CCTTAAGTGT TGATGATACC AGGGTGATAG TTGAAGCGCT GAAGACTAGA TTTCCAGATA TTGTAGGACC TGACTTAAAA GACATATGTT ACGCAACTCA AAATAGGCAA ACTGCTGTAA AAGAGCTTGC CTCTATGGTT GATGTAATGC TAATCATGGG TGGTAAGAAC AGCTCTAACA CCAACAGACT GCTGGATCTT GCAAAAGTTC GCAATCCTCG TTCTTTTCTT ATAGGATCCT ACGAAGATGT AGACCTGAGT TGGTTTGCAG ATACTAAGAA AATAGGTGTC ACAGCAGGGG CGTCTGCTCC GGCCATTCTG GTTGAAGAGC TTTTAAAATA TTTTTCCTCT AAAATGAACA TAAAGGTGTC GACCATGGAT GGGGTACGGG AGAACATTGT CTTCAAACTA CCTAATTTGA ATGAAAGCTC TCACAGCTTC TCCAGTGACG CT

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