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Seattle Structural Genomics Center for Infectious Disease

AnphA.17240.a: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (IspG/GcpE) (IspG/H)

Target Characteristics

from organism: Anaplasma phagocytophilum HZ
most recent status: selected
center reference id: AnphA.17240.a
is community request: False
associated disease: Human granulocytic anaplasmosis
NIH risk group: 1
is select agent: False
NIH priority
pathogens category:
I

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

External Resources

Resource Reference ID
OrthoMCL: OG5_130276
PATRIC ID: fig|212042.8.peg.471
RefSeq: YP_505045.1
UniProt: Q2GKQ6

Enzyme & Pathway Information

Pathway Pathway ID EC Number
methylerythritol phosphate pathway II PWY-7560 1.17.7.1
methylerythritol phosphate pathway I NONMEVIPP-PWY 1.17.7.3
superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) PWY-5121 1.17.7.3
isoprene biosynthesis I PWY-6270 1.17.7.3
superpathway of ergosterol biosynthesis II PWY-7156 1.17.7.3
taxadiene biosynthesis (engineered) PWY-7392 1.17.7.3

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MRVSQAVRVG KVTIGGGHPV VVQSMALGGS GSFDRDMQEV LALAREGSEL VRVAINSDES IKVIPDMVDV LVKHGFDEKM IVGCGQYEVA RLLRDYPTCA AALGKIRINP GNIGFGDKRD KNFEEVIEFA IKNDIPVRIG VNWGSLDKVL VGKLMDDNAN LPVPESADVV KAKALVLSAI TSAKKAEGIG LPSNRIVLSC KVSKVRDLVA VYTALARQSN HALHLGLTEA GAGLKGVVSS VAGIAHLLIM GIGDTVRVSL TSLTREGRTE EVKVCKEILQ SLGLRYFTAQ STSCPGCNRT NFDVFQKLVS GVNKYMESNM EAWKKKYPGV VNMTVAVMGC VVNGPGESKH ANLGLSMPGK GEREVAAVYE DGSKLCTIQG ADILEQFLNI IESYIAKNYS

NT Sequence
ATGAGAGTAA GTCAAGCTGT AAGGGTTGGC AAGGTAACAA TTGGTGGTGG GCATCCGGTA GTGGTGCAAT CTATGGCTCT TGGGGGTTCC GGAAGTTTTG ATCGGGACAT GCAGGAAGTG CTAGCCCTTG CGAGAGAGGG GTCTGAGTTA GTTAGGGTGG CTATAAATTC TGATGAGTCT ATAAAAGTAA TTCCTGACAT GGTTGATGTG CTGGTAAAGC ATGGGTTCGA TGAGAAGATG ATCGTTGGAT GCGGTCAATA TGAAGTTGCT AGGCTTCTTA GAGATTATCC AACGTGTGCT GCTGCATTGG GGAAAATAAG AATCAATCCA GGTAATATAG GTTTTGGTGA TAAGAGGGAT AAGAACTTTG AGGAGGTTAT AGAATTCGCT ATAAAGAACG ATATTCCGGT GAGAATAGGG GTAAACTGGG GTAGTTTGGA CAAGGTTCTC GTTGGGAAGC TCATGGACGA TAATGCGAAT CTTCCGGTGC CAGAATCCGC GGATGTTGTT AAGGCAAAGG CTTTGGTGCT TTCTGCTATC ACGAGTGCGA AGAAAGCAGA GGGGATAGGT TTGCCTTCTA ATAGAATAGT ACTTTCGTGT AAAGTCAGCA AAGTGAGAGA TTTAGTGGCG GTATACACCG CTTTAGCTAG GCAAAGTAAT CATGCATTGC ATCTTGGGTT AACTGAAGCG GGAGCTGGGT TAAAAGGGGT TGTTAGCAGT GTTGCGGGTA TAGCTCATCT ATTGATTATG GGTATAGGTG ATACTGTGAG GGTATCGCTT ACTTCTCTTA CTAGAGAGGG TAGAACTGAG GAAGTAAAGG TATGTAAGGA GATTTTGCAA TCATTAGGAT TAAGATATTT TACAGCGCAG AGTACTTCCT GTCCGGGGTG TAATCGTACA AATTTTGATG TTTTTCAGAA GCTTGTTTCC GGGGTGAACA AGTATATGGA AAGTAACATG GAGGCTTGGA AGAAGAAGTA TCCGGGTGTT GTGAATATGA CAGTTGCGGT TATGGGATGT GTTGTTAATG GGCCTGGCGA GAGCAAACAT GCCAATCTAG GGCTTAGTAT GCCTGGTAAG GGAGAGCGAG AAGTGGCTGC GGTTTACGAG GATGGCAGCA AGTTATGTAC CATTCAAGGT GCTGACATAT TGGAGCAGTT TTTGAATATT ATTGAGTCTT ACATTGCAAA GAATTATAGC

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