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Seattle Structural Genomics Center for Infectious Disease

BecoA.18655.a: S protein (envelope protein S) (Spike glycoprotein)

Target Characteristics

from organism: Betacoronavirus Human betacoronavirus 2c EMC/2012
most recent status: in PDB
center reference id: BecoA.18655.a
is community request: True
associated disease: respiratory, GI infections
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
BecoA.18655.a.HN11.GE00553 Full length( BecoA.18655.a ) 17 748 GE00553
BecoA.18655.a.HN12.GE00554 Full length( BecoA.18655.a ) 28 748 GE00554
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
BecoA.18655.a.HN11.PD00485 Full length( BecoA.18655.a ) 17 748

Structures

image of structure for 6Q04
6Q04
Deposited: 8/1/2019
Determination: CryoEM
Clone: BecoA.18655.a.MV5.GE43560
Protein: BecoA.18655.a.MV5.PE00010
image of structure for 6Q05
6Q05
Deposited: 8/1/2019
Determination: CryoEM
Clone: BecoA.18655.a.MV5.GE43560
Protein: BecoA.18655.a.MV5.PE00010
image of structure for 6Q06
6Q06
Deposited: 8/1/2019
Determination: CryoEM
Clone: BecoA.18655.a.MV5.GE43560
Protein: BecoA.18655.a.MV5.PE00010
image of structure for 6Q07
6Q07
Deposited: 8/1/2019
Determination: CryoEM
Clone: BecoA.18655.a.MV5.GE43560
Protein: BecoA.18655.a.MV5.PE00010

Citations by Others


This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
UniProt: K0BRG7
ViPR: link

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MIHSVFLLMF LLTPTESYVD VGPDSVKSAC IEVDIQQTFF DKTWPRPIDV SKADGIIYPQ GRTYSNITIT YQGLFPYQGD HGDMYVYSAG HATGTTPQKL FVANYSQDVK QFANGFVVRI GAAANSTGTV IISPSTSATI RKIYPAFMLG SSVGNFSDGK MGRFFNHTLV LLPDGCGTLL RAFYCILEPR SGNHCPAGNS YTSFATYHTP ATDCSDGNYN RNASLNSFKE YFNLRNCTFM YTYNITEDEI LEWFGITQTA QGVHLFSSRY VDLYGGNMFQ FATLPVYDTI KYYSIIPHSI RSIQSDRKAW AAFYVYKLQP LTFLLDFSVD GYIRRAIDCG FNDLSQLHCS YESFDVESGV YSVSSFEAKP SGSVVEQAEG VECDFSPLLS GTPPQVYNFK RLVFTNCNYN LTKLLSLFSV NDFTCSQISP AAIASNCYSS LILDYFSYPL SMKSDLSVSS AGPISQFNYK QSFSNPTCLI LATVPHNLTT ITKPLKYSYI NKCSRLLSDD RTEVPQLVNA NQYSPCVSIV PSTVWEDGDY YRKQLSPLEG GGWLVASGST VAMTEQLQMG FGITVQYGTD TNSVCPKLEF ANDTKIASQL GNCVEYSLYG VSGRGVFQNC TAVGVRQQRF VYDAYQNLVG YYSDDGNYYC LRACVSVPVS VIYDKETKTH ATLFGSVACE HISSTMSQYS RSTRSMLKRR DSTYGPLQTP VGCVLGLVNS SLFVEDCKLP LGQSLCALPD TPSTLTPRSV RSVPGEMRLA SIAFNHPIQV DQLNSSYFKL SIPTNFSFGV TQEYIQTTIQ KVTVDCKQYV CNGFQKCEQL LREYGQFCSK INQALHGANL RQDDSVRNLF ASVKSSQSSP IIPGFGGDFN LTLLEPVSIS TGSRSARSAI EDLLFDKVTI ADPGYMQGYD DCMQQGPASA RDLICAQYVA GYKVLPPLMD VNMEAAYTSS LLGSIAGVGW TAGLSSFAAI PFAQSIFYRL NGVGITQQVL SENQKLIANK FNQALGAMQT GFTTTNEAFQ KVQDAVNNNA QALSKLASEL SNTFGAISAS IGDIIQRLDV LEQDAQIDRL INGRLTTLNA FVAQQLVRSE SAALSAQLAK DKVNECVKAQ SKRSGFCGQG THIVSFVVNA PNGLYFMHVG YYPSNHIEVV SAYGLCDAAN PTNCIAPVNG YFIKTNNTRI VDEWSYTGSS FYAPEPITSL NTKYVAPQVT YQNISTNLPP PLLGNSTGID FQDELDEFFK NVSTSIPNFG SLTQINTTLL DLTYEMLSLQ QVVKALNESY IDLKELGNYT YYNKWPWYIW LGFIAGLVAL ALCVFFILCC TGCGTNCMGK LKCNRCCDRY EEYDLEPHKV HVH

NT Sequence
ATGATACACT CAGTGTTTCT ACTGATGTTC TTGTTAACAC CTACAGAAAG TTACGTTGAT GTAGGGCCAG ATTCTGTTAA GTCTGCTTGT ATTGAGGTTG ATATACAACA GACTTTCTTT GATAAAACTT GGCCTAGGCC AATTGATGTT TCTAAGGCTG ACGGTATTAT ATACCCTCAA GGCCGTACAT ATTCTAACAT AACTATCACT TATCAAGGTC TTTTTCCCTA TCAGGGAGAC CATGGTGATA TGTATGTTTA CTCTGCAGGA CATGCTACAG GCACAACTCC ACAAAAGTTG TTTGTAGCTA ACTATTCTCA GGACGTCAAA CAGTTTGCTA ATGGGTTTGT CGTCCGTATA GGAGCAGCTG CCAATTCCAC TGGCACTGTT ATTATTAGCC CATCTACCAG CGCTACTATA CGAAAAATTT ACCCTGCTTT TATGCTGGGT TCTTCAGTTG GTAATTTCTC AGATGGTAAA ATGGGCCGCT TCTTCAATCA TACTCTAGTT CTTTTGCCCG ATGGATGTGG CACTTTACTT AGAGCTTTTT ATTGTATTCT AGAGCCTCGC TCTGGAAATC ATTGTCCTGC TGGCAATTCC TATACTTCTT TTGCCACTTA TCACACTCCT GCAACAGATT GTTCTGATGG CAATTACAAT CGTAATGCCA GTCTGAACTC TTTTAAGGAG TATTTTAATT TACGTAACTG CACCTTTATG TACACTTATA ACATTACCGA AGATGAGATT TTAGAGTGGT TTGGCATTAC ACAAACTGCT CAAGGTGTTC ACCTCTTCTC ATCTCGGTAT GTTGATTTGT ACGGCGGCAA TATGTTTCAA TTTGCCACCT TGCCTGTTTA TGATACTATT AAGTATTATT CTATCATTCC TCACAGTATT CGTTCTATCC AAAGTGATAG AAAAGCTTGG GCTGCCTTCT ACGTATATAA ACTTCAACCG TTAACTTTCC TGTTGGATTT TTCTGTTGAT GGTTATATAC GCAGAGCTAT AGACTGTGGT TTTAATGATT TGTCACAACT CCACTGCTCA TATGAATCCT TCGATGTTGA ATCTGGAGTT TATTCAGTTT CGTCTTTCGA AGCAAAACCT TCTGGCTCAG TTGTGGAACA GGCTGAAGGT GTTGAATGTG ATTTTTCACC TCTTCTGTCT GGCACACCTC CTCAGGTTTA TAATTTCAAG CGTTTGGTTT TTACCAATTG CAATTATAAT CTTACCAAAT TGCTTTCACT TTTTTCTGTG AATGATTTTA CTTGTAGTCA AATATCTCCA GCAGCAATTG CTAGCAACTG TTATTCTTCA CTGATTTTGG ATTACTTTTC ATACCCACTT AGTATGAAAT CCGATCTCAG TGTTAGTTCT GCTGGTCCAA TATCCCAGTT TAATTATAAA CAGTCCTTTT CTAATCCCAC ATGTTTGATT TTAGCGACTG TTCCTCATAA CCTTACTACT ATTACTAAGC CTCTTAAGTA CAGCTATATT AACAAGTGCT CTCGTCTTCT TTCTGATGAT CGTACTGAAG TACCTCAGTT AGTGAACGCT AATCAATACT CACCCTGTGT ATCCATTGTC CCATCCACTG TGTGGGAAGA CGGTGATTAT TATAGGAAAC AACTATCTCC ACTTGAAGGT GGTGGCTGGC TTGTTGCTAG TGGCTCAACT GTTGCCATGA CTGAGCAATT ACAGATGGGC TTTGGTATTA CAGTTCAATA TGGTACAGAC ACCAATAGTG TTTGCCCCAA GCTTGAATTT GCTAATGACA CAAAAATTGC CTCTCAATTA GGCAATTGCG TGGAATATTC CCTCTATGGT GTTTCGGGCC GTGGTGTTTT TCAGAATTGC ACAGCTGTAG GTGTTCGACA GCAGCGCTTT GTTTATGATG CGTACCAGAA TTTAGTTGGC TATTATTCTG ATGATGGCAA CTACTACTGT TTGCGTGCTT GTGTTAGTGT TCCTGTTTCT GTCATCTATG ATAAAGAAAC TAAAACCCAC GCTACTCTAT TTGGTAGTGT TGCATGTGAA CACATTTCTT CTACCATGTC TCAATACTCC CGTTCTACGC GATCAATGCT TAAACGGCGA GATTCTACAT ATGGCCCCCT TCAGACACCT GTTGGTTGTG TCCTAGGACT TGTTAATTCC TCTTTGTTCG TAGAGGACTG CAAGTTGCCT CTTGGTCAAT CTCTCTGTGC TCTTCCTGAC ACACCTAGTA CTCTCACACC TCGCAGTGTG CGCTCTGTTC CAGGTGAAAT GCGCTTGGCA TCCATTGCTT TTAATCATCC TATTCAGGTT GATCAACTTA ATAGTAGTTA TTTTAAATTA AGTATACCCA CTAATTTTTC CTTTGGTGTG ACTCAGGAGT ACATTCAGAC AACCATTCAG AAAGTTACTG TTGATTGTAA ACAGTACGTT TGCAATGGTT TCCAGAAGTG TGAGCAATTA CTGCGCGAGT ATGGCCAGTT TTGTTCCAAA ATAAACCAGG CTCTCCATGG TGCCAATTTA CGCCAGGATG ATTCTGTACG TAATTTGTTT GCGAGCGTGA AAAGCTCTCA ATCATCTCCT ATCATACCAG GTTTTGGAGG TGACTTTAAT TTGACACTTC TAGAACCTGT TTCTATATCT ACTGGCAGTC GTAGTGCACG TAGTGCTATT GAGGATTTGC TATTTGACAA AGTCACTATA GCTGATCCTG GTTATATGCA AGGTTACGAT GATTGCATGC AGCAAGGTCC AGCATCAGCT CGTGATCTTA TTTGTGCTCA ATATGTGGCT GGTTACAAAG TATTACCTCC TCTTATGGAT GTTAATATGG AAGCCGCGTA TACTTCATCT TTGCTTGGCA GCATAGCAGG TGTTGGCTGG ACTGCTGGCT TATCCTCCTT TGCTGCTATT CCATTTGCAC AGAGTATCTT TTATAGGTTA AACGGTGTTG GCATTACTCA ACAGGTTCTT TCAGAGAACC AAAAGCTTAT TGCCAATAAG TTTAATCAGG CTCTGGGAGC TATGCAAACA GGCTTCACTA CAACTAATGA AGCTTTTCAG AAGGTTCAGG ATGCTGTGAA CAACAATGCA CAGGCTCTAT CCAAATTAGC TAGCGAGCTA TCTAATACTT TTGGTGCTAT TTCCGCCTCT ATTGGAGACA TCATACAACG TCTTGATGTT CTCGAACAGG ACGCCCAAAT AGACAGACTT ATTAATGGCC GTTTGACAAC ACTAAATGCT TTTGTTGCAC AGCAGCTTGT TCGTTCCGAA TCAGCTGCTC TTTCCGCTCA ATTGGCTAAA GATAAAGTCA ATGAGTGTGT CAAGGCACAA TCCAAGCGTT CTGGATTTTG CGGTCAAGGC ACACATATAG TGTCCTTTGT TGTAAATGCC CCTAATGGCC TTTACTTCAT GCATGTTGGT TATTACCCTA GCAACCACAT TGAGGTTGTT TCTGCTTATG GTCTTTGCGA TGCAGCTAAC CCTACTAATT GTATAGCCCC TGTTAATGGC TACTTTATTA AAACTAATAA CACTAGGATT GTTGATGAGT GGTCATATAC TGGCTCGTCC TTCTATGCAC CTGAGCCCAT TACCTCCCTT AATACTAAGT ATGTTGCACC ACAGGTGACA TACCAAAACA TTTCTACTAA CCTCCCTCCT CCTCTTCTCG GCAATTCCAC CGGGATTGAC TTCCAAGATG AGTTGGATGA GTTTTTCAAA AATGTTAGCA CCAGTATACC TAATTTTGGT TCCCTAACAC AGATTAATAC TACATTACTC GATCTTACCT ACGAGATGTT GTCTCTTCAA CAAGTTGTTA AAGCCCTTAA TGAGTCTTAC ATAGACCTTA AAGAGCTTGG CAATTATACT TATTACAACA AATGGCCGTG GTACATTTGG CTTGGTTTCA TTGCTGGGCT TGTTGCCTTA GCTCTATGCG TCTTCTTCAT ACTGTGCTGC ACTGGTTGTG GCACAAACTG TATGGGAAAA CTTAAGTGTA ATCGTTGTTG TGATAGATAC GAGGAATACG ACCTCGAGCC GCATAAGGTT CATGTTCAC

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