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Seattle Structural Genomics Center for Infectious Disease

BecoC.18655.a: S protein

Target Characteristics

from organism: Betacoronavirus MERS-related coronavirus
most recent status: in PDB
center reference id: BecoC.18655.a
is community request: False
associated disease:
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

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Structures

image of structure for 6NB3
6NB3
Deposited: 12/6/2018
Determination: CryoEM
Clone: BecoC.18655.a.MG1.GE42876
Protein: BecoC.18655.a.MG1.PE00003
image of structure for 6NB4
6NB4
Deposited: 12/6/2018
Determination: CryoEM
Clone: BecoC.18655.a.MG1.GE42876
Protein: BecoC.18655.a.MG1.PE00003

Publications by SSGCID

Unexpected receptor functional mimicry elucidates activation of coronavirus fusion
Tortorici MA, Snijder J, Walls AC, Rey FA, Veesler D, Xiong X, Park YJ, Quisp J, Cameroni E, Gopal R, Dai M, Lanzavecchia A, Zambon M, Corti D
Cell - 2019
volume 176, issue 5, pages 1026-1039
PMID: 30712865; PMCID: PMC6751136
PDB: 6NB3, 6NB4, 6NB5, 6NB6, 6NB7, 6NB8

Citations by Others

Molecular mechanism for antibody-dependent enhancement of coronavirus entry
Y Wan, J Shang, S Sun, W Tai, J Chen, Q Geng- Journal of, 2019 - Am Soc Microbiol
PDB: 6NB4

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
UniProt: A0A0G4AKW3
ViPR: link

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MIHSVFLLMF LLTPTESYVD VGPDSVKSAC IEVDIQQTFF DKTWPRPIDV SKADGIIYPQ GRTYSNITIT YQGLFPYQGD HGDMYVYSAG HATGTTPQKL FVANYSQDVK QFANGFVVRI GAAANSTGTV IISPSTSATI RKIYPAFMLG SSVGNFSDGK MGRFFNHTLV LLPDGCGTLL RAFYCILEPR SGNHCPAGNS YTSFATYHTP ATDCSDGNYN RNASLNSFKE YFNLRNCTFM YTYNITEDEI LEWFGITQTA QGVHLFSSRY VDLYGGNMFQ FATLPVYDTI KYYSIIPHSI RSIQSDRKAW AAFYVYKLQP LTFLLDFSVD GYIRRAIDCG FNDLSQLHCS YESFDVESGV YSVSSFEAKP SGSVVEQAEG VECDFSPLLS GTPPQVYNFK RLVFTNCNYN LTKLLSLFSV NDFTCSQISP AAIASNCYSS LILDYFSYPL SMKSDLSVSS AGPISQFNYK QSFSNPTCLI LATVPHNLTT ITKPLKYSYI NKCSRLLSDD RTELPQLVNA NQYSPCVSIV PSTVWEDGDY YRKQLSPLEG GGWLVASGST VAMTEQLQMG FGITVQYGTD TNSVCPKLEF ANDTKIASQL GNCVEYSLYG VSGRGVFQNC TAVGVRQQRF VYDAYQNLVG YYSDDGNYYC LRACVSVPVS VIYDKETKTH ATLFGSVACE HISSTMSQYS RSTRSMLKRR DSTYGPLQTP VGCVLGLVNS SLFVEDCKLP LGQSLCALPD TPSTLTPRSV RSVPGEMRLA SIAFNHPIQV DQLNSSYFKL SIPTNFSFGV TQEYIQTTIQ KVTVDCKQYI CNGFQKCEQL LREYGQFCSK INQALHGANL RQDDSVRNLF ASVKSSQSSP IIPGFGGDFN LTLLEPVSIS TGSRSARSAI EDLLFDKVTI ADPGYMQGYD DCMQQGPASA RDLICAQYVA GYKVLPPLMD VNMEAAYTSS LLGSIAGVGW TAGLSSFAAI PFAQSIFYRL NGVGITQQVL SENQKLIANK FNQALGAMQT GFTTTNEAFR KVQDAVNNNA QALSKLASEL SNTFGAISAS IGDIIQRLDV LEQDAQIDRL INGRLTTLNA FVAQQLVRSE SAALSAQLAK DKVNECVKAQ SKRSGFCGQG THIVSFVVNA PNGLYFMHVG YYPSNHIEVV SAYGLCDVAN PTNCIAPVNG YFIKTNNTRI VDEWSYTGSS FYSPEPITSL NTKYVAPQVT YQNISTNLPP PLLGNSTGID FQDELDEFFK NFSTSIPNFG SLTQINTTLL DLTYEMLSLQ QVVKALNESY IDLKELGNYT YYNKWPWYIW LGFIAGLVAL ALCVFFILCC TGCGTNCMGK LKCNRCCDRY EEYDLEPHKV HVH

NT Sequence
ATGATACACT CAGTGTTTCT ACTGATGTTC TTGTTAACAC CTACAGAAAG TTACGTTGAT GTAGGGCCAG ATTCTGTTAA GTCTGCTTGT ATTGAGGTTG ATATACAACA GACTTTCTTT GATAAAACTT GGCCTAGGCC AATTGATGTT TCTAAGGCTG ACGGTATTAT ATACCCTCAA GGCCGTACAT ATTCTAACAT AACTATCACT TATCAAGGTC TTTTTCCCTA TCAGGGAGAC CATGGTGATA TGTATGTTTA CTCTGCAGGA CATGCTACAG GCACAACTCC ACAAAAGTTG TTTGTAGCTA ACTATTCTCA GGACGTCAAA CAGTTTGCTA ATGGGTTTGT CGTCCGTATA GGAGCAGCTG CCAATTCCAC TGGCACTGTT ATTATTAGCC CATCTACCAG CGCTACTATA CGAAAAATTT ACCCTGCTTT TATGCTGGGT TCTTCAGTTG GTAATTTCTC AGATGGTAAA ATGGGCCGCT TCTTCAATCA TACTCTAGTT CTTTTGCCCG ATGGATGTGG CACTTTACTT AGAGCTTTTT ATTGTATTCT AGAGCCTCGC TCTGGAAATC ATTGTCCTGC TGGCAATTCC TATACTTCTT TTGCCACTTA TCACACTCCT GCAACAGATT GTTCTGATGG CAATTACAAT CGTAATGCCA GTCTAAACTC TTTTAAGGAG TATTTTAATT TACGTAACTG CACCTTTATG TACACTTATA ACATTACCGA AGATGAGATT TTAGAGTGGT TTGGCATTAC ACAAACTGCT CAAGGTGTTC ACCTCTTCTC ATCTCGGTAT GTTGATTTGT ACGGCGGCAA TATGTTTCAA TTTGCCACCT TGCCTGTTTA TGATACTATT AAGTATTACT CTATCATTCC TCACAGTATT CGTTCTATCC AAAGTGATAG AAAAGCTTGG GCTGCCTTCT ACGTATATAA ACTTCAACCG TTAACTTTCC TGTTGGATTT TTCTGTTGAT GGTTATATAC GCAGAGCTAT AGACTGTGGT TTTAATGATT TGTCACAACT CCACTGCTCA TATGAATCCT TCGATGTTGA ATCTGGAGTT TATTCAGTTT CGTCTTTCGA AGCAAAACCT TCTGGCTCAG TTGTGGAACA GGCTGAAGGT GTTGAATGTG ATTTTTCACC TCTTCTGTCT GGCACACCTC CTCAGGTTTA TAATTTCAAG CGTTTGGTTT TTACCAATTG CAATTATAAT CTTACCAAAT TGCTTTCACT TTTTTCTGTG AATGATTTTA CTTGTAGTCA AATATCTCCA GCAGCAATTG CTAGCAACTG TTATTCTTCA CTGATTTTGG ATTACTTTTC ATACCCACTT AGTATGAAAT CCGATCTCAG TGTTAGTTCT GCTGGTCCAA TATCCCAGTT TAATTATAAA CAGTCCTTTT CTAATCCCAC ATGTTTGATT TTAGCGACTG TTCCTCATAA CCTTACTACT ATTACTAAGC CTCTTAAGTA CAGCTATATT AACAAGTGCT CTCGTCTTCT TTCTGATGAT CGTACTGAAT TACCTCAGTT AGTGAACGCT AATCAATACT CACCCTGTGT ATCCATTGTC CCATCCACTG TGTGGGAAGA CGGTGATTAT TATAGGAAAC AACTATCTCC ACTTGAAGGT GGTGGCTGGC TTGTTGCTAG TGGCTCAACT GTTGCCATGA CTGAGCAATT ACAGATGGGC TTTGGTATTA CAGTTCAATA TGGTACAGAC ACCAATAGTG TTTGCCCCAA GCTTGAATTT GCTAATGACA CAAAAATTGC CTCTCAATTA GGCAATTGCG TGGAATATTC CCTCTATGGT GTTTCGGGCC GTGGTGTTTT TCAGAATTGC ACAGCTGTAG GTGTTCGACA GCAGCGCTTT GTTTATGATG CGTACCAGAA TTTAGTTGGC TATTATTCTG ATGATGGCAA CTACTACTGT TTGCGTGCTT GTGTTAGTGT TCCTGTTTCT GTCATCTATG ATAAAGAAAC TAAAACCCAC GCTACTCTAT TTGGTAGTGT TGCATGTGAA CACATTTCTT CTACCATGTC TCAATACTCC CGTTCTACGC GATCAATGCT TAAACGGCGA GATTCTACAT ATGGCCCCCT TCAGACACCT GTTGGTTGTG TCCTAGGACT TGTTAATTCC TCTTTGTTCG TAGAGGACTG CAAGTTGCCT CTCGGTCAAT CTCTCTGTGC TCTTCCTGAC ACACCTAGTA CTCTTACACC TCGCAGTGTG CGCTCTGTTC CAGGTGAAAT GCGCTTGGCA TCCATTGCTT TTAATCATCC CATTCAGGTT GATCAACTTA ATAGTAGTTA TTTTAAATTA AGTATACCCA CTAATTTTTC CTTTGGTGTG ACTCAGGAGT ACATTCAGAC AACCATTCAG AAAGTTACTG TTGATTGTAA ACAGTACATT TGCAATGGTT TCCAGAAGTG TGAGCAATTA CTGCGCGAGT ATGGCCAGTT TTGTTCCAAA ATAAACCAGG CTCTCCATGG TGCCAATTTA CGCCAGGATG ATTCTGTACG TAATTTGTTT GCGAGCGTGA AAAGCTCTCA ATCATCTCCT ATCATACCAG GTTTTGGAGG TGACTTTAAT TTGACACTTC TAGAACCTGT TTCTATATCT ACTGGCAGTC GTAGTGCACG TAGTGCTATT GAGGATTTGC TATTTGACAA AGTCACTATA GCTGATCCTG GTTATATGCA AGGTTACGAT GATTGTATGC AGCAAGGTCC AGCATCAGCT CGTGATCTTA TTTGTGCTCA ATATGTGGCT GGTTATAAAG TATTACCTCC TCTTATGGAT GTTAATATGG AAGCCGCGTA TACTTCATCT TTGCTTGGCA GCATAGCAGG TGTTGGCTGG ACTGCTGGCT TATCCTCCTT TGCTGCTATT CCATTTGCAC AGAGTATCTT TTATAGGTTA AACGGTGTTG GCATTACTCA ACAGGTTCTT TCAGAGAACC AAAAGCTTAT TGCCAATAAG TTTAATCAGG CTCTGGGAGC TATGCAAACA GGCTTCACTA CAACTAATGA AGCTTTTCGG AAGGTTCAGG ATGCTGTGAA CAACAATGCA CAGGCTCTAT CCAAATTAGC TAGCGAGCTA TCTAATACTT TTGGTGCTAT TTCCGCTTCT ATTGGAGACA TCATACAACG TCTTGATGTT CTCGAACAGG ACGCCCAAAT AGACAGACTT ATTAATGGCC GTTTGACAAC ACTAAATGCT TTTGTTGCAC AGCAGCTTGT TCGTTCCGAA TCAGCTGCTC TTTCCGCTCA ATTGGCTAAA GATAAAGTCA ATGAGTGTGT CAAGGCACAA TCCAAGCGTT CTGGATTTTG CGGTCAAGGC ACACATATAG TGTCCTTTGT TGTAAATGCC CCTAATGGCC TTTACTTCAT GCATGTTGGT TATTACCCTA GCAACCACAT TGAGGTTGTT TCTGCTTATG GTCTTTGCGA TGTAGCTAAC CCTACTAATT GTATAGCCCC TGTTAATGGC TACTTTATTA AAACTAATAA CACTAGGATT GTTGATGAGT GGTCATATAC TGGCTCGTCC TTCTATTCAC CTGAGCCCAT CACCTCCCTT AATACTAAGT ATGTTGCACC ACAGGTGACA TACCAAAACA TTTCTACTAA CCTCCCTCCT CCTCTTCTCG GCAATTCCAC CGGGATTGAC TTCCAAGATG AGTTGGATGA GTTTTTCAAA AATTTTAGCA CCAGTATACC TAATTTTGGT TCTCTAACAC AGATTAATAC TACATTACTC GATCTTACCT ACGAGATGTT GTCTCTTCAA CAAGTTGTTA AAGCCCTTAA TGAGTCTTAC ATAGACCTTA AAGAGCTTGG CAATTATACT TATTACAACA AATGGCCGTG GTACATTTGG CTTGGTTTTA TTGCTGGGCT TGTTGCCTTA GCTCTATGCG TCTTCTTCAT ACTGTGCTGC ACTGGTTGTG GCACAAACTG TATGGGAAAA CTTAAGTGTA ATCGTTGTTG TGATAGATAC GAGGAATACG ACCTCGAGCC GCATAAGGTT CATGTTCAC

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