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Seattle Structural Genomics Center for Infectious Disease

BewuA.18655.a: Spike glycoprotein (S)

Target Characteristics

from organism: Betacoronavirus SARS-CoV-2 (2019-nCoV) (COVID-19) isolate Wuhan-Hu-1
most recent status: in PDB
center reference id: BewuA.18655.a
is community request: False
associated disease:
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

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Structures

image of structure for 6VXX
6VXX
Deposited: 2/25/2020
Determination: CryoEM
Clone: BewuA.18655.a.MG1.GE43647
Protein: BewuA.18655.a.MG1.PE00013
image of structure for 6VYB
6VYB
Deposited: 2/25/2020
Determination: CryoEM
Clone: BewuA.18655.a.MG1.GE43647
Protein: BewuA.18655.a.MG1.PE00013

Molecular models

Method Results
comparative modelling Robetta_15652

Publications by SSGCID

Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein
Wall A, Tortorici MA, Walls AC, McGuire AT, Veesler D, Park YJ
Cell
PDB: 6VXX, 6VYB

External Resources

Resource Reference ID
GenBank: QHD43416
UniProt: P0DTC2
ViPR: link

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MFVFLVLLPL VSSQCVNLTT RTQLPPAYTN SFTRGVYYPD KVFRSSVLHS TQDLFLPFFS NVTWFHAIHV SGTNGTKRFD NPVLPFNDGV YFASTEKSNI IRGWIFGTTL DSKTQSLLIV NNATNVVIKV CEFQFCNDPF LGVYYHKNNK SWMESEFRVY SSANNCTFEY VSQPFLMDLE GKQGNFKNLR EFVFKNIDGY FKIYSKHTPI NLVRDLPQGF SALEPLVDLP IGINITRFQT LLALHRSYLT PGDSSSGWTA GAAAYYVGYL QPRTFLLKYN ENGTITDAVD CALDPLSETK CTLKSFTVEK GIYQTSNFRV QPTESIVRFP NITNLCPFGE VFNATRFASV YAWNRKRISN CVADYSVLYN SASFSTFKCY GVSPTKLNDL CFTNVYADSF VIRGDEVRQI APGQTGKIAD YNYKLPDDFT GCVIAWNSNN LDSKVGGNYN YLYRLFRKSN LKPFERDIST EIYQAGSTPC NGVEGFNCYF PLQSYGFQPT NGVGYQPYRV VVLSFELLHA PATVCGPKKS TNLVKNKCVN FNFNGLTGTG VLTESNKKFL PFQQFGRDIA DTTDAVRDPQ TLEILDITPC SFGGVSVITP GTNTSNQVAV LYQDVNCTEV PVAIHADQLT PTWRVYSTGS NVFQTRAGCL IGAEHVNNSY ECDIPIGAGI CASYQTQTNS PRRARSVASQ SIIAYTMSLG AENSVAYSNN SIAIPTNFTI SVTTEILPVS MTKTSVDCTM YICGDSTECS NLLLQYGSFC TQLNRALTGI AVEQDKNTQE VFAQVKQIYK TPPIKDFGGF NFSQILPDPS KPSKRSFIED LLFNKVTLAD AGFIKQYGDC LGDIAARDLI CAQKFNGLTV LPPLLTDEMI AQYTSALLAG TITSGWTFGA GAALQIPFAM QMAYRFNGIG VTQNVLYENQ KLIANQFNSA IGKIQDSLSS TASALGKLQD VVNQNAQALN TLVKQLSSNF GAISSVLNDI LSRLDKVEAE VQIDRLITGR LQSLQTYVTQ QLIRAAEIRA SANLAATKMS ECVLGQSKRV DFCGKGYHLM SFPQSAPHGV VFLHVTYVPA QEKNFTTAPA ICHDGKAHFP REGVFVSNGT HWFVTQRNFY EPQIITTDNT FVSGNCDVVI GIVNNTVYDP LQPELDSFKE ELDKYFKNHT SPDVDLGDIS GINASVVNIQ KEIDRLNEVA KNLNESLIDL QELGKYEQYI KWPWYIWLGF IAGLIAIVMV TIMLCCMTSC CSCLKGCCSC GSCCKFDEDD SEPVLKGVKL HYT

NT Sequence
ATGTTTGTTT TTCTTGTTTT ATTGCCACTA GTCTCTAGTC AGTGTGTTAA TCTTACAACC AGAACTCAAT TACCCCCTGC ATACACTAAT TCTTTCACAC GTGGTGTTTA TTACCCTGAC AAAGTTTTCA GATCCTCAGT TTTACATTCA ACTCAGGACT TGTTCTTACC TTTCTTTTCC AATGTTACTT GGTTCCATGC TATACATGTC TCTGGGACCA ATGGTACTAA GAGGTTTGAT AACCCTGTCC TACCATTTAA TGATGGTGTT TATTTTGCTT CCACTGAGAA GTCTAACATA ATAAGAGGCT GGATTTTTGG TACTACTTTA GATTCGAAGA CCCAGTCCCT ACTTATTGTT AATAACGCTA CTAATGTTGT TATTAAAGTC TGTGAATTTC AATTTTGTAA TGATCCATTT TTGGGTGTTT ATTACCACAA AAACAACAAA AGTTGGATGG AAAGTGAGTT CAGAGTTTAT TCTAGTGCGA ATAATTGCAC TTTTGAATAT GTCTCTCAGC CTTTTCTTAT GGACCTTGAA GGAAAACAGG GTAATTTCAA AAATCTTAGG GAATTTGTGT TTAAGAATAT TGATGGTTAT TTTAAAATAT ATTCTAAGCA CACGCCTATT AATTTAGTGC GTGATCTCCC TCAGGGTTTT TCGGCTTTAG AACCATTGGT AGATTTGCCA ATAGGTATTA ACATCACTAG GTTTCAAACT TTACTTGCTT TACATAGAAG TTATTTGACT CCTGGTGATT CTTCTTCAGG TTGGACAGCT GGTGCTGCAG CTTATTATGT GGGTTATCTT CAACCTAGGA CTTTTCTATT AAAATATAAT GAAAATGGAA CCATTACAGA TGCTGTAGAC TGTGCACTTG ACCCTCTCTC AGAAACAAAG TGTACGTTGA AATCCTTCAC TGTAGAAAAA GGAATCTATC AAACTTCTAA CTTTAGAGTC CAACCAACAG AATCTATTGT TAGATTTCCT AATATTACAA ACTTGTGCCC TTTTGGTGAA GTTTTTAACG CCACCAGATT TGCATCTGTT TATGCTTGGA ACAGGAAGAG AATCAGCAAC TGTGTTGCTG ATTATTCTGT CCTATATAAT TCCGCATCAT TTTCCACTTT TAAGTGTTAT GGAGTGTCTC CTACTAAATT AAATGATCTC TGCTTTACTA ATGTCTATGC AGATTCATTT GTAATTAGAG GTGATGAAGT CAGACAAATC GCTCCAGGGC AAACTGGAAA GATTGCTGAT TATAATTATA AATTACCAGA TGATTTTACA GGCTGCGTTA TAGCTTGGAA TTCTAACAAT CTTGATTCTA AGGTTGGTGG TAATTATAAT TACCTGTATA GATTGTTTAG GAAGTCTAAT CTCAAACCTT TTGAGAGAGA TATTTCAACT GAAATCTATC AGGCCGGTAG CACACCTTGT AATGGTGTTG AAGGTTTTAA TTGTTACTTT CCTTTACAAT CATATGGTTT CCAACCCACT AATGGTGTTG GTTACCAACC ATACAGAGTA GTAGTACTTT CTTTTGAACT TCTACATGCA CCAGCAACTG TTTGTGGACC TAAAAAGTCT ACTAATTTGG TTAAAAACAA ATGTGTCAAT TTCAACTTCA ATGGTTTAAC AGGCACAGGT GTTCTTACTG AGTCTAACAA AAAGTTTCTG CCTTTCCAAC AATTTGGCAG AGACATTGCT GACACTACTG ATGCTGTCCG TGATCCACAG ACACTTGAGA TTCTTGACAT TACACCATGT TCTTTTGGTG GTGTCAGTGT TATAACACCA GGAACAAATA CTTCTAACCA GGTTGCTGTT CTTTATCAGG ATGTTAACTG CACAGAAGTC CCTGTTGCTA TTCATGCAGA TCAACTTACT CCTACTTGGC GTGTTTATTC TACAGGTTCT AATGTTTTTC AAACACGTGC AGGCTGTTTA ATAGGGGCTG AACATGTCAA CAACTCATAT GAGTGTGACA TACCCATTGG TGCAGGTATA TGCGCTAGTT ATCAGACTCA GACTAATTCT CCTCGGCGGG CACGTAGTGT AGCTAGTCAA TCCATCATTG CCTACACTAT GTCACTTGGT GCAGAAAATT CAGTTGCTTA CTCTAATAAC TCTATTGCCA TACCCACAAA TTTTACTATT AGTGTTACCA CAGAAATTCT ACCAGTGTCT ATGACCAAGA CATCAGTAGA TTGTACAATG TACATTTGTG GTGATTCAAC TGAATGCAGC AATCTTTTGT TGCAATATGG CAGTTTTTGT ACACAATTAA ACCGTGCTTT AACTGGAATA GCTGTTGAAC AAGACAAAAA CACCCAAGAA GTTTTTGCAC AAGTCAAACA AATTTACAAA ACACCACCAA TTAAAGATTT TGGTGGTTTT AATTTTTCAC AAATATTACC AGATCCATCA AAACCAAGCA AGAGGTCATT TATTGAAGAT CTACTTTTCA ACAAAGTGAC ACTTGCAGAT GCTGGCTTCA TCAAACAATA TGGTGATTGC CTTGGTGATA TTGCTGCTAG AGACCTCATT TGTGCACAAA AGTTTAACGG CCTTACTGTT TTGCCACCTT TGCTCACAGA TGAAATGATT GCTCAATACA CTTCTGCACT GTTAGCGGGT ACAATCACTT CTGGTTGGAC CTTTGGTGCA GGTGCTGCAT TACAAATACC ATTTGCTATG CAAATGGCTT ATAGGTTTAA TGGTATTGGA GTTACACAGA ATGTTCTCTA TGAGAACCAA AAATTGATTG CCAACCAATT TAATAGTGCT ATTGGCAAAA TTCAAGACTC ACTTTCTTCC ACAGCAAGTG CACTTGGAAA ACTTCAAGAT GTGGTCAACC AAAATGCACA AGCTTTAAAC ACGCTTGTTA AACAACTTAG CTCCAATTTT GGTGCAATTT CAAGTGTTTT AAATGATATC CTTTCACGTC TTGACAAAGT TGAGGCTGAA GTGCAAATTG ATAGGTTGAT CACAGGCAGA CTTCAAAGTT TGCAGACATA TGTGACTCAA CAATTAATTA GAGCTGCAGA AATCAGAGCT TCTGCTAATC TTGCTGCTAC TAAAATGTCA GAGTGTGTAC TTGGACAATC AAAAAGAGTT GATTTTTGTG GAAAGGGCTA TCATCTTATG TCCTTCCCTC AGTCAGCACC TCATGGTGTA GTCTTCTTGC ATGTGACTTA TGTCCCTGCA CAAGAAAAGA ACTTCACAAC TGCTCCTGCC ATTTGTCATG ATGGAAAAGC ACACTTTCCT CGTGAAGGTG TCTTTGTTTC AAATGGCACA CACTGGTTTG TAACACAAAG GAATTTTTAT GAACCACAAA TCATTACTAC AGACAACACA TTTGTGTCTG GTAACTGTGA TGTTGTAATA GGAATTGTCA ACAACACAGT TTATGATCCT TTGCAACCTG AATTAGACTC ATTCAAGGAG GAGTTAGATA AATATTTTAA GAATCATACA TCACCAGATG TTGATTTAGG TGACATCTCT GGCATTAATG CTTCAGTTGT AAACATTCAA AAAGAAATTG ACCGCCTCAA TGAGGTTGCC AAGAATTTAA ATGAATCTCT CATCGATCTC CAAGAACTTG GAAAGTATGA GCAGTATATA AAATGGCCAT GGTACATTTG GCTAGGTTTT ATAGCTGGCT TGATTGCCAT AGTAATGGTG ACAATTATGC TTTGCTGTAT GACCAGTTGC TGTAGTTGTC TCAAGGGCTG TTGTTCTTGT GGATCCTGCT GCAAATTTGA TGAAGACGAC TCTGAGCCAG TGCTCAAAGG AGTCAAATTA CATTACACA

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