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Seattle Structural Genomics Center for Infectious Disease

BrabA.00010.a: Short-chain dehydrogenase/reductase SDR:Glucose/ribitol dehydrogenase

Target Characteristics

from organism: Brucella melitensis biovar Abortus 2308
most recent status: in PDB
center reference id: BrabA.00010.a
is community request: False
associated disease: Brucellosis
NIH risk group: 3
is select agent: True
NIH priority
pathogens category:
IIIB

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
BrabA.00010.a.A1.GE25363 Full length( BrabA.00010.a ) 1 272 GE25363
BrabA.00010.a.B1.GE25459 Full length( BrabA.00010.a ) 1 272 GE25459
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
BrabA.00010.a.A1.PS00048 Full length( BrabA.00010.a ) 1 272

Structures

image of structure for 3GRK
3GRK
Deposited: 3/25/2009
Determination: XRay
Diffraction Image
Clone: BrabA.00010.a.A1.GE25363
Protein: BrabA.00010.a.A1.PS00048

Citations by Others

Crystal structures and kinetic properties of enoyl-acyl carrier protein reductase I from Candidatus Liberibacter asiaticus
L Jiang, Z Gao, Y Li, S Wang, Y Dong - Protein Science, 2014 - Wiley Online Library
PDB: 3GRK
< i> Staphylococcus aureus FabI: Inhibition, Substrate Recognition, and Potential Implications for In Vivo Essentiality
J Schiebel, A Chang, H Lu, MV Baxter, PJ Tonge? - Structure, 2012 - Elsevier
cited by: 33 others
PDB: 3GRK

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_130466
PATRIC ID: fig|359391.4.peg.468
RefSeq: YP_413907
UniProt: Q2YMC8

Enzyme & Pathway Information

Pathway Pathway ID EC Number
biotin biosynthesis I BIOTIN-BIOSYNTHESIS-PWY 1.3.1.9
fatty acid elongation -- saturated FASYN-ELONG-PWY 1.3.1.9
(5Z)-dodecenoate biosynthesis I PWY0-862 1.3.1.9
superpathway of fatty acid biosynthesis I (E. coli) PWY0-881 1.3.1.9
superpathway of fatty acid biosynthesis II (plant) PWY-5156 1.3.1.9
palmitate biosynthesis II (bacteria and plants) PWY-5971 1.3.1.9
cis-vaccenate biosynthesis PWY-5973 1.3.1.9
stearate biosynthesis II (bacteria and plants) PWY-5989 1.3.1.9
superpathway of mycolate biosynthesis PWY-6113 1.3.1.9
palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) PWY-6282 1.3.1.9
superpathway of unsaturated fatty acids biosynthesis (E. coli) PWY-6284 1.3.1.9
superpathway of fatty acids biosynthesis (E. coli) PWY-6285 1.3.1.9
8-amino-7-oxononanoate biosynthesis I PWY-6519 1.3.1.9
triclosan resistance PWY-7096 1.3.1.9
gondoate biosynthesis (anaerobic) PWY-7663 1.3.1.9
oleate biosynthesis IV (anaerobic) PWY-7664 1.3.1.9
(5Z)-dodecenoate biosynthesis II PWY-7858 1.3.1.9
mycolate biosynthesis PWYG-321 1.3.1.9

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MTAQSGLLQG KRGLILGVAN NRSIAWGIAK AAREAGAELA FTYQGDALKK RVEPLAEELG AFVAGHCDVA DAASIDAVFE TLEKKWGKLD FLVHAIGFSD KDELTGRYID TSEANFTNTM LISVYSLTAV SRRAEKLMAD GGSILTLTYY GAEKVMPNYN VMGVAKAALE ASVKYLAVDL GPQNIRVNAI SAGPIKTLAA SGIGDFRYIL KWNEYNAPLR RTVTIDEVGD VGLYFLSDLS RSVTGEVHHA DSGYHVIGMK AVDAPDISVV KD

NT Sequence
ATGACCGCAC AGTCTGGTTT GTTGCAGGGC AAGCGTGGAT TGATTCTAGG CGTGGCCAAT AATCGCTCTA TCGCTTGGGG CATTGCAAAA GCCGCCCGTG AAGCTGGCGC AGAGCTTGCA TTCACCTATC AGGGTGACGC ATTGAAGAAG CGTGTGGAGC CGCTGGCCGA GGAGCTTGGC GCCTTCGTCG CCGGACATTG CGACGTCGCC GATGCGGCGA GCATCGATGC GGTTTTTGAA ACGCTTGAGA AGAAGTGGGG CAAGCTCGAC TTCCTGGTGC ACGCAATCGG TTTCTCCGAC AAGGACGAGC TGACCGGCCG CTATATCGAT ACGTCGGAAG CCAATTTCAC CAATACGATG CTGATTTCGG TCTATTCGCT GACGGCGGTT TCGCGCCGCG CGGAAAAGCT GATGGCCGAT GGCGGATCGA TTCTGACGCT GACCTATTAC GGCGCTGAAA AGGTCATGCC GAATTACAAT GTCATGGGCG TGGCCAAGGC AGCCCTTGAG GCGAGCGTGA AATATCTGGC CGTCGATCTT GGCCCCCAGA ACATTCGCGT CAATGCAATC TCGGCTGGCC CCATCAAGAC GCTTGCCGCT TCCGGCATTG GTGACTTCCG CTATATCCTG AAGTGGAACG AATATAATGC GCCGCTGCGC CGCACCGTCA CGATCGACGA GGTGGGTGAT GTCGGCCTTT ATTTCCTTTC GGACCTGTCG CGTTCGGTTA CAGGCGAAGT GCACCATGCC GACAGCGGCT ATCATGTCAT TGGCATGAAA GCGGTTGACG CACCGGATAT CTCGGTCGTG AAAGAC

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