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Seattle Structural Genomics Center for Infectious Disease

BrabA.00014.a: Isocitrate lyase and phosphorylmutase:Isocitrate lyase

Target Characteristics

from organism: Brucella melitensis biovar Abortus 2308
most recent status: in PDB
center reference id: BrabA.00014.a
is community request: False
associated disease: Brucellosis
NIH risk group: 3
is select agent: True
NIH priority
pathogens category:
IIIB

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
BrabA.00014.a.A1.GE25213 Full length( BrabA.00014.a ) 1 429 GE25213
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Structures

image of structure for 3E5B
3E5B
Deposited: 8/13/2008
Determination: XRay
Diffraction Image
Clone: BrabA.00014.a.A1.GE25213
Protein: BrabA.00014.a.A1.PW25251
image of structure for 3EOL
3EOL
Deposited: 9/28/2008
Determination: XRay
Diffraction Image
Clone: BrabA.00014.a.A1.GE25213
Protein: BrabA.00014.a.A1.PW25251
image of structure for 3OQ8
3OQ8
Deposited: 9/2/2010
Determination: XRay
Diffraction Image
Clone: BrabA.00014.a.A1.GE25213
Protein: BrabA.00014.a.A1.PW25251
image of structure for 3P0X
3P0X
Deposited: 9/29/2010
Determination: XRay
Diffraction Image
Clone: BrabA.00014.a.A1.GE25213
Protein: BrabA.00014.a.A1.PW25251

Citations by Others

Potential Inhibitors for Isocitrate Lyase of Mycobacterium tuberculosis and Non-M. tuberculosis: A Summary
YV Lee, HA Wahab, YS Choong - BioMed Research International, 2015 - hindawi.com
cited by: 2 others
PDB: 3E5B, 3EOL, 3OQ8, 3P0X
Structure of the Vibrio cholerae fatty acid regulator FadR
W Shi - 2015 - search.proquest.com
PDB: 3E5B, 3P0X
Crystal structure and functional analysis of isocitrate lyases from Magnaporthe oryzae and Fusarium graminearum
Y Park, Y Cho, YH Lee, YW Lee, S Rhee - Journal of structural biology, 2016 - Elsevier
PDB: 3OQ8
PEPTIDOMIMETIC COMPOUNDS
RT Skerlj, AC Good - US Patent 20,150,353,606, 2015 - freepatentsonline.com
PDB: 3OQ8
Lifting the lid on GPCRs: the role of extracellular loops
M Wheatley, D Wootten, MT Conner… - British journal of …, 2012 - Wiley Online Library
cited by: 86 others
PDB: 3P0X

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_129572
PATRIC ID: fig|359391.4.peg.1690
RefSeq: YP_414989
UniProt: Q2YQA0

Enzyme & Pathway Information

Pathway Pathway ID EC Number
superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass GLYCOLYSIS-TCA-GLYOX-BYPASS 4.1.3.1
glyoxylate cycle GLYOXYLATE-BYPASS 4.1.3.1
TCA cycle IV (2-oxoglutarate decarboxylase) P105-PWY 4.1.3.1
superpathway of glyoxylate cycle and fatty acid degradation PWY-561 4.1.3.1
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase) PWY-6969 4.1.3.1
superpathway of glyoxylate bypass and TCA TCA-GLYOX-BYPASS 4.1.3.1

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MTDFYSLIPS APKGRFDGIE RAHTAEDVKR LRGSVEIKYS LAEMGANRLW KLIHEEDFVN ALGALSGNQA MQMVRAGLKA IYLSGWQVAA DANTASAMYP DQSLYPANAG PELAKRINRT LQRADQIETA EGKGLSVDTW FAPIVADAEA GFGGPLDAFE IMKAYIEAGA AGVHFEDQLA SEKKCGHLGG KVLIPTAAHI RNLNAARLAA DVMGTPTLIV ARTDAEAAKL LTSDIDERDQ PFVDYEAGRT AEGFYQVKNG IEPCIARAIA YAPYCDLIWM ETSKPDLAQA RRFAEAVHKA HPGKLLAYNC SPSFNWKKNL DDATIAKFQR ELGAMGYKFQ FITLAGFHQL NYGMFELARG YKDRQMAAYS ELQQAEFAAE ADGYTATKHQ REVGTGYFDA VSLAITGGQS STTAMKESTE TAQFKPAAE

NT Sequence
ATGACAGATT TTTACAGCCT CATCCCTTCG GCACCCAAGG GCCGCTTCGA CGGCATTGAA CGTGCGCATA CGGCCGAAGA CGTGAAAAGG CTGCGCGGTT CGGTGGAGAT AAAGTATTCG CTGGCCGAAA TGGGTGCAAA CCGCCTCTGG AAGCTGATCC ACGAGGAAGA TTTCGTCAAT GCGCTGGGCG CGCTTTCCGG CAACCAGGCC ATGCAGATGG TTCGCGCCGG GTTGAAGGCG ATCTACCTTT CCGGCTGGCA GGTTGCAGCA GACGCCAACA CGGCATCAGC CATGTATCCC GACCAGTCGC TCTATCCGGC CAATGCCGGG CCAGAGCTTG CAAAGCGCAT CAACCGCACG CTGCAACGCG CCGACCAGAT CGAAACCGCC GAAGGCAAGG GGCTTTCGGT TGACACATGG TTCGCGCCCA TCGTGGCGGA TGCCGAGGCA GGCTTTGGCG GCCCGCTGGA TGCCTTCGAG ATCATGAAAG CCTATATCGA GGCCGGTGCT GCGGGCGTTC ACTTTGAAGA CCAGCTTGCT TCGGAAAAGA AGTGCGGCCA TCTGGGCGGC AAGGTTCTGA TCCCGACCGC AGCGCACATC CGCAACCTCA ACGCGGCACG CCTTGCAGCC GACGTCATGG GCACGCCGAC CCTCATCGTG GCGCGCACGG ATGCGGAAGC AGCCAAGCTT CTGACGTCGG ATATCGACGA GCGCGACCAG CCTTTCGTCG ATTACGAAGC AGGCCGCACG GCGGAAGGCT TCTATCAGGT GAAGAATGGC ATCGAGCCAT GCATCGCCCG TGCGATTGCC TATGCGCCTT ATTGCGATCT GATCTGGATG GAAACGTCCA AGCCTGATCT CGCACAGGCC CGTCGCTTCG CGGAAGCCGT GCACAAGGCG CATCCGGGCA AGCTGCTCGC CTATAACTGC TCGCCGTCGT TCAACTGGAA AAAGAACCTC GACGACGCGA CGATTGCCAA GTTCCAGCGC GAGCTGGGCG CGATGGGCTA CAAGTTCCAG TTCATCACGC TGGCTGGCTT CCACCAGCTC AACTACGGCA TGTTCGAGCT GGCACGCGGC TACAAGGATC GTCAGATGGC GGCTTATTCC GAGCTGCAAC AGGCGGAATT TGCAGCCGAA GCCGATGGCT ACACGGCAAC CAAGCACCAG CGCGAAGTCG GCACCGGCTA TTTCGATGCC GTGTCGCTCG CAATCACCGG CGGCCAGTCT TCGACCACCG CCATGAAGGA ATCGACCGAA ACCGCACAGT TCAAGCCGGC TGCCGAG

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