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Seattle Structural Genomics Center for Infectious Disease

BrabA.17240.a: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (IspG/GcpE) (IspG/H)

Target Characteristics

from organism: Brucella melitensis biovar Abortus 2308
most recent status: selected
center reference id: BrabA.17240.a
is community request: False
associated disease: Brucellosis
NIH risk group: 3
is select agent: True
NIH priority
pathogens category:
IIIB

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

External Resources

Resource Reference ID
OrthoMCL: OG5_130276
PATRIC ID: fig|359391.4.peg.1853
RefSeq: YP_415135.1
UniProt: Q2YLG4

Enzyme & Pathway Information

Pathway Pathway ID EC Number
methylerythritol phosphate pathway II PWY-7560 1.17.7.1
methylerythritol phosphate pathway I NONMEVIPP-PWY 1.17.7.3
superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) PWY-5121 1.17.7.3
isoprene biosynthesis I PWY-6270 1.17.7.3
superpathway of ergosterol biosynthesis II PWY-7156 1.17.7.3
taxadiene biosynthesis (engineered) PWY-7392 1.17.7.3

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MSSETVSYFS HPFPRRQSVG VSVGGVIVGG SAPVVVQSMT NTDTADVDST VAQVAALHRA GSEIVRITVD RDESAAAVPK IRERLERLGH DVPLVGDFHY IGHKLLADHP ACAEALSKYR INPGNVGFKD KKDKQFADIV EMAIRYDKPV RIGVNWGSLD QELLTALMDR NQAEGAPLSA QDVMREAIVQ SALISANLAE EIGLGRDKII LSAKVSQVQD LIAVYTMLAQ RSNHALHLGL TEAGMGTKGI VASSAAMGIL LQQGIGDTIR ISLTPEPGGD RTREVQVAQE LLQTMGFRQF VPIVAACPGC GRTTSTVFQE LAQTIQEDIR RNMPLWREKY PGVEALSVAV MGCIVNGPGE SKHADIGISL PGTGETPSAP VFVDGKKVTT LRGPGIAEDF QKMVADYIEN RFGLGRKIAS

NT Sequence
ATGTCGTCCG AGACCGTCAG CTATTTTTCG CATCCATTTC CCCGCCGCCA GTCGGTTGGC GTCAGTGTCG GTGGCGTTAT CGTCGGCGGC AGTGCGCCGG TGGTGGTCCA GTCCATGACC AACACCGACA CGGCCGATGT GGATTCCACG GTTGCACAGG TGGCCGCGCT TCATCGTGCC GGTTCGGAAA TCGTGCGCAT CACGGTGGAT CGTGATGAAT CGGCGGCTGC CGTGCCGAAA ATCCGCGAGC GGCTGGAGCG TCTTGGCCAT GATGTGCCGC TGGTGGGCGA TTTCCATTAT ATCGGTCACA AGCTGCTTGC CGATCATCCG GCCTGTGCGG AGGCTCTTTC CAAATACCGC ATCAATCCCG GCAATGTCGG CTTCAAGGAC AAGAAGGACA AGCAGTTCGC CGATATTGTC GAAATGGCGA TCCGCTACGA CAAGCCCGTG CGCATCGGCG TCAACTGGGG ATCGCTCGAT CAGGAGCTTT TGACCGCGCT GATGGACCGC AATCAGGCCG AGGGTGCGCC GCTTTCCGCG CAGGATGTCA TGCGTGAAGC CATTGTGCAG TCTGCGCTGA TTTCGGCCAA TCTTGCCGAG GAAATCGGGC TTGGCCGCGA CAAGATCATC CTGTCGGCCA AGGTCAGCCA GGTGCAGGAT CTGATTGCCG TCTATACGAT GCTGGCGCAG CGTTCCAATC ATGCGCTGCA TCTGGGACTT ACCGAAGCGG GGATGGGCAC GAAGGGCATC GTCGCGTCGT CGGCTGCCAT GGGCATTTTG TTGCAGCAGG GCATTGGCGA TACGATCCGC ATTTCCCTGA CGCCGGAACC GGGCGGCGAC CGCACGCGTG AAGTGCAGGT GGCGCAGGAA TTGCTGCAAA CCATGGGGTT CCGCCAGTTT GTTCCGATTG TCGCCGCCTG TCCGGGCTGC GGCCGCACGA CGTCCACGGT GTTTCAGGAA CTGGCGCAGA CCATTCAGGA AGATATCCGC CGCAATATGC CGCTCTGGCG CGAGAAATAT CCGGGTGTCG AGGCGCTTTC GGTTGCTGTC ATGGGCTGTA TCGTCAATGG GCCGGGCGAA TCGAAACATG CCGATATCGG CATTTCGCTT CCGGGCACCG GCGAAACCCC GTCCGCCCCG GTTTTTGTGG ATGGCAAGAA GGTCACGACC CTGCGTGGTC CGGGGATTGC CGAGGACTTC CAGAAGATGG TTGCCGACTA TATCGAAAAC CGCTTTGGGC TTGGTCGTAA GATCGCGTCG

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