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Seattle Structural Genomics Center for Infectious Disease

BrmiA.00168.a: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) / 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12)

Target Characteristics

from organism: Brucella microti CCM 4915
most recent status: target approved
center reference id: BrmiA.00168.a
is community request: False
associated disease:
NIH risk group: 3
is select agent: False
NIH priority
pathogens category:
IIIB

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

External Resources

Resource Reference ID
PATRIC ID: fig|568815.3.peg.2343
RefSeq: WP_015799637.1
RefSeq: YP_003107057.1
UniProt: C7LC73

Enzyme & Pathway Information

Pathway Pathway ID EC Number
methylerythritol phosphate pathway I NONMEVIPP-PWY 2.7.7.60
superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) PWY-5121 2.7.7.60
isoprene biosynthesis I PWY-6270 2.7.7.60
superpathway of ergosterol biosynthesis II PWY-7156 2.7.7.60
taxadiene biosynthesis (engineered) PWY-7392 2.7.7.60
methylerythritol phosphate pathway II PWY-7560 2.7.7.60
methylerythritol phosphate pathway I NONMEVIPP-PWY 4.6.1.12
superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) PWY-5121 4.6.1.12
isoprene biosynthesis I PWY-6270 4.6.1.12
superpathway of ergosterol biosynthesis II PWY-7156 4.6.1.12
taxadiene biosynthesis (engineered) PWY-7392 4.6.1.12
methylerythritol phosphate pathway II PWY-7560 4.6.1.12

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MKSAYSLITP LSERKEKQPE RTINQLPSGI CRRKALFGLQ AQSLAEVTVI SKAAAVIVAA GRGERAGQSA EGPKQYRLIG AEAVLARTLR AFTDCPLIGT IAVVIHPDDH ALYRRAVPEK HENVILVTGG PTRQESTRLG LLALKDEAPQ YVLIHDGVRP FIGQDLLERI IANLTPDNGV LPALAVSDTL KRAAADGMVE TTISRTGLFA AQTPQAFPYA PILDAHEKAF AINRTDFTDD AAIAEWQEIA VRIIEGSADN TKLTWAKDIE MADKRLRQDH AVFPDIRTGN GYDVHSFEPG DHVTLCGVKI PHEAKLNGHS DADVALHALT DALLATRGTG DIGTHFPPSD PQWKGAASRI FIEHAAKIVR EAGGRIANVD VTLISEAPKI GPHRAAMTQA LCDMLGIAAD RVSIKATTNE KLGFVGRREG IAAIATATVI YPGEVPE

NT Sequence
ATGAAATCCG CATACAGTTT AATCACCCCG CTTTCCGAAC GCAAGGAAAA GCAGCCTGAA CGCACGATAA ATCAATTGCC GTCTGGCATT TGTCGTCGCA AGGCCTTATT CGGCTTGCAG GCACAATCTT TGGCAGAGGT TACAGTCATT TCAAAGGCAG CAGCAGTCAT CGTGGCGGCC GGTCGCGGCG AGCGGGCGGG GCAAAGCGCC GAGGGGCCGA AGCAATATCG GCTCATTGGC GCAGAGGCCG TGCTTGCCCG CACTTTGCGC GCTTTTACCG ATTGCCCGCT CATCGGCACA ATCGCCGTCG TCATCCATCC CGACGATCAT GCGCTTTATC GGCGCGCTGT GCCGGAGAAG CATGAGAACG TCATCCTCGT TACCGGTGGC CCCACCCGAC AGGAATCGAC CCGCCTCGGT CTTCTGGCCT TGAAGGACGA AGCGCCGCAA TATGTGTTGA TCCATGATGG CGTGCGTCCT TTCATCGGTC AGGATTTGCT GGAACGCATC ATTGCAAACC TCACCCCTGA TAATGGTGTG CTTCCCGCCC TCGCCGTCTC CGACACGTTG AAACGGGCGG CGGCAGACGG CATGGTAGAG ACCACCATTT CCCGTACCGG CTTGTTCGCG GCGCAGACGC CGCAAGCTTT TCCCTATGCG CCGATCTTGG ACGCACATGA GAAAGCCTTC GCAATCAACC GCACCGACTT TACCGACGAT GCCGCCATTG CCGAATGGCA GGAAATTGCT GTTCGCATTA TCGAAGGTTC GGCGGATAAT ACAAAGCTCA CCTGGGCAAA GGATATTGAA ATGGCAGACA AGCGCCTGCG GCAGGACCAT GCCGTATTTC CCGACATTCG CACGGGCAAT GGCTATGATG TTCATTCTTT CGAGCCGGGT GATCATGTCA CGCTTTGCGG CGTGAAAATC CCCCATGAGG CAAAGCTCAA CGGTCACTCC GATGCCGATG TGGCCCTTCA TGCGCTGACC GACGCCCTGC TCGCCACGCG CGGTACGGGT GATATTGGCA CACATTTTCC GCCATCCGAT CCGCAATGGA AAGGAGCTGC CTCACGCATC TTCATCGAAC ATGCGGCCAA AATCGTCCGC GAGGCGGGAG GCCGGATCGC CAATGTGGAC GTGACACTCA TCAGTGAAGC GCCGAAGATC GGCCCCCATC GCGCCGCCAT GACACAAGCA CTCTGCGACA TGCTGGGCAT CGCCGCCGAC CGGGTTTCCA TCAAGGCTAC GACGAACGAA AAGCTTGGCT TTGTCGGCCG TCGCGAAGGC ATTGCAGCCA TCGCAACCGC AACCGTCATC TACCCCGGAG AAGTACCGGA A

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