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Seattle Structural Genomics Center for Infectious Disease

BupsA.00008.a: serine hydroxymethyltransferase

Target Characteristics

from organism: Burkholderia pseudomallei 1710b
most recent status: in PDB
center reference id: BupsA.00008.a
is community request: False
associated disease: Melioidosis
NIH risk group: 3
is select agent: True
NIH priority
pathogens category:
IIIB

Ordering Clones & Proteins

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Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
BupsA.00008.a.D19.PD00019 Full length( BupsA.00008.a ) 1 424

Structures

image of structure for 3ECD
3ECD
Deposited: 8/29/2008
Determination: XRay
Diffraction Image
Clone: BupsA.00008.a.D19.GE00001
Protein: BupsA.00008.a.D19.PD00019

Citations by Others

How pyridoxal 5'‐phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state
G Giardina, P Brunotti, A Fiascarelli, A Cicalini… - FEBS …, 2015 - Wiley Online Library
PDB: 3ECD
Rare Sidechain Conformations in Proteins and DNA
BJ Hintze - 2015 - search.proquest.com
PDB: 3ECD
Structural adaptation of serine hydroxymethyltransferase to low temperatures
A Siglioccolo, F Bossa, S Pascarella - International journal of biological Macromolecules, 2010 - Elsevier
cited by: 13 others
PDB: 3ECD
Model the Solvent-Excluded Surface of 3D Protein Molecular Structures Using Geometric PDE-Based Level-Set Method
Q Pan, XC Tai - Communications in Computational Physics, 2009 - uib.no
cited by: 1 other
PDB: 3ECD
Single-stranded oligonucleotides can inhibit cytokine production induced by human toll-like receptor 3
CT Ranjith-Kumar, KE Duffy, JL Jordan? - Molecular and cellular biology, 2008 - Am Soc Microbiol
cited by: 25 others
PDB: 3ECD

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_126679
PATRIC ID: fig|320372.6.peg.6270
RefSeq: YP_337258
UniProt: Q3JGP5

Enzyme & Pathway Information

Pathway Pathway ID EC Number
N10-formyl-tetrahydrofolate biosynthesis 1CMET2-PWY 2.1.2.1
glycine biosynthesis I GLYSYN-PWY 2.1.2.1
formaldehyde assimilation I (serine pathway) PWY-1622 2.1.2.1
photorespiration PWY-181 2.1.2.1
folate polyglutamylation PWY-2161 2.1.2.1
folate transformations I PWY-2201 2.1.2.1
glycine betaine degradation I PWY-3661 2.1.2.1
glycine betaine degradation II (mammalian) PWY-3661-1 2.1.2.1
folate transformations II PWY-3841 2.1.2.1
purine nucleobases degradation II (anaerobic) PWY-5497 2.1.2.1
superpathway of L-serine and glycine biosynthesis I SER-GLYSYN-PWY 2.1.2.1

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MSNANPFFSQ SLAERDASVR GAILKELERQ QSQVELIASE NIVSRAVLDA QGSVLTNKYA EGYPGKRYYG GCEFADEVEA LAIERVKRLF NAGHANVQPH SGAQANGAVM LALAKPGDTV LGMSLDAGGH LTHGAKPALS GKWFNALQYG VSRDTMLIDY DQVEALAQQH KPSLIIAGFS AYPRKLDFAR FRAIADSVGA KLMVDMAHIA GVIAAGRHAN PVEHAHVVTS TTHKTLRGPR GGFVLTNDEE IAKKINSAVF PGLQGGPLMH VIAGKAVAFG EALTDDFKTY IDRVLANAQA LGDVLKAGGV DLVTGGTDNH LLLVDLRPKG LKGAQVEQAL ERAGITCNKN GIPFDPEKPT ITSGIRLGTP AGTTRGFGAA EFREVGRLIL EVFEALRTNP EGDHATEQRV RREIFALCER FPIY

NT Sequence
ATGTCGAACG CCAATCCCTT CTTCTCGCAA TCGCTCGCCG AGCGCGACGC GTCCGTGCGC GGCGCGATCC TCAAGGAACT CGAACGCCAG CAGTCGCAAG TCGAGCTGAT CGCGTCGGAG AACATCGTGT CGCGCGCGGT GCTCGATGCG CAGGGCTCGG TGCTGACCAA CAAGTATGCG GAAGGCTATC CGGGCAAGCG CTATTACGGC GGTTGCGAAT TCGCCGACGA AGTCGAGGCG CTCGCGATCG AGCGCGTGAA GCGGCTCTTC AACGCCGGCC ATGCGAACGT GCAGCCGCAC TCGGGCGCCC AGGCGAACGG CGCGGTGATG CTCGCGCTCG CGAAGCCGGG CGACACGGTG CTCGGAATGT CGCTCGACGC GGGCGGACAC CTCACGCACG GCGCGAAGCC GGCGCTGTCC GGCAAGTGGT TCAACGCGCT CCAGTACGGC GTGAGCCGCG ACACGATGCT GATCGATTAC GACCAGGTCG AGGCGCTCGC GCAGCAGCAC AAGCCGAGCC TCATCATCGC CGGCTTCTCC GCCTATCCGC GCAAGCTCGA CTTCGCGCGG TTTCGCGCGA TCGCCGATTC GGTCGGCGCG AAGCTGATGG TCGACATGGC GCATATCGCC GGCGTGATCG CCGCGGGCCG CCATGCGAAC CCGGTCGAAC ACGCGCACGT CGTCACGTCG ACGACGCACA AGACGCTGCG CGGCCCGCGC GGCGGCTTCG TGCTGACCAA CGACGAGGAG ATCGCGAAGA AGATCAACTC GGCGGTGTTC CCCGGCCTGC AGGGCGGCCC GCTGATGCAC GTGATCGCCG GCAAGGCGGT GGCGTTCGGC GAGGCGCTGA CAGACGATTT CAAGACCTAC ATCGATCGCG TGCTCGCGAA CGCGCAGGCG CTCGGCGACG TGCTGAAGGC GGGCGGCGTC GATCTCGTGA CGGGCGGCAC CGACAACCAT CTGCTGCTCG TCGATCTGCG CCCGAAGGGC CTGAAGGGCG CGCAGGTCGA GCAGGCGCTC GAGCGCGCGG GCATCACGTG CAACAAGAAC GGCATTCCGT TCGATCCGGA GAAGCCGACG ATCACGTCGG GCATCCGCCT CGGCACGCCG GCGGGCACGA CGCGCGGCTT CGGCGCAGCG GAGTTCCGCG AGGTCGGCCG GCTGATTCTC GAGGTGTTCG AGGCCCTGCG CACGAACCCG GAAGGCGATC ACGCGACCGA ACAGCGCGTG CGGCGCGAGA TCTTCGCGCT TTGCGAACGC TTCCCGATCT AC

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