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Seattle Structural Genomics Center for Infectious Disease

BupsA.00023.a: inorganic pyrophosphatase

Target Characteristics

from organism: Burkholderia pseudomallei 1710b
most recent status: in PDB
center reference id: BupsA.00023.a
is community request: True
associated disease: Melioidosis
NIH risk group: 3
is select agent: True
NIH priority
pathogens category:
IIIB

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
BupsA.00023.a.A1.GE24998 Full length( BupsA.00023.a ) 1 175 GE24998
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Structures

image of structure for 3D63
3D63
Deposited: 5/18/2008
Determination: XRay
Diffraction Image
Clone: BupsA.00023.a.A1.GE24998
Protein: BupsA.00023.a.A1.PW25498
image of structure for 3EIY
3EIY
Deposited: 9/17/2008
Determination: XRay
Diffraction Image
Clone: BupsA.00023.a.A1.GE24998
Protein: BupsA.00023.a.A1.PW25498
image of structure for 3EIZ
3EIZ
Deposited: 9/17/2008
Determination: XRay
Diffraction Image
Clone: BupsA.00023.a.A1.GE24998
Protein: BupsA.00023.a.A1.PW25498
image of structure for 3EJ0
3EJ0
Deposited: 9/17/2008
Determination: XRay
Diffraction Image
Clone: BupsA.00023.a.A1.GE24998
Protein: BupsA.00023.a.A1.PW25498
image of structure for 3EJ2
3EJ2
Deposited: 9/17/2008
Determination: XRay
Diffraction Image
Clone: BupsA.00023.a.A1.GE24998
Protein: BupsA.00023.a.A1.PW25498
image of structure for 3GVF
3GVF
Deposited: 3/30/2009
Determination: XRay
Diffraction Image
Clone: BupsA.00023.a.A1.GE24998
Protein: BupsA.00023.a.A1.PW25498

Publications by SSGCID

The role of medical structural genomics in discovering new drugs for infectious diseases.
Hol WG, Myler PJ, Stewart LJ, Van Voorhis WC
PLoS Comput. Biol. - 2009
volume 5, issue 10, pages e1000530
PMID: 19855826; PMCID: PMC2756625
PDB: 3EIY, 3EJ0
Combining functional and structural genomics to sample the essential Burkholderia structome.
Abendroth J, Armour B, Barrett L, Baugh L, Begley DW, Buchko GW, Choi R, Clifton MC, Dieterich SH, Dranow DM, Edwards TE, Fairman JW, Fox D, Gallagher LA, Gardberg AS, Gillespie A, Manoil C, Myler PJ, Nakazawa-Hewitt S, Napuli A, Nguyen MT, Patrapuvich R, Phan I, Stacy R, Staker BL, Stewart LJ, Van Voorhis WC
PLoS ONE - 2012
volume 8, issue 1, pages e53851
PMID: 23382856; PMCID: PMC3561365

Citations by Others

Asn112 in< i> Plasmodium falciparum glutathione S-transferase is essential for induced reversible tetramerization by phosphate or pyrophosphate
I Quesada-Soriano, C Barn, R Tllez-Sanz - et Biophysica Acta (BBA , 2014 - Elsevier
cited by: 1 other
PDB: 3EIY
Rare Sidechain Conformations in Proteins and DNA
BJ Hintze - 2015 - search.proquest.com
PDB: 3EIZ
Influence of azide incorporation on binding affinity by small papain inhibitors
AEM Wammes, TG Hendriks - Bioorganic & medicinal , 2014 - Elsevier
cited by: 1 other
PDB: 3EIZ
High pKa variability of cysteine residues in structural databases and the effect of H-bond contributions
SM Marino, İ Soylu - Türk Biyokimya Dergisi [Turkish Journal of …, 2014 - turkjbiochem.com
PDB: 3EIZ
Predicting protein-ligand binding site with differential evolution and support vector machine
GY Wong, FHF Leung, SH Ling - 2012 International Joint Conference on Neural Networks (IJCNN), 2012 - ieeexplore.ieee.org
PDB: 3EJ0
In silico modeling of cooperative ligand binding
M Vass - theop11.chem.elte.hu
PDB: 3EJ0
Synthesis and Activity of 1, 2, 3-Triazolyl-chalcones Against the Fungus Colletotrichum lindemuthianum
JC Pessoa, RF Azevedo, SF Mota- Letters in Organic, 2018 - ingentaconnect.com
PDB: 3EJ2
From Tilings to FibersBio-mathematical Aspects of Fold Plasticity
C Lesieur, L Vuillon - 2014 - cdn.intechopen.com
cited by: 1 other
PDB: 3GVF

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_128875
PATRIC ID: fig|320372.6.peg.1247
RefSeq: YP_332648
UniProt: Q3JUV5

Enzyme & Pathway Information

Pathway Pathway ID EC Number
(aminomethyl)phosphonate degradation PWY-7805 3.6.1.1
glyphosate degradation III PWY-7807 3.6.1.1

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MSFSNVPAGK DLPQDFNVII EIPAQSEPVK YEADKALGLL VVDRFIGTGM RYPVNYGFIP QTLSGDGDPV DVLVITPFPL LAGSVVRARA LGMLKMTDES GVDAKLVAVP HDKVCPMTAN LKSIDDVPAY LKDQIKHFFE QYKALEKGKW VKVEGWDGID AAHKEITDGV ANFKK

NT Sequence
ATGAGCTTCA GCAATGTTCC GGCCGGCAAG GATCTGCCGC AAGACTTCAA CGTGATCATC GAGATCCCGG CGCAAAGCGA GCCGGTCAAG TACGAAGCCG ACAAGGCGCT CGGCCTCCTC GTCGTCGACC GCTTCATCGG CACCGGCATG CGCTACCCGG TGAACTACGG CTTCATCCCG CAGACGCTGT CGGGCGACGG CGACCCCGTC GACGTACTCG TCATCACGCC GTTTCCGCTG CTCGCGGGCT CGGTCGTGCG CGCGCGCGCG CTCGGCATGC TGAAGATGAC CGACGAATCG GGCGTCGACG CGAAGCTCGT CGCGGTGCCG CACGACAAGG TCTGCCCGAT GACGGCCAAC CTCAAGTCGA TCGACGACGT GCCCGCGTAC CTGAAGGATC AGATCAAGCA CTTCTTCGAG CAATACAAGG CGCTCGAGAA GGGCAAGTGG GTGAAGGTCG AGGGCTGGGA CGGCATCGAC GCCGCGCACA AGGAAATCAC CGACGGCGTC GCGAACTTCA AGAAG

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