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Seattle Structural Genomics Center for Infectious Disease

BupsA.00027.a: glutaryl-CoA dehydrogenase

Target Characteristics

from organism: Burkholderia pseudomallei 1710b
most recent status: in PDB
center reference id: BupsA.00027.a
is community request: False
associated disease: Melioidosis
NIH risk group: 3
is select agent: True
NIH priority
pathogens category:
IIIB

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
BupsA.00027.a.A1.GE25002 Full length( BupsA.00027.a ) 1 395 GE25002
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
BupsA.00027.a.A1.PW25040 Full length( BupsA.00027.a ) 1 395

Structures

image of structure for 3D6B
3D6B
Deposited: 5/19/2008
Determination: XRay
Diffraction Image
Clone: BupsA.00027.a.A1.GE25002
Protein: BupsA.00027.a.A1.PW25040
image of structure for 3EOM
3EOM
Deposited: 9/28/2008
Determination: XRay
Diffraction Image
Clone: BupsA.00027.a.A1.GE25002
Protein: BupsA.00027.a.A1.PW25040
image of structure for 3EON
3EON
Deposited: 9/28/2008
Determination: XRay
Diffraction Image
Clone: BupsA.00027.a.A1.GE25002
Protein: BupsA.00027.a.A1.PW25040
image of structure for 3GNC
3GNC
Deposited: 3/16/2009
Determination: XRay
Diffraction Image
Clone: BupsA.00027.a.A1.GE25002
Protein: BupsA.00027.a.A1.PW25040
image of structure for 3GQT
3GQT
Deposited: 3/24/2009
Determination: XRay
Diffraction Image
Clone: BupsA.00027.a.A1.GE25002
Protein: BupsA.00027.a.A1.PW25040
image of structure for 3II9
3II9
Deposited: 7/31/2009
Determination: XRay
Diffraction Image
Clone: BupsA.00027.a.A1.GE25002
Protein: BupsA.00027.a.A1.PW25040

Publications by SSGCID

Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening.
Begley DW, Davies DR, Hartley RC, Hewitt SN, Myler PJ, Rychel AL, Staker BL, Stewart LJ, Van Voorhis WC
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. - 2010
volume 67, issue Pt 9, pages 1060-9
PMID: 21904051; PMCID: PMC3169403
PDB: 3D6B, 3EOM, 3EON, 3GNC, 3GQT

Citations by Others

Structure of the prolyl-acyl carrier protein oxidase involved in the biosynthesis of the cyanotoxin anatoxin-a
K Moncoq, L Regad, S Mann, A Mejean and O Ploux - Acta Crystallographica Section D Biological Crystallography, 2013 - scripts.iucr.org
cited by: 1 other
PDB: 3D6B
User-loaded SlipChip for equipment-free multiplexed nanoliter-scale experiments
L Li, W Du, R Ismagilov - Journal of the American Chemical Society, 2009 - ACS Publications
cited by: 47 others
PDB: 3D6B, 3II9
3-Sulfinopropionyl-coenzyme A (3SP-CoA) desulfinase from Advenella mimigardefordensis DPN7T: crystal structure and function of a desulfinase with an acyl-CoA …
M Schürmann, R Meijers, TR Schneider… - … Section D: Biological …, 2015 - scripts.iucr.org
cited by: 2 others
PDB: 3EOM
Update 1 of: Proteases universally recognize beta strands in their active sites
PK Madala, JDA Tyndall, T Nall, DP Fairlie - Chemical Reviews, 2011 - ACS Publications
cited by: 81 others
PDB: 3EON
In silico modeling of cooperative ligand binding
M Vass - theop11.chem.elte.hu
PDB: 3GQT
Rare Sidechain Conformations in Proteins and DNA
BJ Hintze - 2015 - search.proquest.com
PDB: 3II9

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_129299
PATRIC ID: fig|320372.6.peg.3374
RefSeq: YP_334609
UniProt: Q3JP94

Enzyme & Pathway Information

Pathway Pathway ID EC Number
1.3.8.6
1.3.99.7

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MAAATFHWDD PLLLDQQLAD DERMVRDAAH AYAQGKLAPR VTEAFRHETT DAAIFREMGE IGLLGPTIPE QYGGPGLDYV SYGLIAREVE RVDSGYRSMM SVQSSLVMVP IFEFGSDAQK EKYLPKLATG EWIGCFGLTE PNHGSDPGSM VTRARKVPGG YSLSGSKMWI TNSPIADVFV VWAKLDEDGR DEIRGFILEK GCKGLSAPAI HGKVGLRASI TGEIVLDEAF VPEENILPHV KGLRGPFTCL NSARYGIAWG ALGAAESCWH IARQYVLDRK QFGRPLAANQ LIQKKLADMQ TEITLGLQGV LRLGRMKDEG TAAVEITSIM KRNSCGKALD IARLARDMLG GNGISDEFGV ARHLVNLEVV NTYEGTHDIH ALILGRAQTG IQAFF

NT Sequence
ATGGCTGCCG CAACCTTCCA CTGGGACGAT CCGCTGCTGC TCGACCAGCA GCTCGCCGAC GATGAGCGCA TGGTGCGCGA CGCCGCGCAC GCTTACGCGC AAGGCAAGCT CGCGCCGCGC GTGACCGAAG CGTTCCGCCA CGAGACCACC GACGCGGCGA TCTTCCGTGA AATGGGCGAG ATCGGCCTCC TCGGCCCGAC GATCCCCGAG CAGTACGGCG GCCCCGGCCT CGACTACGTG AGTTACGGGC TCATCGCGCG CGAAGTCGAG CGCGTCGATT CGGGTTATCG GTCGATGATG TCGGTGCAAT CGTCGCTCGT GATGGTGCCG ATCTTCGAAT TCGGCTCCGA CGCGCAGAAG GAAAAGTACC TGCCGAAGCT CGCGACGGGC GAATGGATCG GCTGCTTCGG GCTGACCGAG CCGAACCACG GCTCCGATCC CGGCAGCATG GTCACGCGCG CGAGGAAGGT GCCGGGCGGG TACTCGCTGT CCGGCTCGAA GATGTGGATC ACGAATTCGC CGATCGCCGA CGTGTTCGTC GTCTGGGCCA AGCTCGACGA AGACGGCCGC GACGAGATTC GCGGCTTCAT TCTCGAAAAG GGCTGCAAAG GGCTGTCGGC GCCGGCGATC CACGGCAAGG TGGGGCTGCG CGCGTCGATC ACGGGTGAAA TCGTGCTCGA CGAAGCGTTC GTCCCCGAAG AGAACATCCT GCCGCACGTG AAGGGGCTGC GCGGCCCGTT CACGTGCCTG AACTCGGCGC GCTACGGCAT CGCGTGGGGG GCGCTCGGCG CGGCCGAATC GTGCTGGCAC ATCGCGCGCC AATATGTGCT CGATCGCAAG CAGTTCGGCC GCCCGCTCGC CGCGAACCAG TTGATCCAGA AGAAGCTCGC CGACATGCAG ACCGAGATCA CGCTCGGCCT GCAAGGCGTG CTGCGGCTCG GCCGGATGAA GGACGAAGGC ACCGCCGCCG TCGAGATCAC GTCGATCATG AAGCGCAATT CGTGCGGCAA GGCGCTCGAC ATCGCCCGCC TCGCCCGCGA CATGCTGGGC GGCAATGGCA TCTCGGACGA ATTCGGCGTC GCGCGCCACC TCGTGAACCT CGAGGTGGTG AACACGTACG AAGGTACGCA CGACATCCAC GCGCTGATTC TCGGCCGCGC GCAGACGGGG ATTCAGGCGT TCTTC

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