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BupsA.00032.a: S-adenosyl-L-homocysteine hydrolase

Target Characteristics

from organism: Burkholderia pseudomallei 1710b
most recent status: in PDB
center reference id: BupsA.00032.a
is community request: False
associated disease: Melioidosis
NIH risk group: 3
is select agent: True
NIH priority
pathogens category:
IIIB

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
BupsA.00032.a.A1.GE25007 Full length( BupsA.00032.a ) 1 473 GE25007
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
BupsA.00032.a.A1.PW25045 Full length( BupsA.00032.a ) 1 473

Structures

image of structure for 3D64
3D64
Deposited: 5/18/2008
Determination: XRay
Diffraction Image
Clone: BupsA.00032.a.A1.GE25007
Protein: BupsA.00032.a.A1.PW25045
image of structure for 3GLQ
3GLQ
Deposited: 3/12/2009
Determination: XRay
Diffraction Image
Clone: BupsA.00032.a.A1.GE25007
Protein: BupsA.00032.a.A1.PW25045

Citations by Others

Crystal structures of S-adenosylhomocysteine hydrolase from the thermophilic bacterium Thermotoga maritima
Y Zheng, CC Chen, TP Ko, X Xiao, Y Yang… - Journal of structural …, 2015 - Elsevier
cited by: 5 others
PDB: 3D64
An enzyme captured in two conformational states: crystal structure of S-adenosyl-l-homocysteine hydrolase from Bradyrhizobium elkanii
T Manszewski, K Singh, B Imiolczyk - Section D: Biological , 2015 - scripts.iucr.org
cited by: 3 others
PDB: 3D64
An Inexpensive Method for Selecting Receptor Structures for Virtual Screening
Z Huang, CF Wong - Journal of chemical information and , 2015 - ACS Publications
cited by: 1 other
PDB: 3D64, 3GLQ
PEPTIDOMIMETIC COMPOUNDS
RT Skerlj, AC Good - US Patent 20,150,353,606, 2015 - freepatentsonline.com
PDB: 3D64
Crystallization and preliminary X-ray diffraction analysis of the S-adenosylhomocysteine hydrolase (SAHH) from Thermotoga maritima
M He, Y Zheng, CH Huang, G Qian, X Xiao… - Structural Biology and …, 2014 - journals.iucr.org
cited by: 1 other
PDB: 3D64
S-adenosyl-L-homocysteine hydrolase and methylation disorders: Yeast as a model system
O Tehlivets, N Malanovic, M Visram… - … et Biophysica Acta (BBA …, 2013 - Elsevier
cited by: 20 others
PDB: 3D64
Hidden Relationship between Conserved Residues and Locally Conserved Phosphate-Binding Structures in NAD (P)-Binding Proteins
CY Wu, YH Hwa, YC Chen, C Lim - The Journal of Physical Chemistry, 2012 - ACS Publications
cited by: 6 others
PDB: 3D64
Biological activity on cordycepin and cordycepin triphosphate based on the reverse molecular docking
Gong, Guocai , Ling et al. - (J. Hunan Agr. Un. (Nat Sci) ), 2016 - xb.cnjournals.com
PDB: 3GLQ
Inexpensive method for selecting receptor structures for virtual screening
Z Huang, CF Wong - Journal of chemical information and modeling, 2015 - or.nsfc.gov.cn
cited by: 4 others
PDB: 3GLQ
High-resolution structures of complexes of plant S-adenosyl-L-homocysteine hydrolase (Lupinus luteus)
K Brzezinski, Z Dauter, M Jaskolski - Acta Crystallographica Section D Biological Crystallography, 2012 - scripts.iucr.org
cited by: 5 others
PDB: 3GLQ
Functional Prediction of Binding Pockets
M Kontoyianni, CB Rosnick - Journal of chemical information and modeling, 2012 - ACS Publications
cited by: 5 others
PDB: 3GLQ

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_127233
PATRIC ID: fig|320372.6.peg.57
RefSeq: YP_331474
UniProt: Q3JY79

Enzyme & Pathway Information

Pathway Pathway ID EC Number
L-methionine degradation I (to L-homocysteine) METHIONINE-DEG1-PWY 3.3.1.1
S-adenosyl-L-methionine cycle II PWY-5041 3.3.1.1
superpathway of L-methionine salvage and degradation PWY-5328 3.3.1.1
superpathway of L-cysteine biosynthesis (mammalian) PWY-6292 3.3.1.1

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MNAAVIDSHS AQDYVVADIA LAGWGRKELN IAETEMPGLV QIRDEYKAQQ PLKGARIAGS LHMTIQTGVL IETLKALGAD VRWASCNIFS TQDHAAAAIV EAGTPVFAFK GESLDEYWEF SHRIFEWPNG EFANMILDDG GDATLLLILG SKAEKDRSVI ARPTNEEEVA LFKSIERHLE IDGSWYSKRL AHIKGVTEET TTGVHRLYQM EKDGRLPFPA FNVNDSVTKS KFDNLYGCRE SLVDGIKRAT DVMIAGKIAV VAGYGDVGKG CAQSLRGLGA TVWVTEIDPI CALQAAMEGY RVVTMEYAAD KADIFVTATG NYHVINHDHM KAMRHNAIVC NIGHFDSEID VASTRQYQWE NIKPQVDHII FPDGKRVILL AEGRLVNLGC ATGHPSFVMS NSFTNQTLAQ IELFTRGGEY ANKVYVLPKH LDEKVARLHL ARIGAQLSEL SDDQAAYIGV SKAGPFKPDH YRY

NT Sequence
ATGAACGCCG CTGTCATCGA TTCCCATTCC GCACAAGATT ACGTCGTCGC CGATATCGCG CTGGCCGGCT GGGGCCGCAA GGAACTGAAC ATCGCCGAGA CCGAGATGCC CGGGCTCGTG CAGATCCGCG ACGAATACAA GGCGCAGCAG CCGCTGAAGG GCGCGCGCAT CGCCGGCTCG CTGCACATGA CGATCCAGAC GGGCGTGCTG ATCGAGACGC TGAAGGCGCT CGGCGCGGAC GTTCGCTGGG CGTCGTGCAA CATCTTCTCG ACGCAGGACC ACGCGGCCGC CGCGATCGTC GAGGCCGGCA CGCCCGTCTT CGCGTTCAAG GGCGAATCGC TCGACGAATA CTGGGAGTTC TCGCACCGCA TCTTCGAATG GCCGAACGGC GAGTTCGCGA ACATGATCCT TGATGACGGC GGCGACGCAA CGCTGCTGCT GATCCTCGGC TCGAAGGCCG AGAAGGACCG CTCGGTGATC GCCCGGCCGA CCAACGAGGA AGAAGTCGCG CTCTTCAAGT CGATCGAGCG CCACCTCGAA ATCGACGGCA GCTGGTACTC GAAGCGCCTC GCGCACATCA AGGGCGTGAC CGAAGAGACG ACGACGGGCG TGCACCGCCT GTACCAGATG GAAAAGGACG GCCGCCTGCC GTTCCCGGCG TTCAACGTCA ACGATTCCGT GACGAAATCG AAGTTCGACA ACCTGTACGG CTGCCGCGAG TCGCTCGTCG ACGGCATCAA GCGCGCGACC GACGTGATGA TCGCGGGCAA GATCGCGGTG GTCGCGGGCT ACGGCGACGT GGGCAAGGGC TGCGCGCAAT CGCTGCGCGG CCTGGGCGCG ACCGTGTGGG TGACCGAAAT CGATCCGATC TGCGCGCTGC AGGCGGCGAT GGAAGGCTAC CGCGTCGTGA CGATGGAATA CGCGGCCGAC AAGGCCGACA TCTTCGTGAC GGCGACCGGC AACTACCACG TGATCAACCA CGATCACATG AAGGCGATGC GCCATAACGC GATCGTCTGC AACATCGGTC ACTTCGATTC GGAAATCGAC GTCGCGTCGA CCCGCCAGTA CCAGTGGGAA AACATCAAGC CGCAGGTCGA CCACATCATC TTCCCGGACG GCAAGCGCGT GATCCTGCTG GCCGAAGGCC GCCTCGTGAA CCTCGGCTGC GCGACCGGCC ACCCGTCGTT CGTGATGTCG AACTCGTTCA CGAATCAGAC CCTCGCGCAG ATCGAGCTGT TCACGCGCGG CGGCGAGTAC GCCAACAAGG TGTACGTGCT GCCGAAGCAT CTCGACGAAA AGGTCGCGCG CCTGCACCTC GCGCGCATCG GCGCGCAGCT CTCCGAGCTG TCGGACGATC AGGCGGCGTA CATCGGCGTG TCGAAGGCGG GCCCGTTCAA GCCGGATCAC TATCGTTAC

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