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CoimA.19525.a: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)

Target Characteristics

from organism: Coccidioides immitis RS
most recent status: cloned
center reference id: CoimA.19525.a
is community request: True
associated disease: California disease, Desert rheumatism, San Joaquin valley fever, Valley fever
NIH risk group: 2
is select agent: True
NIH priority
pathogens category:
II

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

External Resources

Resource Reference ID
EuPathDB: FungiDB:CIMG_04488
UniProt: J3KDL1

Enzyme & Pathway Information

Pathway Pathway ID EC Number
superpathway of ergosterol biosynthesis I ERGOSTEROL-SYN-PWY 1.1.1.34
superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) PWY-5910 1.1.1.34
Methanobacterium thermoautotrophicum biosynthetic metabolism PWY-6146 1.1.1.34
mevalonate pathway II (archaea) PWY-6174 1.1.1.34
superpathway of cholesterol biosynthesis PWY66-5 1.1.1.34
isoprene biosynthesis II (engineered) PWY-7391 1.1.1.34
mevalonate pathway III (archaea) PWY-7524 1.1.1.34
mevalonate pathway I PWY-922 1.1.1.34

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MRGSSLLPRR FREVTSADSA DAGWMNRHVT KLLQVVSRRA CFHPIHTIVV IALLASTTYV GLLDGTLFDS VKQANYSPGY LDVDTLLAGG RNLRLGQQTG WRWQVDDTFK LGDSDAARHL ALTTFVFPDS SARSPQIAPL AENVPLPPNS SARSVPHTPS LLAPISQDSS LAFAVPYDEI SPFLQAVREI PDSSGLKDGT EQKRWIMKAA RSPVSGSRAA LRIWLTEAWT SFIDLLKHAE TIDILIMVLG YLSMHLTFVS LFLSMRRLGS KSWLAATVLI SGGFAFLFGL LVTTKLGVPI NMVLLSEGLP FLVVTIGFEK PIILTKAVLS ASLGGSSQSA AGQGSDARKA PPVRSIQDAI QHAVKNKGFE IVRDYCIEIG ILVIGAASGV QGGLRQFCFL AAWILFFDCA LLFTFYTTIL CIKLEINRIK RHVALRKALE EDGITRRVAE NVASSNDWPR VNGGENGQGS NVSSSGIFGK KVRASSVPKF KFLMVGGFVL VNVLNLCTIP FRSRQDGQIM PALAKLSNVL APAPIDPFKV AENGLDAIYV NAKSQGLETV VTVLPPIKYK LEYPSVHYAE PDTSVFDIEY TDVVGGRVIE SLLKSLDDPI ISKWIIAALT LSLVLNGYLF NAARWSIKEP ETEKEPEKQQ PEPLPKPVVV RQPVVKADGS VRTREECEQM LKDKLAYLLD DEELIDLSIR GKIPGYALEK TMECEGMSRT DAFTRAVKIR RAVVSRNAST SATTGSLEYS KVPYQHYNYS LVHGACCENV IGYLPLPLGV AGPLTIDGQS FFIPMATTEG VLIASTSRGC KAINAGGGAV TVITGDGMTR GPCVGFPSLA RAGAAKVWLD SEEGQTVMKN AFNSTSRFAR LQSMKTALAG TYLYIRFKTT TGDAMGMNMI SKGVEKALHV MATEAGFEDM ATISVSGNFC TDKKPAAVNW IDGRGKSVVA EAVIPGDVVK SVLKSNVDAL VELNISKNLI GSAMAGSVGG FNAHASNIVT ALFLATGQDP AQNVESSNCI TIMKNVNGNL HISVSMPSIE VGTIGGGTIL EAQSAMLELL GVRGSHPTTP GDNARRLARI VGAAVLAGEL SLCSALAAGH LVRAHMAHNR AAPPPTRSMT PVSAAVATTL TDKK

NT Sequence
atgagaggct cctccctgct ccctcgtcgt tttcgcgagg tcacctctgc cgattctgcg gatgctggat ggatgaatcg ccatgtgacg aagctgctgc aggtggtttc gcgtcgagct tgcttccatc ctatccatac gatcgtcgtc attgctctgc tcgcgagtac tacatacgtg ggtttgctgg atggtacatt atttgattct gtgaagcaag caaattatag tcccggctac ctcgatgtcg atacgcttct tgcgggtgga agaaacctac gacttggcca gcagacgggc tggagatggc aagtcgacga tacgttcaag ctgggagaca gtgacgctgc acgacatcta gccttgacca ctttcgtttt ccctgactct tcggcccgtt cgcctcagat agctccgctg gcggagaatg tgccgctccc tcccaattcc tcagcccgct cggttccaca tacccctagc ctcctggctc caatctcgca ggattcttct cttgctttcg cggtccctta cgatgaaata tctcccttcc ttcaagctgt acgagagatc cctgactcat ccggtctgaa agatggaacg gagcaaaaga gatggataat gaaggccgct cgcagcccag tgtctggctc gcgcgccgct ttgcgaattt ggctgaccga agcctggacg tcctttattg acctattaaa gcatgcggaa acgattgaca tacttatcat ggttctggga tacctctcca tgcatcttac ctttgtgtct ttgtttctgt ctatgagacg acttggatcc aaatcctggc ttgctgccac ggtactcatt tctggcgggt tcgctttcct gttcggctta ctcgtcacta ccaagctcgg tgttccgatc aatatggtgc tgctttctga ggggctgcca ttccttgttg ttacaattgg atttgagaag ccgattatcc tcaccaaagc tgtactttcg gcatctttgg gaggctccag ccaaagcgct gcgggtcaag ggagtgatgc tcgaaaggct cctcctgtcc gatccatcca agacgcgatc caacatgctg ttaagaacaa aggctttgag atcgttagag attattgcat agagatcggt attttggtga tcggtgctgc ttctggcgtc caaggaggcc ttcgacagtt ctgctttctc gctgcctgga ttttattttt tgactgcgcg ctgctgttca cattttacac tacaatcctt tgcatcaagc ttgagattaa ccgaattaaa cgccatgtgg cacttcgaaa agcccttgaa gaagatggaa ttactcgtcg cgttgcagaa aatgtcgctt cgagcaacga ttggccaagg gtgaatggag gagagaacgg ccaaggctca aacgtgagct ccagtggtat tttcggcaaa aaagtcaggg cgagtagtgt ccccaagttt aagttcctca tggttggagg ctttgtgttg gtcaatgtcc tcaatctatg caccattccc ttccgcagcc gacaggatgg ccagattatg ccagcattgg caaagttgtc caacgtccta gcaccggcgc cgatcgaccc attcaaagtc gctgaaaatg gcctcgatgc gatctatgtg aacgcaaaga gccaggggtt agagacagta gttacggttc tgccgcccat caagtataag ctcgagtacc cgtctgttca ctatgcagag cccgatacta gtgtgttcga tattgagtat acagacgtcg ttggtggtag ggttatcgag agtctcctaa agagcttgga cgaccccata atcagcaaat ggatcattgc cgcgctgacc ttgagcttgg ttttgaatgg ctatctcttc aacgccgcac gctggagcat aaaagagcct gaaacagaga aagaacccga gaaacaacaa cctgaacctc tccccaagcc agttgtggtc agacaaccag ttgtgaaggc agacggctcg gtcaggaccc gtgaagaatg cgaacaaatg ctgaaagaca agcttgctta ccttttggat gatgaagagc ttattgacct gtcaattcga ggcaagattc ccggatatgc tcttgaaaag actatggagt gtgaaggcat gagccgcaca gatgcgttca caagagctgt taagattcga agagcggttg tgtcaagaaa cgcgagtacc tcagccacga ccggatccct tgaatattcc aaggttcctt accagcatta caattactct cttgtccacg gtgcttgctg cgaaaacgtc attggttatc tccctctccc gctaggagtt gcaggaccct tgaccattga tggccagagc ttcttcattc ctatggcaac aacagagggt gtccttatag ctagtacgag ccgcggatgc aaggccatca atgccggagg cggtgcagtt actgttatca ccggtgacgg tatgaccaga ggaccgtgcg tgggcttccc aagtcttgct cgtgcgggcg ctgccaaagt ctggcttgac tcagaggaag gacaaaccgt catgaagaat gcattcaatt caacgagtcg ctttgcaaga ctccagtcta tgaagactgc tcttgctgga acttacctgt atatccgatt caagacgaca accggcgatg ccatgggtat gaacatgatc tcgaaaggtg ttgagaaggc ccttcatgtc atggccacgg aagctgggtt cgaggatatg gccaccatct ccgtgtccgg aaatttctgc acggataaga agcccgcggc tgtcaactgg atcgatggtc gaggcaagtc tgttgtcgca gaagccgtca tcccaggaga cgttgtgaag agcgtcttaa agagcaacgt cgatgccttg gtcgagctta atatcagcaa gaacttgatc ggaagcgcca tggctggcag cgttggtggg ttcaacgctc atgcttccaa catcgtcacg gcattgttcc tcgccaccgg tcaagacccg gctcagaatg tggagagtag caattgtatc actattatga agaacgtgaa cggtaatctt cacatcagcg tttccatgcc gtccatcgaa gtcggcacga tcggaggcgg taccatcctc gaagcacaat ccgcgatgct cgaactcctg ggtgtgcgtg gctctcaccc aactacccct ggtgacaacg ctcgtcgtct cgcacgcatc gtgggtgccg ctgtgcttgc cggagagctc agtctctgca gcgcccttgc cgcaggacac ctggtcaggg cacacatggc tcacaaccgg gcagctcctc caccgacacg gtcgatgacc cccgtttcgg ccgccgtggc tacgacgttg acggataaaa aatga

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