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Seattle Structural Genomics Center for Infectious Disease

CrneC.00830.a: Adenylyl-sulfate kinase (EC 2.7.1.25)

Target Characteristics

from organism: Cryptococcus neoformans var. grubii serotype A (H99 / ATCC 208821 / CBS 10515 / FGSC 9487)
most recent status: in PDB
center reference id: CrneC.00830.a
is community request: True
associated disease: Pneumonia-like illness
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
unclassified

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
CrneC.00830.a.B1.GE41253 full length 1 203 GE41253
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
CrneC.00830.a.B1.PS38292 full length 1 203

Structures

image of structure for 6B8V
6B8V
Deposited: 10/9/2017
Determination: XRay
Diffraction Image
Clone: CrneC.00830.a.B1.GE41253
Protein: CrneC.00830.a.B1.PS38292
image of structure for 6C6B
6C6B
Deposited: 1/18/2018
Determination: XRay
Diffraction Image
Clone: CrneC.00830.a.B1.GE41253
Protein: CrneC.00830.a.B1.PS38292

External Resources

Resource Reference ID
EuPathDB: FungiDB:CNAG_02202
UniProt: J9VMZ3

Enzyme & Pathway Information

Pathway Pathway ID EC Number
sulfate activation for sulfonation PWY-5340 2.7.1.25
superpathway of L-methionine biosynthesis (by sulfhydrylation) PWY-5345 2.7.1.25
superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) PWY-821 2.7.1.25
assimilatory sulfate reduction I SO4ASSIM-PWY 2.7.1.25
superpathway of sulfate assimilation and cysteine biosynthesis SULFATE-CYS-PWY 2.7.1.25

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MATNITFHPG AVTQDERDTL LGQKGCTVWL TGLSASGKST IATALEQHLL HKKLHAYRLD GDNIRFGLNK DLGFDQASRV ENIRRIGEVS LLFALSSTIS VTAFISPYIS DRQLARELHE KHSSAIPFIE VFIDAPLSVV EQRDPKGLYK KARAGEIKDF TGISAPYEAP ANPEIHIRTD EVDVAGAVEI ITKYLADNGL IPA

NT Sequence
atggccacaa acatcacctt ccaccccgga gccgtcaccc aggacgagcg agataccctt ctcggccaga agggctgtac cgtctggctc actggtttga gcgcttccgg caagtctacc atcgcgacag cacttgaaca gcacttgctc cataaaaagc tccatgcgta taggttggac ggtgataaca tccgattcgg tctcaacaag gacctcggct ttgaccaggc ttcccgagtg gaaaacattc gacgaatcgg cgaagtctca ctcctctttg cactctcctc caccatctcc gtcacggcct tcatctcccc atacatctct gaccgacaac tcgcccgaga gttgcacgaa aaacactctt ccgccattcc cttcatcgaa gtcttcatcg acgctcccct ctccgtcgtc gagcagaggg accccaaggg cctgtacaaa aaggcaaggg ccggtgagat caaggacttt acaggtatct cggcgccgta tgaggctcct gcgaatcccg agatccacat caggaccgat gaggtggacg tggccggtgc agtcgagatc attacaaagt acctcgccga caatggtctt atccctgctt aa

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