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Seattle Structural Genomics Center for Infectious Disease

CrneC.19525.a: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)

Target Characteristics

from organism: Cryptococcus neoformans var. grubii serotype A (H99 / ATCC 208821 / CBS 10515 / FGSC 9487)
most recent status: soluble
center reference id: CrneC.19525.a
is community request: True
associated disease: Pneumonia-like illness
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
unclassified

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
CrneC.19525.a.B2.GE41077 soluble domain 722 1224 GE41077
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

External Resources

Resource Reference ID
EuPathDB: FungiDB:CNAG_06534
UniProt: J9VT67

Enzyme & Pathway Information

Pathway Pathway ID EC Number
superpathway of ergosterol biosynthesis I ERGOSTEROL-SYN-PWY 1.1.1.34
superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) PWY-5910 1.1.1.34
Methanobacterium thermoautotrophicum biosynthetic metabolism PWY-6146 1.1.1.34
mevalonate pathway II (archaea) PWY-6174 1.1.1.34
superpathway of cholesterol biosynthesis PWY66-5 1.1.1.34
isoprene biosynthesis II (engineered) PWY-7391 1.1.1.34
mevalonate pathway III (archaea) PWY-7524 1.1.1.34
mevalonate pathway I PWY-922 1.1.1.34

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MLRQTLVSLS SLAASAPIEV ITTTFIFATL AYFQLLHAIK GSEFFNVPSV SPPSRPAHFV RLSHQPTSED ASYILPSSHG VAGSSWVGDV ESKREWTPIS PSDFRKILEQ NALGGYTFPI EAGGNTSGEK ASVAIVKQVV VTREGAEEPI DEFEQWLLNV LSVEVDGEKY TYRDLCFNTS DHPSFVSHPL YPSQSTLTMF LQPPSPSDPT LTYLNRLNRL PAFTLSNSTT AFQLLPPTGA SWGFLPSIDG VGLFSKLGEG MISGQGESYP MQNVRWFAYA ARALVGRFWT LAKNADSADI FVVLLGYIVM HGVFVNLFIG MRKLGSSFWI PVATLCSSTF AFLVALLSAY LLDLPVDPIC LSEAIPFLVI TVGFDKPYHL AKAVLQNPDI DPVPSSPEPS TAGYSGELSK DPNSGSTLGL DLGTLHKELM PLERLQRLAE GQVKWVAPVA AKKIVVDAVR TSGVRIVRDY VLEIIALCVG AASGIGGLRE FCYLAALIMA VDCVFLFTFY VAILSVMVEV HRIKLIRGNR RVKSVKRVSS SASLNSHGNG NGNGSTTNTS SSTSSPSTKR SFWSRSPSSE REDQPQNPLV RLKLLLIISF LTLHVLNLCT TLTEQTALKR HSTHSGAEIT SRAMLNPRGI SLSPVLQALY ENQPPETDLA VQVMPPTQIL MTSETFIPSR LSSFDQFMSE WTLLVGDPVL SKWIVVFLAI SVLLNGYLLK GIALNSMGGK GPVAAAAQAL AGIFDAERGQ RALRESTPRG RKTELPAHMV GTNASTSTRD GDSTPRVEEV GKVTATHTVN VPIIKEPRIP SPSFPSASDD SALTFGRRSF EECVEIYAGG VGANNLSDEE IILLVQKGKI APYGLEKALK NLERAVRIRR AVISRSSLTK SLETSLLPMA DYDYKQVIGA CCENVIGYLP LPVGIAGPLN IDGQLLHIPM ATTEGTLVAS TSRGCKALNA GGGVTTVLTH DAMTRGPAID FPNIVQAAQA RLWIDSPDGY ATLKAAFEST SRFAKLQTLE CALAGRTLYV RFATQTGDAM GMNMISKGVE KALEVLRNHF PDMHVLALSG NYCTDKKPAA INWIEGRGKS VVAEAVVPGH VVKTVLKTTV KDLCNLNIKK NLIGSAMAGS IGGFNAHAAN ILTAMYLACG QDPAQNVESS NCMTLMEPIN DGEDLLISCS MPSVEVGTVG GGTILSPQRA MLDMLGVAGA HATSPGANAQ RLARIIVAAV MAGELSLMSA LAAGHLIQAH MKHNRSTPAT PGAVTPFGGI TPLREAVLIN GPGAK

NT Sequence
atgcttcgcc aaacactcgt ctctctctcg tccttggccg cctccgcgcc catcgaggtc atcaccacca ccttcatctt cgccaccctc gcatacttcc agctcctcca cgcgatcaag ggctccgagt ttttcaacgt cccttccgtc tccccgcctt cccgccccgc ccatttcgtc cgtctctccc accagcccac ctctgaagac gcgtcctaca tccttcccag ctcgcacggt gtcgccggga gcagctgggt gggcgatgtc gagtccaaac gcgaatggac acccatctct ccatctgatt tccgaaaaat cctcgaacag aatgctcttg gtggatacac ctttcccatc gaggcaggcg gtaacacttc tggtgaaaag gccagcgtcg cgatcgtcaa gcaggtcgtc gtcacgcgtg aaggcgcaga ggagccaatt gatgagtttg aacaatggtt attaaatgtg ctgagtgtag aagtcgacgg ggaaaagtac acttatcgcg acttgtgctt caacacctct gaccaccctt cattcgtctc tcaccctctc tacccatccc aatccaccct caccatgttc ctccaacctc cctcaccttc agaccctact ctcacctacc tcaacaggct taaccgcctt ccggcgttta ccctctcaaa ctcgaccacc gctttccaac tcttaccccc aacgggcgcg agctgggggt tcttacccag tatcgatggt gtcggtttgt tctccaagtt gggcgaggga atgatctctg gtcaagggga gagttacccc atgcagaacg ttaggtggtt tgcctatgct gctagagcgt tggtcggcag attttggact ttggcaaaga atgccgactc tgctgatatt tttgtggtgc ttctcggcta catcgtcatg cacggtgtgt ttgtcaactt gttcatcggt atgcgcaaac tcggaagctc tttctggatc cctgttgcaa ccctctgctc ttcaacattc gcattcctcg tcgccctcct ctctgcttat ctcctcgacc tccccgtcga ccccatctgt ctttctgaag cgatcccctt cctcgtcatc acagtcggct ttgacaaacc ctaccacctc gccaaagccg tcttgcaaaa ccccgatatc gatcccgtcc cttcatctcc cgaaccttct actgctggtt acagcggcga attgtcaaaa gatcccaact ctggctccac tttaggactt gatcttggga ctttgcacaa ggaacttatg cctcttgagc gtcttcagcg attggcggaa ggacaggtca agtgggtcgc ccctgtggct gccaagaaga ttgtagtcga cgctgtgagg acatcgggtg tgaggattgt tagggattac gttttggaga tcattgcgct ttgcgtcggt gcagctagtg ggatcggtgg tctgagagaa ttttgctatc ttgccgcatt aatcatggcc gtcgattgtg tcttcctctt cacgttttac gttgccatcc tcagcgtcat ggtcgaagtt caccgtatca agcttattcg aggtaaccgc cgagtcaaat ctgtcaaacg cgtctctagc tctgcctctc ttaacagcca cggcaacggc aacggcaacg gcagcactac caacaccagc agcagcactt ccagtccctc cactaagcga agcttttggt ctcgctcccc ctccagcgag agagaagacc aacctcaaaa ccctcttgtt cgactaaaac tcctcttgat catctctttc ctaactctcc acgttctcaa cctctgtacg accctcaccg agcaaaccgc cttaaaacgt cactccaccc attctggcgc tgaaatcacc tctcgcgcga tgctcaaccc ccgcggtatc tcactctccc ccgtcctcca ggcgctctac gagaatcaac cccccgagac tgacttggcc gtccaagtca tgccccctac tcaaattctc atgacaagcg aaacctttat ccccagccgc ttgtcctctt tcgaccagtt tatgagcgaa tggacgttac tcgtgggtga tcccgtgctg agcaagtgga ttgtcgtctt cctcgcgatc agtgtattat tgaatggcta tctcttaaag ggaattgcgt tgaattcaat gggcggcaaa gggccagtgg cggcggcggc tcaagcgtta gctgggatct ttgatgctga gcgaggacag agagctcttc gagagtcgac gccacgaggg aggaagaccg agttgcctgc gcacatggtt ggtacaaatg caagtactag tactcgggat ggggattcga cacctcgagt tgaagaagtt ggcaaggtta ctgctaccca cactgtcaac gtacctatca tcaaggaacc tcgtatccct tccccttcat tcccctctgc ttccgatgac tctgctctta cctttggccg acgatcgttt gaggaatgtg tcgagattta cgcaggcggc gttggcgcca acaatctttc cgacgaggaa attatcttgc tcgtccaaaa gggcaagatt gcgccgtacg gccttgaaaa agctttaaag aacctcgaac gagctgtccg aattcgacga gccgtcatct cccgatccag tctcaccaaa tctcttgaga cgagtttgct ccctatggca gactatgatt acaagcaagt catcggtgca tgctgcgaga atgtgattgg ttaccttcct cttccggtcg gcatcgccgg tcctctcaac attgatggtc aactgttgca tatccccatg gctaccaccg aaggtactct tgtcgcttct acatctcgag gatgtaaagc cctcaacgcc ggtggcggcg tcacaaccgt cctcactcac gacgccatga cccgcggccc agctatcgat ttccccaaca ttgtccaagc tgcccaagca cgtctatgga tcgattcgcc cgacgggtac gccaccctca aagctgcctt tgagtccacc tctcgattcg ccaaactcca gactctggaa tgcgctttgg caggtcggac gttgtatgtg aggtttgcga cccagaccgg tgacgcgatg ggtatgaaca tgatctccaa gggggtcgaa aaggctctcg aagtcctgcg caatcatttc cccgatatgc acgtcctcgc tctttccgga aactattgta ccgacaagaa accggcggcg atcaattgga ttgaagggag aggtaagagc gtggtggcgg aagcggtggt gcccggccat gtggtgaaga cggtgttgaa gacgacagtg aaggatttgt gtaatttgaa catcaagaag aatttgattg gaagtgcgat ggcgggaagt ataggaggat ttaacgctca cgcggcgaat atcttgactg ccatgtacct cgcgtgcggt caggatccgg ctcagaacgt tgaaagttcc aactgtatga ctcttatgga accgatcaac gacggcgaag accttctcat ctcatgttcc atgccttccg ttgaagtcgg caccgtcggc ggcggtacca tactttcccc ccagcgcgcc atgctcgaca tgctcggcgt cgctggtgcc catgccactt cgccaggtgc aaacgcccaa cgtctcgctc gaatcattgt cgcagccgtc atggctggtg aactgagttt gatgagtgcg ctcgctgcgg gtcatttgat tcaggcgcat atgaagcata ataggagtac gcctgcgacg ccgggggcag tgacgccgtt tggagggata acgccgttga gggaggctgt gttgattaat ggcccgggag cgaagtga

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