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Seattle Structural Genomics Center for Infectious Disease

EnhiA.18720.a: Acetyl-CoA synthetase

Target Characteristics

from organism: Entamoeba histolytica HM-1:IMSS
most recent status: target approved
center reference id: EnhiA.18720.a
is community request: True
associated disease: Amoebic dysentery
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIB

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

External Resources

Resource Reference ID
EuPathDB: AmoebaDB:EHI_178960
UniProt: Q9NAT4

Enzyme & Pathway Information

Pathway Pathway ID EC Number
L-glutamate degradation V (via hydroxyglutarate) P162-PWY 6.2.1.13
pyruvate fermentation to acetate and alanine PWY-5096 6.2.1.13
pyruvate fermentation to acetate III PWY-5483 6.2.1.13
acetate and ATP formation from acetyl-CoA II PWY-5535 6.2.1.13
crotonate fermentation (to acetate and cyclohexane carboxylate) PWY-7401 6.2.1.13
benzoate fermentation (to acetate and cyclohexane carboxylate) PWY-7402 6.2.1.13

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MQFEPLFNPK SVPVIGASDR KESVGYAVMN NMIKGGYKGN LYPVGRKPEL FGKKCYAKIG KIEEKVDLAV IAIPAKFVPG VCIECGEAGV KGLIIITAGF AEAGEEGKKM CIEIQATCQK YNMRMIGPNC LGIINPRDGV NASFASVMPE AGGVAFISQS GALCTAILDW AANQHVGFSY FVSIGSSIDT DYADLFEFFA KDPKVTSILM YIESIKDAKK FVLRAREFAA DKPIILLKAG KSSEGAAAAM SHTGSLAGND AVYDAVFDRC GCIRVDSICD LWDCAHVLAT QNIPQNNRLC IITNAGGPGV ISTDRLVSVH GHLAKLSEST MNELNAFLSP FWSHSNPVDV LGDATAGVYQ KTLDIVIKDP QIDGVVVVLT PQAMTDPVAV AKSLVEHGPY QNQSLPHGWV NQKSEAGVKI LEEGKIPNFE TPERAVTAFG YIMRHPDIAA KLKEIPKYLD VQVDYEGAKK LIADVVADGR TTFTEYEGKM MFSKYGIPIK GMAKASTEDE AVAEAMKIGT PVVMKILSPD IMHKTDVGGV KVKLTTEEEI RKAYRDIMTS VKEKKPEARI HGVLLEKMVG FKYECIIGCK KDPLFGPVIV FGMGGVTVEL YKDTNIALPP IGLQEADRLI DGTKISKLLR GYRGMPACDV EGLKKILVQF SKMIMDFPEI SEVDINPLAV SYEEFLVLDA KIVLDKNMIG KEVPKYSHLV IQP

NT Sequence
atgcaatttg agccactctt caatccaaaa tcagtgccgg ttattggtgc atctgacaga aaagaatctg ttggatatgc tgttatgaat aatatgatta aaggaggata taaaggaaat ttatatccag ttggaagaaa accagaactt tttggaaaga aatgttatgc taagattggc aaaattgaag agaaagtaga tcttgcagtt attgctattc cagctaaatt tgtaccaggt gtatgtattg aatgtggtga agctggtgtt aaaggactta ttatcattac tgctggtttt gctgaagctg gagaagaagg aaagaaaatg tgtattgaaa ttcaagcaac ttgccaaaaa tacaacatga gaatgattgg tccaaactgt cttggtatta tcaatccaag agacggagtt aatgcatcat ttgcttcagt tatgccagaa gctggaggag ttgccttcat ttcacaatca ggagcccttt gtactgctat tcttgattgg gctgctaatc aacatgttgg attctcatac tttgtttcaa ttggatcatc aattgatact gattatgctg atctttttga attctttgct aaagatccaa aagtcacttc aattcttatg tacattgaat caattaaaga tgctaagaaa tttgtcttaa gagctcgtga atttgctgct gacaaaccaa ttatcttact taaagctggt aaatcatcag aaggagctgc tgctgctatg tcacatactg gatcacttgc tggaaatgat gcagtttatg atgcagtctt tgatagatgt ggatgtattc gtgtagattc aatttgtgat ctttgggatt gtgctcacgt ccttgctacc caaaatattc cacaaaataa cagactttgc attattacta atgctggagg gcctggtgtt atttcaactg atagacttgt ttcagttcat ggtcatcttg ctaaactttc agaatctact atgaatgaac ttaatgcatt cctttcacca ttctggtcac attctaatcc agttgatgtt cttggtgatg ctactgctgg tgtttaccaa aagactcttg atattgttat taaggatcca caaattgacg gagttgttgt tgtcttaact ccacaagcta tgactgatcc agttgctgtt gctaaatcat tagttgaaca tggaccatat caaaaccagt ccttgcctca tggatgggtc aatcagaagt ccgaagctgg tgtcaagatt cttgaagaag gaaagattcc aaactttgaa acaccagaaa gagctgttac tgcatttggt tatattatga gacatccaga cattgctgct aaattaaagg aaattccaaa atatcttgat gttcaagttg attatgaagg agctaagaaa cttattgctg atgttgttgc tgatggaaga acaaccttca ctgaatatga aggaaagatg atgttctcta aatatggaat tccaattaaa ggtatggcta aagcctcaac tgaagacgaa gcagttgctg aagctatgaa aattggaaca ccagttgtca tgaaaattct ttcaccagat attatgcaca agactgatgt tggaggagtt aaagttaaat taacaactga agaagaaatt agaaaggctt acagagacat tatgacatct gttaaagaaa agaaaccaga agctagaatt catggagttc tccttgaaaa gatggttgga tttaaatatg aatgtatcat tggatgcaag aaagatccat tattcggtcc agtcattgtc tttggtatgg gaggtgttac tgttgaatta tacaaagata ctaatattgc tcttccacca attggattac aagaagctga tagacttatt gatggaacta agatttctaa attattaaga ggatacagag gaatgccagc ttgtgatgtt gaaggactta agaagatcct tgtccaattc tcaaagatga ttatggactt cccagaaatc tcagaagttg atattaatcc acttgctgtc tcttatgaag aattccttgt ccttgatgct aagattgtct tagacaagaa tatgattggt aaggaagtac caaagtactc tcacctcgtc atccaaccat aa

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