LebrA.18809.a: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)
Target Characteristics
| from organism: | Leishmania braziliensis MHOM/BR/75/M2904 |
| most recent status: | selected |
| center reference id: | LebrA.18809.a |
| is community request: | True |
| associated disease: | |
| NIH risk group: | 2 |
| is select agent: | False |
| NIH priority pathogens category: |
unclassified |
Ordering Clones & Proteins
If there are materials available for this target, they will be listed below.
Materials can be ordered from SSGCID using the button in the "order material" column.
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You may order multiple materials at a time at no cost to you, as this contract is funded
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External Resources
| Resource | Reference ID |
|---|---|
| EuPathDB: | TriTrypDB:LBRM_30_3180 |
| UniProt: | A4HIQ3 |
Enzyme & Pathway Information
| Pathway | Pathway ID | EC Number |
|---|---|---|
| superpathway of ergosterol biosynthesis I | ERGOSTEROL-SYN-PWY | 1.1.1.34 |
| superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | PWY-5910 | 1.1.1.34 |
| Methanobacterium thermoautotrophicum biosynthetic metabolism | PWY-6146 | 1.1.1.34 |
| mevalonate pathway II (archaea) | PWY-6174 | 1.1.1.34 |
| superpathway of cholesterol biosynthesis | PWY66-5 | 1.1.1.34 |
| isoprene biosynthesis II (engineered) | PWY-7391 | 1.1.1.34 |
| mevalonate pathway III (archaea) | PWY-7524 | 1.1.1.34 |
| mevalonate pathway I | PWY-922 | 1.1.1.34 |
Sequences
These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols.
To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MRRSILLACS AAKGGNWASM SDAEIMKQVE DKKIAFYGLE QALAPDYDRA IAIRRDIVKK KMCPSSAATH PLERVPYKNY DWGNVVGQNC ENILGYVPVP VGLAGPLLLD GKEVGLPMAT TEGALVASTH RGARAINLSG GCRTAVLKEG MTRAPVVEVS SFDEAIALVK FCEERFDMLK EAFESTTRFG KLQSIKCAMA GRQVHMRFSA FTGDAMGMNM ITKGCDKALR VLQQHIPSMR VLALSGNFCT DKKPSAVNWV EGRGKSVVAE AVIKRCVVEG VLKCTVDSVV SLNVTKNLRG SALAGSIGGF NAHAANIVAA LYIATGQDPA QVVESATCMT TIDKVGEDLM ISLTMPSIEV GAVGGGTGLS SQSAMLELMG CAGANKEDPG ANSRQIARVV AGAVICGELS LMAGLAAGHL LSAHMKLNRK PSSQ
NT Sequence
atgcgtcgct ctatcctgct tgcctgctcc gccgccaagg gggggaactg ggcatccatg tccgatgcag agatcatgaa acaggtggaa gataagaaga ttgcatttta cggtcttgaa caggcacttg cccccgacta cgaccgcgcc atcgccatcc gtcgtgatat tgtcaagaaa aagatgtgcc catcctctgc tgccacacat ccgttggaga gggtgcctta caagaactac gactggggca acgttgtggg ccagaactgc gaaaacattc tcggctatgt tccagtaccg gtgggattgg ctggtccgct gctgttggat ggaaaggagg tgggactacc gatggcgacg acggagggtg cactggtcgc gagtacgcac cgtggcgcgc gtgccatcaa cctgagcggt ggctgccgga cggcagtact gaaggaaggc atgacgcgtg cccccgtagt ggaggtaagc tccttcgacg aggccatcgc cttggtcaag ttctgtgagg agcggttcga catgctaaag gaggccttcg agtcgactac ccgctttgga aagctgcaga gcatcaagtg tgccatggcg ggtcgtcagg tgcatatgcg cttctctgcc tttactgggg atgcgatggg catgaacatg atcacgaagg gctgcgacaa ggcgctgcgg gtgttgcagc agcacattcc ctccatgcgg gtgctggctt tgtcgggtaa cttttgcact gacaagaagc cgtccgcagt gaactgggtg gagggacgcg gaaagtcggt tgtggcggag gccgtcatca agcgttgtgt ggtcgaaggc gttctcaagt gcaccgttga cagcgttgtg tcgctgaatg tgacaaagaa cctgcgcggc tctgcacttg ctgggtccat cggcggtttc aacgcacatg ccgccaacat cgtggccgcg ctctacatcg caactggtca agaccccgcg caggtagtgg agtccgcaac gtgtatgacg acgattgaca aggtgggtga ggatctcatg atcagcctga cgatgccgag catcgaggtt ggcgccgttg gcggtggcac aggcttgtca tcgcagagcg ccatgctgga gctgatgggg tgcgcgggtg ctaacaaaga agacccgggt gccaattccc gccagattgc acgcgtcgtt gcaggcgcag tcatttgcgg ggagctgtcc ctcatggccg gccttgccgc tggtcacttg ctgagtgccc acatgaagct gaatcgaaag ccctcgagtc agtaa