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Seattle Structural Genomics Center for Infectious Disease

LebrA.18809.a: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)

Target Characteristics

from organism: Leishmania braziliensis MHOM/BR/75/M2904
most recent status: selected
center reference id: LebrA.18809.a
is community request: True
associated disease:
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
unclassified

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

External Resources

Resource Reference ID
EuPathDB: TriTrypDB:LBRM_30_3180
UniProt: A4HIQ3

Enzyme & Pathway Information

Pathway Pathway ID EC Number
superpathway of ergosterol biosynthesis I ERGOSTEROL-SYN-PWY 1.1.1.34
superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) PWY-5910 1.1.1.34
Methanobacterium thermoautotrophicum biosynthetic metabolism PWY-6146 1.1.1.34
mevalonate pathway II (archaea) PWY-6174 1.1.1.34
superpathway of cholesterol biosynthesis PWY66-5 1.1.1.34
isoprene biosynthesis II (engineered) PWY-7391 1.1.1.34
mevalonate pathway III (archaea) PWY-7524 1.1.1.34
mevalonate pathway I PWY-922 1.1.1.34

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MRRSILLACS AAKGGNWASM SDAEIMKQVE DKKIAFYGLE QALAPDYDRA IAIRRDIVKK KMCPSSAATH PLERVPYKNY DWGNVVGQNC ENILGYVPVP VGLAGPLLLD GKEVGLPMAT TEGALVASTH RGARAINLSG GCRTAVLKEG MTRAPVVEVS SFDEAIALVK FCEERFDMLK EAFESTTRFG KLQSIKCAMA GRQVHMRFSA FTGDAMGMNM ITKGCDKALR VLQQHIPSMR VLALSGNFCT DKKPSAVNWV EGRGKSVVAE AVIKRCVVEG VLKCTVDSVV SLNVTKNLRG SALAGSIGGF NAHAANIVAA LYIATGQDPA QVVESATCMT TIDKVGEDLM ISLTMPSIEV GAVGGGTGLS SQSAMLELMG CAGANKEDPG ANSRQIARVV AGAVICGELS LMAGLAAGHL LSAHMKLNRK PSSQ

NT Sequence
atgcgtcgct ctatcctgct tgcctgctcc gccgccaagg gggggaactg ggcatccatg tccgatgcag agatcatgaa acaggtggaa gataagaaga ttgcatttta cggtcttgaa caggcacttg cccccgacta cgaccgcgcc atcgccatcc gtcgtgatat tgtcaagaaa aagatgtgcc catcctctgc tgccacacat ccgttggaga gggtgcctta caagaactac gactggggca acgttgtggg ccagaactgc gaaaacattc tcggctatgt tccagtaccg gtgggattgg ctggtccgct gctgttggat ggaaaggagg tgggactacc gatggcgacg acggagggtg cactggtcgc gagtacgcac cgtggcgcgc gtgccatcaa cctgagcggt ggctgccgga cggcagtact gaaggaaggc atgacgcgtg cccccgtagt ggaggtaagc tccttcgacg aggccatcgc cttggtcaag ttctgtgagg agcggttcga catgctaaag gaggccttcg agtcgactac ccgctttgga aagctgcaga gcatcaagtg tgccatggcg ggtcgtcagg tgcatatgcg cttctctgcc tttactgggg atgcgatggg catgaacatg atcacgaagg gctgcgacaa ggcgctgcgg gtgttgcagc agcacattcc ctccatgcgg gtgctggctt tgtcgggtaa cttttgcact gacaagaagc cgtccgcagt gaactgggtg gagggacgcg gaaagtcggt tgtggcggag gccgtcatca agcgttgtgt ggtcgaaggc gttctcaagt gcaccgttga cagcgttgtg tcgctgaatg tgacaaagaa cctgcgcggc tctgcacttg ctgggtccat cggcggtttc aacgcacatg ccgccaacat cgtggccgcg ctctacatcg caactggtca agaccccgcg caggtagtgg agtccgcaac gtgtatgacg acgattgaca aggtgggtga ggatctcatg atcagcctga cgatgccgag catcgaggtt ggcgccgttg gcggtggcac aggcttgtca tcgcagagcg ccatgctgga gctgatgggg tgcgcgggtg ctaacaaaga agacccgggt gccaattccc gccagattgc acgcgtcgtt gcaggcgcag tcatttgcgg ggagctgtcc ctcatggccg gccttgccgc tggtcacttg ctgagtgccc acatgaagct gaatcgaaag ccctcgagtc agtaa

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