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Seattle Structural Genomics Center for Infectious Disease

LedoB.18809.a: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)

Target Characteristics

from organism: Leishmania donovani BPK282A1
most recent status: expressed
center reference id: LedoB.18809.a
is community request: True
associated disease: Leishmaniasis
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
unclassified

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
LedoB.18809.a.B2.GE41119 mature protein; soluble domain 19 398 GE41119
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

External Resources

Resource Reference ID
EuPathDB: TriTrypDB:LDBPK_303230
UniProt: E9BM66

Enzyme & Pathway Information

Pathway Pathway ID EC Number
superpathway of ergosterol biosynthesis I ERGOSTEROL-SYN-PWY 1.1.1.34
superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) PWY-5910 1.1.1.34
Methanobacterium thermoautotrophicum biosynthetic metabolism PWY-6146 1.1.1.34
mevalonate pathway II (archaea) PWY-6174 1.1.1.34
superpathway of cholesterol biosynthesis PWY66-5 1.1.1.34
isoprene biosynthesis II (engineered) PWY-7391 1.1.1.34
mevalonate pathway III (archaea) PWY-7524 1.1.1.34
mevalonate pathway I PWY-922 1.1.1.34

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MRRSLLLACS AAKGGSWASM PDAEIMKQVE NKKIAFYGLE QALAPDYDRA IAIRREIVKK KMCPSTAATH PLERVPYKNY DWSSVVGQSC ENILGYVPVP VGLAGPLLLD GKEVALPMAT TEGALVASAH RGARAINLSG GCRTAVLKEG MTRAPVVEVN SFDEAITVIK FCEERFDVLK EAFESTTRFG KLLSIKCAMA GRQVHMRFSA FTGDAMGMNM ITKGCDKALQ VLQQHIPSVR VLTLSGNFCT DKKPSALNWV EGRGKSVVAE AVIKRDVVEG VLKCTVDSVV SLNVTKNLRG SALAGSIGGF NAHAANIVAA LYIATGQDPA QIVESATCMT TVDKAGEDLV ISLTMPSIEV GAVGGGTGLS SQRAMLELMG CAGSNKEDPG ANSRQIARVV AGAVICGELS LLSGLAAGHL LSAHMKLNRK PPTQ

NT Sequence
atgcgtcgct ctctgctgct tgcctgctcc gccgccaagg gtgggagctg ggcatccatg cccgatgcag agatcatgaa gcaggtggag aataagaaga ttgcatttta cggccttgag caggctcttg cacccgacta tgaccgcgcc atcgccattc gtcgtgagat tgtgaagaaa aagatgtgtc catcaaccgc tgccacacat ccgctggaga gggttcccta caagaactac gactggagca gtgttgtcgg ccagagctgc gagaacatcc tcggctacgt tccggtaccg gtagggttgg ctggcccgct gctgttggat ggaaaggaag tggcactgcc gatggcgacg acggagggtg cgctggtcgc gagtgcgcac cgcggtgctc gcgccatcaa cctgagcggc ggatgccgga cagcggtgct gaaggaaggc atgacgcgcg cccctgtagt ggaggtgaac tctttcgacg aggccatcac cgtgatcaag ttctgtgagg agcggttcga cgttctgaag gaggccttcg agtcgacgac ccgcttcggg aagttgctga gcatcaagtg cgccatggcg ggtcgccagg tgcatatgcg cttctctgcc tttactggag atgcgatggg catgaacatg atcacgaagg gctgtgacaa ggcgctgcag gtgctgcagc agcacattcc ctctgtgcga gtgctgacct tgtcgggcaa cttctgcact gacaagaagc cgtccgcact gaactgggtg gagggacgcg ggaagtcggt cgtggcggag gccgtcatca agcgtgatgt ggtcgagggt gttctcaaat gcacggtgga cagtgttgtg tcgctgaatg tgactaagaa cctgcgcggt tctgcgcttg ccggttccat cggcggcttc aacgcacacg ctgccaacat tgtggccgcg ctctacatcg ccactggcca ggaccccgca cagatagtgg agtccgcaac ctgcatgacg acggttgaca aggctggtga ggatctcgtg atcagcctca cgatgccgag catcgaggtc ggcgccgtag gcggtggcac aggtctgtcg tcgcagcggg ccatgctgga gctgatgggg tgcgcgggct ctaacaagga ggacccaggt gccaactccc gccagatcgc gcgcgtcgtc gctggcgcag tcatttgcgg ggagctgtcc ctcttgtccg gccttgcagc tggccacttg ctgagcgccc acatgaagct gaaccgcaag cctccgactc agtaa

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