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Seattle Structural Genomics Center for Infectious Disease

LemaA.18809.a: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)

Target Characteristics

from organism: Leishmania major Friedlin
most recent status: expressed
center reference id: LemaA.18809.a
is community request: True
associated disease: Cutaneous leishmaniasis
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
unclassified

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
LemaA.18809.a.B2.GE41028 mature protein; soluble domain 19 398 GE41028
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

External Resources

Resource Reference ID
EuPathDB: TriTrypDB:LmjF.30.3190
UniProt: Q9Y0F3

Enzyme & Pathway Information

Pathway Pathway ID EC Number
superpathway of ergosterol biosynthesis I ERGOSTEROL-SYN-PWY 1.1.1.34
superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) PWY-5910 1.1.1.34
Methanobacterium thermoautotrophicum biosynthetic metabolism PWY-6146 1.1.1.34
mevalonate pathway II (archaea) PWY-6174 1.1.1.34
superpathway of cholesterol biosynthesis PWY66-5 1.1.1.34
isoprene biosynthesis II (engineered) PWY-7391 1.1.1.34
mevalonate pathway III (archaea) PWY-7524 1.1.1.34
mevalonate pathway I PWY-922 1.1.1.34

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MRRSLLLACS AAKGESWASM SDTEIMKQVE NKKIAFHGLE QALAPDYDRA IAIRREIVKK KICPSPAATH PLERVPYKNY DWSSVVGQSC ENILGYVPVP VGLAGPLLLD GKEVALPMAT TEGALVASAH RGARAINLSG GCRTAVLKEG MTRAPVVEVN SFDEAITVIK FCEERFDVLR EAFESTTRFG KLLSIKCAMA GRQVHLRFSA FTGDAMGMNM ITKGCDKALQ VLQQHIPSVR VLTLSGNFCT DKKPSALNWV EGRGKSVVAE AVIKRDVVES VLKCTVDSVV SLNVTKNLRG SALAGSIGGF NAHAANIVAA LYIATGQDPA QVVESATCMT TVDKAGEDLV ISLMMPSIEV GAVGGGTGLS SQRAMLELMG CAGSNKEDPG AHSRQIARVV AGAVICGELS LLSGLAAGHL LSAHMKLNRK PPTP

NT Sequence
atgcgccgct ctctgctgct tgcctgctcc gccgccaagg gtgagagctg ggcatccatg tccgatacag agatcatgaa gcaggtggag aataagaaga ttgcatttca cggccttgag caggctcttg cacccgacta tgaccgcgcc atcgccattc gtcgtgagat tgtgaagaaa aagatatgtc catctccagc tgccacacat ccgctggaga gggttcccta caagaactac gactggagca gtgttgtggg acagagctgc gagaacatcc tcggctacgt tccggtaccg gtagggttgg ctggtccgct gctgttggat ggaaaggaag tggcactgcc gatggcgacg acggagggtg cgctggtcgc gagtgcgcac cgcggtgctc gcgccatcaa cctgagcggc ggatgccgga cagcggtgct gaaggaaggc atgacgcgcg cccctgtagt ggaggtgaac tccttcgacg aggccatcac cgtgatcaag ttctgtgagg agcggttcga cgttctaagg gaggccttcg agtcgacgac ccgcttcggg aagttgctga gcatcaagtg tgccatggcg ggtcgccagg tgcatctgcg cttctctgcc tttaccggag atgcgatggg catgaatatg atcacgaagg gctgcgacaa ggcgctgcag gtgctgcagc agcacattcc ctctgtgcga gtgctgacct tgtcaggcaa cttctgcact gacaagaaac cgtccgcact gaactgggtg gagggacgcg ggaagtcggt cgtagcggag gccgtcatca agcgtgatgt ggtcgagagt gttctcaagt gcacggtgga cagtgttgtg tcgctgaatg taactaagaa cctgcgcgga tctgcgcttg ccggttccat cggcggcttc aacgcacacg ctgccaacat cgtggccgcg ctctacatcg ccactggcca ggaccccgca caggtagtgg agtccgcaac ctgcatgacg acggttgaca aggctggtga ggatctcgtg atcagcctca tgatgccgag cattgaggtc ggcgccgtag gcggtggtac aggtctgtcg tcgcagcgcg ccatgctgga gctgatgggg tgcgcgggct ctaacaagga ggacccaggt gcccactccc gccagatcgc gcgtgtcgtt gctggcgcag tcatttgcgg tgagctgtcc ctcttgtccg gccttgcagc tggccactta ctaagcgccc acatgaagct gaaccgcaag cctccgactc cgtaa

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