LemaA.18809.a: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)
Target Characteristics
from organism: | Leishmania major Friedlin |
most recent status: | expressed |
center reference id: | LemaA.18809.a |
is community request: | True |
associated disease: | Cutaneous leishmaniasis |
NIH risk group: | 2 |
is select agent: | False |
NIH priority pathogens category: |
unclassified |
Ordering Clones & Proteins
If there are materials available for this target, they will be listed below.
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Clones*
CENTER REFERENCE ID |
DOMAIN/REGION DESCRIPTION |
INFO | AA START |
AA STOP |
ORDER MATERIAL |
---|---|---|---|---|---|
LemaA.18809.a.B2.GE41028 | mature protein; soluble domain | 19 | 398 | GE41028 |
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information
using the button in the "info" column.
External Resources
Resource | Reference ID |
---|---|
EuPathDB: | TriTrypDB:LmjF.30.3190 |
UniProt: | Q9Y0F3 |
Enzyme & Pathway Information
Pathway | Pathway ID | EC Number |
---|---|---|
superpathway of ergosterol biosynthesis I | ERGOSTEROL-SYN-PWY | 1.1.1.34 |
superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | PWY-5910 | 1.1.1.34 |
Methanobacterium thermoautotrophicum biosynthetic metabolism | PWY-6146 | 1.1.1.34 |
mevalonate pathway II (archaea) | PWY-6174 | 1.1.1.34 |
superpathway of cholesterol biosynthesis | PWY66-5 | 1.1.1.34 |
isoprene biosynthesis II (engineered) | PWY-7391 | 1.1.1.34 |
mevalonate pathway III (archaea) | PWY-7524 | 1.1.1.34 |
mevalonate pathway I | PWY-922 | 1.1.1.34 |
Sequences
These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols.
To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MRRSLLLACS AAKGESWASM SDTEIMKQVE NKKIAFHGLE QALAPDYDRA IAIRREIVKK KICPSPAATH PLERVPYKNY DWSSVVGQSC ENILGYVPVP VGLAGPLLLD GKEVALPMAT TEGALVASAH RGARAINLSG GCRTAVLKEG MTRAPVVEVN SFDEAITVIK FCEERFDVLR EAFESTTRFG KLLSIKCAMA GRQVHLRFSA FTGDAMGMNM ITKGCDKALQ VLQQHIPSVR VLTLSGNFCT DKKPSALNWV EGRGKSVVAE AVIKRDVVES VLKCTVDSVV SLNVTKNLRG SALAGSIGGF NAHAANIVAA LYIATGQDPA QVVESATCMT TVDKAGEDLV ISLMMPSIEV GAVGGGTGLS SQRAMLELMG CAGSNKEDPG AHSRQIARVV AGAVICGELS LLSGLAAGHL LSAHMKLNRK PPTP
NT Sequence
atgcgccgct ctctgctgct tgcctgctcc gccgccaagg gtgagagctg ggcatccatg tccgatacag agatcatgaa gcaggtggag aataagaaga ttgcatttca cggccttgag caggctcttg cacccgacta tgaccgcgcc atcgccattc gtcgtgagat tgtgaagaaa aagatatgtc catctccagc tgccacacat ccgctggaga gggttcccta caagaactac gactggagca gtgttgtggg acagagctgc gagaacatcc tcggctacgt tccggtaccg gtagggttgg ctggtccgct gctgttggat ggaaaggaag tggcactgcc gatggcgacg acggagggtg cgctggtcgc gagtgcgcac cgcggtgctc gcgccatcaa cctgagcggc ggatgccgga cagcggtgct gaaggaaggc atgacgcgcg cccctgtagt ggaggtgaac tccttcgacg aggccatcac cgtgatcaag ttctgtgagg agcggttcga cgttctaagg gaggccttcg agtcgacgac ccgcttcggg aagttgctga gcatcaagtg tgccatggcg ggtcgccagg tgcatctgcg cttctctgcc tttaccggag atgcgatggg catgaatatg atcacgaagg gctgcgacaa ggcgctgcag gtgctgcagc agcacattcc ctctgtgcga gtgctgacct tgtcaggcaa cttctgcact gacaagaaac cgtccgcact gaactgggtg gagggacgcg ggaagtcggt cgtagcggag gccgtcatca agcgtgatgt ggtcgagagt gttctcaagt gcacggtgga cagtgttgtg tcgctgaatg taactaagaa cctgcgcgga tctgcgcttg ccggttccat cggcggcttc aacgcacacg ctgccaacat cgtggccgcg ctctacatcg ccactggcca ggaccccgca caggtagtgg agtccgcaac ctgcatgacg acggttgaca aggctggtga ggatctcgtg atcagcctca tgatgccgag cattgaggtc ggcgccgtag gcggtggtac aggtctgtcg tcgcagcgcg ccatgctgga gctgatgggg tgcgcgggct ctaacaagga ggacccaggt gcccactccc gccagatcgc gcgtgtcgtt gctggcgcag tcatttgcgg tgagctgtcc ctcttgtccg gccttgcagc tggccactta ctaagcgccc acatgaagct gaaccgcaag cctccgactc cgtaa