NIAID Emerging and Re-emerging Infectious Diseases NIAID Bioinformatics Resource Centers NIAID Structural Genomic Centers Center for Structural Genomics of Infectious Disease
Seattle Structural Genomics Center for Infectious Disease

LyepA.19906.a: Envelope glycoprotein H (gH)

Target Characteristics

from organism: Lymphocryptovirus Epstein-Barr virus (Human herpesvirus 4) GD1 (HHV-4)
most recent status: in PDB
center reference id: LyepA.19906.a
is community request: False
associated disease:
NIH risk group: unclassified
is select agent: False
NIH priority
pathogens category:
unclassified

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Structures

image of structure for 6C5V
6C5V
Deposited: 1/16/2018
Determination: CryoEM
Clone: LyepA.19906.a.LM2.GE42469
Protein: LyepA.19906.a.LM2.PE00002

Publications by SSGCID

An antibody targeting the fusion machinery neutralizes dual-tropic infection and defines a site of vulnerability on Epstein-Barr virus
Snijder J, McGuire AT, Veesler D, Ortego MS, Weidle C, Stuart AB, Gray MA, McElrath MJ, Pancera M
Immunity - 2018
PMID: 29669253; PMCID: PMC5909843
PDB: 6BLA, 6C5V

Citations by Others

Gammaherpesvirus entry and fusion: A tale how two human pathogenic viruses enter their host cells
BS Mhl, J Chen, R Longnecker- Adv. Virus Res, 2019 - books.google.com
cited by: 1 other
PDB: 6C5V

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
UniProt: K9US75

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MQLLCVFCLV LLWEVGAASL SEVKLHLDIE GHASHYTIPW TELMAKVPGL SPEALWREAN VTEDLASMLN RYKLIYKTSG TLGIALAEPV DIPAVSEGSM QVDASKVHPG VISGLNSPAC MLSAPLEKQL FYYIGTMLPN TRPHSYVFYQ LRCHLSYVAL SINGDKFQYT GAMTSKFLMG TYKRVTEKGD EHVLSLVFGK TKDLPDLRGP FSYPSLTSAQ SGDYSLVIVT TFVHYANFHN YFVPNLKDMF SRAVTMTAAS YARYVLQKLV LLEMKGGCRE PELDTETLTT MFEVSVAFFK VGHAVGETGN GCVDLRWLAK SFFELTVLKD IIGICYGATV KGMQSYGLER LAAMLMATVK MEELGHLTTE KQEYALRLAT VGYPKAGVYS GLIGGATSVL LSAYNRHPLF QPLHTVMRET LFIGSHVVLR ELRLNVTTQG PNLALYQLLS TALCSALEIG EVLRGLALGT ESGLFSPCYL SLRFDLTRDK LLSMAPQEAT LDQAAVSYAV DGFLGRLSLE REDRDAWHLP AYKCVDRLDK VLMIIPLINV TFIISSDREV RGSALYEAST TYLSSSLFLS PVIMNKCSQG AVAGEPRQIP KIQNFTRTQK SCIFCGFALL SYDEKEGLET TTYITSQEVQ NSILSSNYFD FDNLHVHYLL LTTNGTVMEI AGLYEERAHV VLAIILYFIA FALGIFLVHK IVMFFL

NT Sequence
ATGCAGTTGC TCTGTGTTTT TTGCCTGGTG TTGCTATGGG AGGTGGGGGC TGCCAGCCTC AGCGAGGTTA AGCTGCACCT GGACATAGAG GGGCATGCTT CGCATTACAC CATCCCATGG ACCGAACTGA TGGCAAAGGT CCCAGGCCTT AGCCCAGAGG CGCTGTGGAG AGAGGCAAAT GTCACCGAAG ATTTGGCGTC TATGCTTAAC CGCTACAAGT TAATTTACAA GACGTCTGGT ACCCTTGGTA TTGCGCTGGC CGAGCCTGTC GATATCCCTG CTGTCTCTGA AGGATCCATG CAAGTGGATG CATCTAAGGT CCATCCCGGA GTCATTAGCG GCCTGAATTC CCCTGCCTGC ATGCTTAGTG CCCCCCTTGA GAAGCAGCTC TTCTACTATA TTGGCACCAT GCTGCCCAAC ACGCGGCCAC ACAGCTATGT CTTTTATCAG CTGCGCTGTC ACTTGTCTTA TGTGGCCCTG TCCATCAACG GGGACAAGTT TCAGTACACG GGGGCCATGA CTTCTAAATT TCTGATGGGC ACCTACAAGC GAGTGACCGA GAAGGGAGAT GAGCATGTGT TGAGCCTGGT CTTTGGCAAG ACGAAGGACC TGCCGGATCT GAGGGGGCCT TTTAGTTACC CATCCTTAAC CAGTGCCCAA AGCGGGGACT ATTCCCTGGT GATTGTTACA ACCTTTGTGC ATTATGCCAA CTTTCACAAC TACTTTGTAC CCAACCTGAA GGATATGTTT TCCCGAGCCG TCACCATGAC AGCCGCCAGC TACGCTCGCT ACGTTCTCCA GAAACTGGTC CTGCTGGAGA TGAAGGGAGG CTGCCGGGAG CCGGAACTGG ACACGGAAAC GCTGACTACC ATGTTTGAGG TTTCTGTGGC CTTCTTTAAG GTGGGTCATG CTGTGGGTGA GACTGGCAAT GGCTGCGTGG ACCTCCGCTG GTTGGCCAAG AGCTTCTTTG AGCTGACTGT CCTGAAAGAC ATCATCGGCA TATGTTATGG GGCCACTGTC AAGGGCATGC AATCCTACGG GCTGGAGCGC TTGGCCGCCA TGCTGATGGC CACGGTCAAA ATGGAGGAGC TGGGTCACCT AACTACTGAG AAACAGGAGT ACGCGCTGAG GTTAGCCACC GTCGGCTACC CCAAGGCCGG GGTTTACAGT GGCCTCATTG GAGGCGCCAC ATCTGTGCTT CTCTCGGCCT ACAACCGCCA CCCCCTTTTC CAGCCCCTGC ATACCGTGAT GAGAGAGACC CTGTTTATCG GCAGCCACGT GGTGCTACGC GAGTTGCGGC TGAACGTGAC TACCCAGGGG CCCAACCTTG CCCTATACCA ACTGCTGTCC ACCGCCCTGT GCTCGGCCCT AGAGATTGGG GAGGTTTTGC GGGGGCTAGC CCTGGGGACA GAGAGCGGGC TCTTCTCACC GTGCTACCTC AGCCTACGAT TTGACCTCAC ACGAGACAAG CTGCTGAGCA TGGCCCCCCA GGAGGCAACG CTGGACCAGG CGGCCGTTTC ATATGCTGTG GATGGGTTTC TTGGGCGGCT CTCTTTGGAG CGAGAAGACA GGGATGCGTG GCATCTCCCC GCCTACAAAT GCGTGGACAG GCTCGACAAA GTTCTGATGA TTATCCCGCT CATCAATGTG ACATTCATAA TCTCTAGTGA CCGTGAGGTC CGAGGCTCGG CGCTATACGA GGCCAGCACC ACCTATCTCA GCAGCTCTCT CTTTCTCTCC CCCGTTATAA TGAATAAATG TTCGCAGGGT GCTGTGGCTG GGGAGCCCCG CCAGATTCCA AAGATCCAGA ATTTTACCAG GACGCAGAAA TCCTGCATTT TTTGTGGCTT TGCCCTGCTC AGTTATGATG AAAAGGAAGG CCTGGAAACT ACAACCTACA TCACCTCCCA GGAAGTCCAA AACTCCATTT TGAGCTCCAA CTACTTTGAT TTTGACAACC TCCACGTTCA CTATCTGCTG CTGACCACCA ACGGGACTGT CATGGAAATT GCGGGCCTGT ATGAAGAAAG AGCACACGTT GTTTTGGCAA TAATCCTGTA CTTTATTGCT TTTGCTCTGG GTATCTTTCT GGTTCACAAG ATTGTTATGT TTTTCCTT

© 2020 Seattle Children's Research Institute. All rights reserved.