MyabA.00725.a: Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE)
Target Characteristics
| from organism: | Mycobacterium abscessus ATCC 19977 / DSM 44196 |
| most recent status: | in PDB |
| center reference id: | MyabA.00725.a |
| is community request: | True |
| associated disease: | Skin abscess |
| NIH risk group: | 2 |
| is select agent: | False |
| NIH priority pathogens category: |
IIIC |
Ordering Clones & Proteins
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Clones*
| CENTER REFERENCE ID |
DOMAIN/REGION DESCRIPTION |
INFO | AA START |
AA STOP |
ORDER MATERIAL |
|---|---|---|---|---|---|
| MyabA.00725.a.A1.GE30336 | Full length( MyabA.00725.a ) | 1 | 314 | GE30336 |
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information
using the button in the "info" column.
Proteins
| CENTER REFERENCE ID |
DOMAIN/REGION DESCRIPTION |
INFO | AA START |
AA STOP |
ORDER MATERIAL |
|---|---|---|---|---|---|
| MyabA.00725.a.A1.PW30213 | Full length( MyabA.00725.a ) | 1 | 314 |
Structures
4DXL
Deposited: 2/27/2012
Determination: XRay
Diffraction Image
Clone: MyabA.00725.a.A1.GE30336
Protein: MyabA.00725.a.A1.PW30213
4ED4
Deposited: 3/26/2012
Determination: XRay
Diffraction Image
Clone: MyabA.00725.a.A1.GE30336
Protein: MyabA.00725.a.A1.PW30213
4EMD
Deposited: 4/11/2012
Determination: XRay
Diffraction Image
Clone: MyabA.00725.a.A1.GE30336
Protein: MyabA.00725.a.A1.PW30213
Publications by SSGCID
Increasing the structural coverage of tuberculosis drug targets.
Abendroth J, Abramov A, Armour B, Barrett LK, Baugh L, Begley DW, Buchko GW, Choi R, Clifton MC, Dieterich SH, Dranow DM, Edwards TE, Fairman JW, Ferrell M, Fox D, Gardberg AS, Hewitt SN, Lorimer D, Lyons-Abbott S, Mundt E, Muruthi MM, Myers J, Myler PJ, Napuli AJ, Phan I, Sekar A, Serbzhinskiy D, Stacy R, Staker BL, Stewart LJ, Taylor BM, Thompkins K, Tran N, Van Voorhis WC, Zhang Y
Tuberculosis (Edinb) - 2014
volume 95, issue 2, pages 142-8
PMID: 25613812; PMCID: PMC4361283
PDB:
3GVC,
3GVG,
3GWC,
3H7F,
3H81,
3HE2,
3HWI,
3HWK,
3HZG,
3ICO,
3KHP,
3LLS,
3MOY,
3MPZ,
3MYB,
3NDN,
3NDO,
3NF4,
3NG3,
3NJD,
3NWO,
3O0M,
3O38,
3OC6,
3OC7,
3OEC,
3OI9,
3OKS,
3OL3,
3OL4,
3OME,
3P0T,
3P2Y,
3P4I,
3P4T,
3P5M,
3P85,
3PE8,
3PGX,
3PK0,
3PPI,
3PXX,
3PZY,
3Q1T,
3Q8N,
3QBP,
3QDF,
3QH4,
3QHA,
3QIV,
3QK8,
3QKA,
3QLJ,
3QMJ,
3QRE,
3QUA,
3QUV,
3QXI,
3QXZ,
3QYR,
3R0O,
3R1I,
3R1J,
3R20,
3R2N,
3R4T,
3R6H,
3R6O,
3R7K,
3R8C,
3R9P,
3R9Q,
3R9R,
3R9S,
3R9T,
3RD5,
3RD7,
3RD8,
3RFQ,
3RIH,
3RR2,
3RR6,
3RRP,
3RRV,
3RSI,
3RV2,
3S55,
3S82,
3SBX,
3SF6,
3SLL,
3SVK,
3SVT,
3SWO,
3SWT,
3SWX,
3SX2,
3T3W,
3T7C,
3TAV,
3TCR,
3TDE,
3TJR,
3TL3,
3TLF,
3TRR,
3TSC,
3TX2,
3TZQ,
3TZU,
3U0A,
3U0B,
3UCX,
3UVE,
4DI1,
4DIE,
4DQ8,
4DXL,
4ED4,
4EGE,
4EGF,
4EMD,
4EO9,
4EYE,
4F3W,
4F47,
4FFC,
4GK6,
4HDT,
4HR3,
4I1Y,
4IJN,
4IV6,
4IZ9,
4J5I,
4KAM,
4LGV,
4O2D,
5EJ2
Citations by Others
| Oxadiazole and phenol derivatives as antibacterial and/or herbicidal agents | |
| TJ Hagen, M Thompson, JR Troxell- US Patent App. 15, 2018 - Google Patents | |
| PDB: 4DXL |
| Evaluation of IspE for inhibitor design in the non-mevalonate pathway | |
| KB Hoerchler - 2018 - commons.lib.niu.edu | |
| PDB: 4DXL, 4ED4, 4EMD |
| Molecular Recognition in Chemical and Biological Systems | |
| E Persch, O Dumele, F Diederich - … Chemie International Edition, 2015 - Wiley Online Library | |
| cited by: | 148 others |
| PDB: 4DXL, 4ED4, 4EMD | |
| Molekulare Erkennung in chemischen und biologischen Systemen | |
| E Persch, O Dumele, F Diederich - Angewandte Chemie, 2015 - Wiley Online Library | |
| cited by: | 21 others |
| PDB: 4DXL, 4ED4, 4EMD | |
| Extraction of Protein Binding Pockets in Close Neighborhood of Bound Ligands Makes Comparisons Simple Due to Inherent Shape Similarity | |
| T Krotzky, T Rickmeyer, T Fober… - Journal of chemical …, 2014 - ACS Publications | |
| cited by: | 8 others |
| PDB: 4ED4 | |
| PROTEIN-LIGAND INTERACTIONS AND STRUCTURE-BASED INHIBITOR DISCOVERY | |
| S Usha, S Selvaraj - 2018 - 14.139.186.108 | |
| PDB: 4EMD |
This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.
External Resources
| Resource | Reference ID |
|---|---|
| OrthoMCL: | OG5_130885 |
| PATRIC ID: | fig|36809.5.peg.1175 |
| RefSeq: | YP_001701881.1 |
| UniProt: | B1MKD5 |
Enzyme & Pathway Information
| Pathway | Pathway ID | EC Number |
|---|---|---|
| methylerythritol phosphate pathway I | NONMEVIPP-PWY | 2.7.1.148 |
| superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) | PWY-5121 | 2.7.1.148 |
| isoprene biosynthesis I | PWY-6270 | 2.7.1.148 |
| superpathway of ergosterol biosynthesis II | PWY-7156 | 2.7.1.148 |
| taxadiene biosynthesis (engineered) | PWY-7392 | 2.7.1.148 |
| methylerythritol phosphate pathway II | PWY-7560 | 2.7.1.148 |
Sequences
These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols.
To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MSETVSDWVP TGAVTVRAPG KVNLYLAVGD LRDDGYHELT TVFHAVSLAD DVTVRDADVL SIDVVGQGEG TVPTDERNLA WQAAELFADH VGRAPDVSIF INKDIPVAGG MAGGSADAAA VLVAMNELWH AGVPRRDLHH LAAQLGSDVP FALHGGTALG TGRGEQLATV LARNVFHWVF AFADGGLATP QVFKEIDRLR ENGDPPRLAE ADELLGALAA GDARRLAPLL GNELQAAAVS LNPELRRTLR AGESAGALAG IVSGSGPTCA FLCTSADDAV QVSAELAGAG VCRTVRVASG PVHGAQVIQG RSDG
NT Sequence
GTGTCCGAGA CCGTCTCCGA TTGGGTTCCT ACCGGCGCGG TGACTGTCCG GGCACCCGGC AAGGTCAATC TGTACCTGGC CGTAGGTGAC CTCCGTGACG ACGGCTATCA CGAGCTGACC ACGGTTTTTC ACGCCGTTTC GCTGGCCGAC GACGTGACCG TGCGGGACGC CGACGTGTTA TCGATCGATG TGGTCGGGCA GGGCGAGGGC ACGGTGCCCA CCGACGAACG CAATCTCGCC TGGCAGGCCG CCGAGCTTTT CGCCGATCAC GTGGGCCGCG CCCCCGACGT CTCGATCTTC ATTAACAAGG ACATCCCCGT CGCGGGCGGT ATGGCCGGCG GATCCGCCGA TGCCGCTGCG GTGTTGGTGG CGATGAACGA GCTCTGGCAT GCCGGTGTGC CGCGCCGGGA CCTGCACCAC CTGGCCGCTC AACTGGGCAG CGATGTCCCC TTTGCCTTAC ATGGCGGCAC CGCGCTGGGC ACTGGCCGGG GTGAGCAGCT GGCGACCGTA TTGGCGCGCA ATGTCTTTCA TTGGGTGTTC GCCTTCGCCG ACGGGGGACT GGCGACGCCT CAGGTCTTCA AGGAGATCGA CCGGTTGCGT GAGAACGGCG ATCCGCCGCG GCTCGCCGAG GCGGATGAGC TTTTGGGTGC GCTCGCCGCC GGGGACGCGC GCCGGCTGGC GCCGCTGCTC GGTAACGAAT TGCAGGCCGC GGCGGTCAGC CTGAACCCCG AATTGCGGCG CACGCTGCGG GCAGGGGAGT CGGCCGGCGC CCTGGCTGGA ATCGTCTCCG GATCGGGCCC CACCTGTGCG TTCTTGTGCA CCTCGGCCGA CGATGCGGTG CAGGTGAGTG CGGAGCTGGC GGGCGCGGGG GTGTGCCGCA CCGTGCGGGT GGCCAGCGGA CCCGTGCACG GCGCACAGGT CATCCAGGGC CGCAGTGACG GC