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Seattle Structural Genomics Center for Infectious Disease

MyabA.01026.b: 4-aminobutyrate aminotransferase (GabT)

Target Characteristics

from organism: Mycobacterium abscessus ATCC 19977 / DSM 44196
most recent status: in PDB
center reference id: MyabA.01026.b
is community request: False
associated disease: Skin abscess
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MyabA.01026.b.A1.GE30384 Full length( MyabA.01026.b ) 1 449 GE30384
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MyabA.01026.b.A1.PS00899 Full length( MyabA.01026.b ) 1 449

Structures

image of structure for 4FFC
4FFC
Deposited: 5/31/2012
Determination: XRay
Diffraction Image
Clone: MyabA.01026.b.A1.GE30384
Protein: MyabA.01026.b.A1.PS00899

Publications by SSGCID

Increasing the structural coverage of tuberculosis drug targets.
Abendroth J, Abramov A, Armour B, Barrett LK, Baugh L, Begley DW, Buchko GW, Choi R, Clifton MC, Dieterich SH, Dranow DM, Edwards TE, Fairman JW, Ferrell M, Fox D, Gardberg AS, Hewitt SN, Lorimer D, Lyons-Abbott S, Mundt E, Muruthi MM, Myers J, Myler PJ, Napuli AJ, Phan I, Sekar A, Serbzhinskiy D, Stacy R, Staker BL, Stewart LJ, Taylor BM, Thompkins K, Tran N, Van Voorhis WC, Zhang Y
Tuberculosis (Edinb) - 2014
volume 95, issue 2, pages 142-8
PMID: 25613812; PMCID: PMC4361283
PDB: 3GVC, 3GVG, 3GWC, 3H7F, 3H81, 3HE2, 3HWI, 3HWK, 3HZG, 3ICO, 3KHP, 3LLS, 3MOY, 3MPZ, 3MYB, 3NDN, 3NDO, 3NF4, 3NG3, 3NJD, 3NWO, 3O0M, 3O38, 3OC6, 3OC7, 3OEC, 3OI9, 3OKS, 3OL3, 3OL4, 3OME, 3P0T, 3P2Y, 3P4I, 3P4T, 3P5M, 3P85, 3PE8, 3PGX, 3PK0, 3PPI, 3PXX, 3PZY, 3Q1T, 3Q8N, 3QBP, 3QDF, 3QH4, 3QHA, 3QIV, 3QK8, 3QKA, 3QLJ, 3QMJ, 3QRE, 3QUA, 3QUV, 3QXI, 3QXZ, 3QYR, 3R0O, 3R1I, 3R1J, 3R20, 3R2N, 3R4T, 3R6H, 3R6O, 3R7K, 3R8C, 3R9P, 3R9Q, 3R9R, 3R9S, 3R9T, 3RD5, 3RD7, 3RD8, 3RFQ, 3RIH, 3RR2, 3RR6, 3RRP, 3RRV, 3RSI, 3RV2, 3S55, 3S82, 3SBX, 3SF6, 3SLL, 3SVK, 3SVT, 3SWO, 3SWT, 3SWX, 3SX2, 3T3W, 3T7C, 3TAV, 3TCR, 3TDE, 3TJR, 3TL3, 3TLF, 3TRR, 3TSC, 3TX2, 3TZQ, 3TZU, 3U0A, 3U0B, 3UCX, 3UVE, 4DI1, 4DIE, 4DQ8, 4DXL, 4ED4, 4EGE, 4EGF, 4EMD, 4EO9, 4EYE, 4F3W, 4F47, 4FFC, 4GK6, 4HDT, 4HR3, 4I1Y, 4IJN, 4IV6, 4IZ9, 4J5I, 4KAM, 4LGV, 4O2D, 5EJ2

Citations by Others

Crystal structure of -aminobutyrate aminotransferase in complex with a PLP-GABA adduct from Corynebacterium glutamicum
J Hong, KJ Kim- Biochemical and biophysical research communications, 2019 - Elsevier
cited by: 1 other
PDB: 4FFC
Polyamines in fungi
J Ruiz-Herrera - 2016 - 5.63.15.51
PDB: 4FFC

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_128761
PATRIC ID: fig|36809.5.peg.4285
RefSeq: YP_001704934.1
UniProt: B1MIQ9

Enzyme & Pathway Information

Pathway Pathway ID EC Number
superpathway of 4-aminobutanoate degradation 4AMINOBUTMETAB-PWY 2.6.1.19
superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation ARGDEG-PWY 2.6.1.19
beta-alanine degradation I BETA-ALA-DEGRADATION-I-PWY 2.6.1.19
GABA shunt GLUDEG-I-PWY 2.6.1.19
superpathway of L-arginine and L-ornithine degradation ORNARGDEG-PWY 2.6.1.19
nicotine degradation I (pyridine pathway) P181-PWY 2.6.1.19
glutamate degradation IX (via 4-aminobutyrate) PWY3O-210 2.6.1.19
L-glutamate degradation IV PWY-4321 2.6.1.19
4-aminobutanoate degradation V PWY-5022 2.6.1.19
4-aminobutanoate degradation I PWY-6535 2.6.1.19
4-aminobutanoate degradation III PWY-6536 2.6.1.19
4-aminobutanoate degradation II PWY-6537 2.6.1.19
L-valine degradation I VALDEG-PWY 2.6.1.22

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MTDITYRLAQ KRTIVTPLPG PRSGALAERR RAAVSAGVGS TAPVYAVDAD GGVIVDADGN SFIDLGAGIA VTTVGASHPA VAAAIADQAT HFTHTCFMVT PYEGYVQVAE LLNALTPGDH DKRTALFNSG AEAVENAIKV ARLATGRPAV VAFDNAYHGR TNLTMALTAK SMPYKSQFGP FAPEVYRMPA SYPLRDEPGL TGEEAARRAI SRIETQIGAQ SLAAIIIEPI QGEGGFIVPA PGFLATLTAW ASENGVVFIA DEVQTGFART GAWFASEHEG IVPDIVTMAK GIAGGMPLSA VTGRAELMDA VYAGGLGGTY GGNPVTCAAA VAALGVMREL DLPARARAIE ASVTSRLSAL AEEVDIIGEV RGRGAMLAIE IVKPGTLEPD AALTKSIAAE ALSQGVLILT CGTFGNVIRL LPPLVIGDDL LDEGITALSD IIRAKASHQ

NT Sequence
ATGACCGACA TCACCTATCG CCTCGCCCAG AAGCGCACCA TCGTGACGCC GCTACCGGGA CCCCGGTCCG GTGCACTGGC CGAGCGCCGC CGCGCCGCGG TGTCGGCGGG TGTGGGCTCC ACCGCGCCGG TCTATGCCGT CGACGCCGAT GGCGGCGTGA TCGTCGACGC CGACGGCAAC TCCTTCATCG ACCTCGGAGC AGGCATCGCG GTGACCACCG TCGGCGCCTC CCACCCGGCC GTTGCCGCCG CAATCGCCGA CCAGGCAACC CATTTCACTC ATACCTGTTT CATGGTGACG CCCTACGAGG GGTACGTACA GGTCGCCGAG CTGCTCAACG CCCTGACCCC CGGCGATCAT GACAAGCGCA CCGCACTGTT CAACTCGGGT GCCGAGGCCG TCGAGAACGC CATCAAGGTG GCACGGCTGG CCACCGGGCG ACCCGCCGTG GTCGCATTCG ACAACGCCTA TCACGGACGC ACCAACCTGA CCATGGCACT GACCGCCAAG TCGATGCCGT ACAAGTCGCA GTTCGGGCCC TTCGCGCCCG AGGTCTACCG GATGCCCGCC TCCTACCCGT TGCGCGACGA GCCGGGGCTG ACCGGCGAGG AAGCCGCACG GCGGGCGATC TCCCGCATCG AGACCCAGAT CGGCGCGCAG TCACTGGCCG CCATCATCAT CGAACCCATC CAGGGTGAGG GCGGATTCAT CGTGCCCGCA CCGGGATTCC TCGCCACGCT TACCGCATGG GCCAGCGAAA ACGGCGTCGT CTTCATTGCC GACGAAGTGC AGACCGGATT CGCCCGTACC GGCGCGTGGT TTGCCTCCGA GCACGAGGGC ATCGTCCCGG ACATCGTCAC CATGGCCAAG GGCATCGCCG GCGGTATGCC GCTGTCGGCC GTCACCGGGC GCGCCGAGCT GATGGACGCC GTGTACGCCG GCGGCCTCGG CGGCACCTAT GGCGGCAATC CGGTGACCTG CGCGGCCGCC GTCGCCGCGC TGGGGGTCAT GCGTGAACTC GATCTGCCCG CACGTGCGCG AGCCATCGAA GCCTCGGTGA CGTCCCGGCT GAGTGCACTC GCCGAAGAGG TGGACATCAT CGGCGAGGTA CGCGGGCGCG GCGCCATGCT GGCCATCGAG ATCGTCAAAC CAGGAACGCT GGAACCCGAT GCCGCCCTCA CCAAATCCAT TGCCGCCGAA GCGCTCTCCC AGGGCGTGCT GATCCTCACC TGCGGAACCT TCGGCAACGT CATCCGCTTG CTGCCACCGC TGGTTATCGG GGACGATCTA CTCGACGAGG GCATCACCGC CCTCTCCGAC ATCATTCGTG CGAAGGCGAG CCACCAG

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