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Seattle Structural Genomics Center for Infectious Disease

MyavA.00640.a: Acetate kinase

Target Characteristics

from organism: Mycobacterium avium 104
most recent status: in PDB
center reference id: MyavA.00640.a
is community request: False
associated disease: Johne's disease, paratuberculosis
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MyavA.00640.a.A1.GE28563 Full length( MyavA.00640.a ) 1 387 GE28563
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Structures

image of structure for 3P4I
3P4I
Deposited: 10/6/2010
Determination: XRay
Diffraction Image
Clone: MyavA.00640.a.A1.GE28563
Protein: MyavA.00640.a.A1.PS00663
image of structure for 4IZ9
4IZ9
Deposited: 1/29/2013
Determination: XRay
Diffraction Image
Clone: MyavA.00640.a.A1.GE28563
Protein: MyavA.00640.a.A1.PS00663

Publications by SSGCID

Increasing the structural coverage of tuberculosis drug targets.
Abendroth J, Abramov A, Armour B, Barrett LK, Baugh L, Begley DW, Buchko GW, Choi R, Clifton MC, Dieterich SH, Dranow DM, Edwards TE, Fairman JW, Ferrell M, Fox D, Gardberg AS, Hewitt SN, Lorimer D, Lyons-Abbott S, Mundt E, Muruthi MM, Myers J, Myler PJ, Napuli AJ, Phan I, Sekar A, Serbzhinskiy D, Stacy R, Staker BL, Stewart LJ, Taylor BM, Thompkins K, Tran N, Van Voorhis WC, Zhang Y
Tuberculosis (Edinb) - 2014
volume 95, issue 2, pages 142-8
PMID: 25613812; PMCID: PMC4361283
PDB: 3GVC, 3GVG, 3GWC, 3H7F, 3H81, 3HE2, 3HWI, 3HWK, 3HZG, 3ICO, 3KHP, 3LLS, 3MOY, 3MPZ, 3MYB, 3NDN, 3NDO, 3NF4, 3NG3, 3NJD, 3NWO, 3O0M, 3O38, 3OC6, 3OC7, 3OEC, 3OI9, 3OKS, 3OL3, 3OL4, 3OME, 3P0T, 3P2Y, 3P4I, 3P4T, 3P5M, 3P85, 3PE8, 3PGX, 3PK0, 3PPI, 3PXX, 3PZY, 3Q1T, 3Q8N, 3QBP, 3QDF, 3QH4, 3QHA, 3QIV, 3QK8, 3QKA, 3QLJ, 3QMJ, 3QRE, 3QUA, 3QUV, 3QXI, 3QXZ, 3QYR, 3R0O, 3R1I, 3R1J, 3R20, 3R2N, 3R4T, 3R6H, 3R6O, 3R7K, 3R8C, 3R9P, 3R9Q, 3R9R, 3R9S, 3R9T, 3RD5, 3RD7, 3RD8, 3RFQ, 3RIH, 3RR2, 3RR6, 3RRP, 3RRV, 3RSI, 3RV2, 3S55, 3S82, 3SBX, 3SF6, 3SLL, 3SVK, 3SVT, 3SWO, 3SWT, 3SWX, 3SX2, 3T3W, 3T7C, 3TAV, 3TCR, 3TDE, 3TJR, 3TL3, 3TLF, 3TRR, 3TSC, 3TX2, 3TZQ, 3TZU, 3U0A, 3U0B, 3UCX, 3UVE, 4DI1, 4DIE, 4DQ8, 4DXL, 4ED4, 4EGE, 4EGF, 4EMD, 4EO9, 4EYE, 4F3W, 4F47, 4FFC, 4GK6, 4HDT, 4HR3, 4I1Y, 4IJN, 4IV6, 4IZ9, 4J5I, 4KAM, 4LGV, 4O2D, 5EJ2

Citations by Others

Investigation of pyrophosphate versus ATP substrate selection in the Entamoeba histolytica acetate kinase
T Dang, C Ingram-Smith- Scientific Reports, 2017 - ncbi.nlm.nih.gov
PDB: 3P4I
Significant reduction in errors associated with nonbonded contacts in protein crystal structures: automated all-atom refinement with PrimeX
JA Bell, KL Ho, R Farid - Acta Crystallographica Section D: Biological Crystallography, 2012 - scripts.iucr.org
cited by: 10 others
PDB: 3P4I
Mechanistic features of< i> Salmonella typhimurium propionate kinase (TdcD): Insights from kinetic and crystallographic studies
S Chittori, DK Simanshu, S Banerjee? - Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013 - Elsevier
cited by: 2 others
PDB: 4IZ9

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_130287
PATRIC ID: fig|243243.7.peg.4678
RefSeq: YP_883886.1
UniProt: A0QLU8

Enzyme & Pathway Information

Pathway Pathway ID EC Number
(S)-propane-1,2-diol degradation PWY-7013 2.7.2.1
superpathway of L-threonine metabolism THREOCAT-PWY 2.7.2.1

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MDGSDGARRV LVINSGSSSL KFQLVDPESG VAASTGIVER IGEESSPVPD HDAALRRAFD MLAGDGVDLN TAGLVAVGHR VVHGGNTFYR PTVLDDAVIA RLHELSELAP LHNPPALLGI EVARRLLPGI AHVAVFDTGF FHDLPPAAAT YAIDRELADR WQIRRYGFHG TSHRYVSEQA AAFLDRPLRG LKQIVLHLGN GCSASAIAGT RPLDTSMGLT PLEGLVMGTR SGDIDPSVVS YLCHTAGMGV DDVESMLNHR SGVVGLSGVR DFRRLRELIE SGDGAAQLAY SVFTHRLRKY IGAYLAVLGH TDVISFTAGI GENDAAVRRD AVSGMEELGI VLDERRNLPG AKGARQISAD DSPITVLVVP TNEELAIARD CVRVLGG

NT Sequence
GTGGACGGTA GCGACGGCGC GCGCCGGGTG CTGGTGATCA ACTCCGGCTC GTCGTCGCTG AAGTTCCAGC TGGTCGATCC CGAGTCCGGG GTGGCCGCCT CGACGGGCAT CGTGGAACGC ATCGGCGAGG AATCCTCGCC GGTCCCCGAC CACGACGCCG CGCTGCGCCG AGCGTTCGAC ATGCTGGCCG GCGACGGCGT CGACCTGAAC ACCGCCGGGC TGGTCGCGGT GGGTCATCGG GTGGTGCACG GCGGCAACAC CTTCTACCGG CCCACCGTGC TGGACGACGC GGTGATCGCC CGGCTGCACG AGCTGTCGGA GTTGGCCCCG CTGCACAATC CGCCGGCGCT CCTGGGGATC GAAGTGGCCC GCAGGCTGCT GCCCGGCATC GCGCACGTGG CCGTCTTCGA CACCGGGTTC TTCCACGACC TGCCGCCCGC GGCGGCGACC TACGCCATCG ACCGCGAACT GGCCGACCGC TGGCAGATCC GCCGGTACGG GTTCCACGGC ACCTCGCACC GCTACGTCAG CGAGCAGGCC GCGGCTTTCC TGGATCGGCC GCTGCGCGGC CTGAAACAGA TCGTGCTGCA CCTGGGCAAC GGCTGCTCGG CGTCAGCGAT CGCCGGCACC CGGCCCCTCG ACACCTCGAT GGGGTTGACG CCGCTGGAGG GACTGGTGAT GGGTACCCGC AGCGGTGACA TCGATCCCAG CGTCGTCAGC TATCTGTGCC ACACGGCCGG GATGGGGGTG GACGACGTCG AGTCGATGCT CAACCACCGC TCGGGGGTGG TCGGGCTGTC CGGCGTGCGG GACTTCCGCC GGCTGCGCGA ACTCATCGAA TCCGGGGACG GCGCAGCGCA ATTGGCCTAC AGCGTGTTCA CGCACCGGCT GCGCAAGTAC ATCGGTGCCT ACCTGGCGGT GCTGGGCCAC ACCGACGTCA TCAGCTTCAC CGCCGGCATC GGTGAGAACG ACGCCGCGGT GCGCCGCGAC GCGGTGTCGG GCATGGAGGA GCTGGGCATT GTGCTCGACG AGCGCCGCAA CCTGCCCGGG GCCAAAGGGG CACGCCAGAT CTCGGCCGAC GACTCGCCGA TCACGGTGCT GGTGGTCCCC ACCAACGAAG AGCTGGCCAT CGCCCGTGAC TGCGTGCGGG TGCTAGGCGG A

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