NIAID Emerging and Re-emerging Infectious Diseases NIAID Bioinformatics Resource Centers NIAID Structural Genomic Centers Center for Structural Genomics of Infectious Disease
Seattle Structural Genomics Center for Infectious Disease

MyavA.01625.a: S-adenosylmethionine synthetase

Target Characteristics

from organism: Mycobacterium avium 104
most recent status: in PDB
center reference id: MyavA.01625.a
is community request: False
associated disease: Johne's disease, paratuberculosis
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MyavA.01625.a.A1.GE29156 Full length( MyavA.01625.a ) 1 403 GE29156
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Structures

image of structure for 3S82
3S82
Deposited: 5/27/2011
Determination: XRay
Diffraction Image
Clone: MyavA.01625.a.A1.GE29156
Protein: MyavA.01625.a.A1.PS00723

Publications by SSGCID

Increasing the structural coverage of tuberculosis drug targets.
Abendroth J, Abramov A, Armour B, Barrett LK, Baugh L, Begley DW, Buchko GW, Choi R, Clifton MC, Dieterich SH, Dranow DM, Edwards TE, Fairman JW, Ferrell M, Fox D, Gardberg AS, Hewitt SN, Lorimer D, Lyons-Abbott S, Mundt E, Muruthi MM, Myers J, Myler PJ, Napuli AJ, Phan I, Sekar A, Serbzhinskiy D, Stacy R, Staker BL, Stewart LJ, Taylor BM, Thompkins K, Tran N, Van Voorhis WC, Zhang Y
Tuberculosis (Edinb) - 2014
volume 95, issue 2, pages 142-8
PMID: 25613812; PMCID: PMC4361283
PDB: 3GVC, 3GVG, 3GWC, 3H7F, 3H81, 3HE2, 3HWI, 3HWK, 3HZG, 3ICO, 3KHP, 3LLS, 3MOY, 3MPZ, 3MYB, 3NDN, 3NDO, 3NF4, 3NG3, 3NJD, 3NWO, 3O0M, 3O38, 3OC6, 3OC7, 3OEC, 3OI9, 3OKS, 3OL3, 3OL4, 3OME, 3P0T, 3P2Y, 3P4I, 3P4T, 3P5M, 3P85, 3PE8, 3PGX, 3PK0, 3PPI, 3PXX, 3PZY, 3Q1T, 3Q8N, 3QBP, 3QDF, 3QH4, 3QHA, 3QIV, 3QK8, 3QKA, 3QLJ, 3QMJ, 3QRE, 3QUA, 3QUV, 3QXI, 3QXZ, 3QYR, 3R0O, 3R1I, 3R1J, 3R20, 3R2N, 3R4T, 3R6H, 3R6O, 3R7K, 3R8C, 3R9P, 3R9Q, 3R9R, 3R9S, 3R9T, 3RD5, 3RD7, 3RD8, 3RFQ, 3RIH, 3RR2, 3RR6, 3RRP, 3RRV, 3RSI, 3RV2, 3S55, 3S82, 3SBX, 3SF6, 3SLL, 3SVK, 3SVT, 3SWO, 3SWT, 3SWX, 3SX2, 3T3W, 3T7C, 3TAV, 3TCR, 3TDE, 3TJR, 3TL3, 3TLF, 3TRR, 3TSC, 3TX2, 3TZQ, 3TZU, 3U0A, 3U0B, 3UCX, 3UVE, 4DI1, 4DIE, 4DQ8, 4DXL, 4ED4, 4EGE, 4EGF, 4EMD, 4EO9, 4EYE, 4F3W, 4F47, 4FFC, 4GK6, 4HDT, 4HR3, 4I1Y, 4IJN, 4IV6, 4IZ9, 4J5I, 4KAM, 4LGV, 4O2D, 5EJ2

Citations by Others

Synthesis of non-natural cofactor analogs of S-adenosyl-L-methionine using methionine adenosyltransferase
J Thorson, T Huber, J Zhang, S Singh- US Patent 9,879,043, 2018 - freepatentsonline.com
PDB: 3S82

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_126734
PATRIC ID: fig|243243.7.peg.3311
RefSeq: YP_882564.1
UniProt: A0QI26

Enzyme & Pathway Information

Pathway Pathway ID EC Number
ethylene biosynthesis I (plants) ETHYL-PWY 2.5.1.6
L-methionine degradation I (to L-homocysteine) METHIONINE-DEG1-PWY 2.5.1.6
superpathway of S-adenosyl-L-methionine biosynthesis MET-SAM-PWY 2.5.1.6
aspartate superpathway PWY0-781 2.5.1.6
S-adenosyl-L-methionine cycle II PWY-5041 2.5.1.6
superpathway of L-methionine salvage and degradation PWY-5328 2.5.1.6
2'-deoxymugineic acid phytosiderophore biosynthesis PWY-5912 2.5.1.6
S-adenosyl-L-methionine cycle I PWY-6151 2.5.1.6
superpathway of L-cysteine biosynthesis (mammalian) PWY-6292 2.5.1.6
L-methionine salvage cycle II (plants) PWY-7270 2.5.1.6
L-methionine salvage cycle III PWY-7527 2.5.1.6
L-methionine salvage cycle I (bacteria and plants) PWY-7528 2.5.1.6
L-cysteine biosynthesis VI (from L-methionine) PWY-I9 2.5.1.6
S-adenosyl-L-methionine biosynthesis SAM-PWY 2.5.1.6

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MSEKGRLFTS ESVTEGHPDK ICDAISDSVL DALLAQDPRS RVAVETLVTT GQVHVVGEVT TTAKEAFADI TNTVRERILD IGYDSSDKGF DGASCGVNIG IGAQSPDIAQ GVDTAHETRV EGAADPLDAQ GAGDQGLMFG YAINDTPERM PLPIALAHRL SRRLTEVRKN GVLPYLRPDG KTQVTIEFED DVPVRLDTVV ISTQHAADID LENTLTPDIR EKVLNTVLND LAHDTLDTSS TRLLVNPTGK FVVGGPMGDA GLTGRKIIVD TYGGWARHGG GAFSGKDPSK VDRSAAYAMR WVAKNIVAAG LAERVEVQVA YAIGKAAPVG LFIETFGTAT VDPVKIEKIV PEVFDLRPGA IIRDLDLLRP IYAQTAAYGH FGRTDVELPW EQLNKVDDLK RAI

NT Sequence
ATGAGCGAAA AGGGTCGCCT GTTTACCAGT GAGTCGGTGA CTGAGGGACA TCCCGACAAG ATCTGTGACG CGATCAGCGA CTCGGTCCTC GACGCCCTGC TGGCGCAGGA CCCCCGCTCA CGTGTCGCGG TCGAGACCCT GGTGACCACC GGGCAGGTGC ACGTGGTCGG CGAGGTGACG ACGACGGCCA AGGAGGCCTT CGCCGACATC ACCAACACGG TCCGCGAGCG CATCCTCGAC ATCGGCTACG ACTCGTCGGA CAAGGGCTTC GACGGGGCGT CCTGCGGGGT CAACATCGGC ATCGGCGCGC AGTCGCCCGA CATCGCCCAG GGCGTCGACA CCGCCCACGA GACCCGCGTC GAGGGTGCCG CCGACCCGCT GGACGCGCAG GGCGCCGGCG ACCAGGGCCT GATGTTCGGC TACGCGATCA ACGACACCCC CGAGCGGATG CCGCTGCCCA TCGCGCTGGC CCACCGCCTG TCGCGCCGGC TGACGGAGGT CCGCAAGAAC GGCGTGCTGC CCTACCTGCG CCCCGACGGC AAGACGCAGG TGACCATCGA ATTCGAGGAC GACGTCCCGG TCCGGCTGGA CACCGTGGTC ATCTCCACTC AGCACGCGGC CGACATCGAC CTGGAGAACA CCCTGACCCC CGACATCCGG GAAAAGGTGC TCAACACCGT GCTCAACGAC CTGGCGCACG ACACGCTGGA CACCTCCTCG ACGCGGCTGC TGGTCAACCC GACCGGCAAG TTCGTCGTCG GCGGCCCGAT GGGTGACGCC GGGCTGACCG GGCGCAAGAT CATCGTCGAC ACCTACGGCG GCTGGGCGCG GCACGGCGGC GGGGCGTTCT CCGGCAAGGA CCCGTCCAAG GTGGACCGCT CGGCGGCGTA CGCGATGCGC TGGGTGGCCA AGAACATCGT CGCCGCCGGG CTCGCGGAGC GGGTCGAGGT GCAGGTGGCC TACGCCATCG GCAAGGCCGC GCCGGTCGGG CTGTTCATCG AGACCTTCGG GACCGCGACC GTCGACCCGG TCAAGATCGA GAAGATCGTC CCGGAGGTGT TCGACCTGCG TCCCGGCGCG ATCATCCGCG ACCTGGACCT GCTGCGCCCG ATCTACGCGC AGACCGCCGC CTACGGGCAC TTCGGCCGCA CCGACGTCGA ACTGCCCTGG GAGCAGCTGA ACAAGGTCGA CGACCTCAAG CGCGCCATC

© 2022 Seattle Children's Research Institute. All rights reserved.