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Seattle Structural Genomics Center for Infectious Disease

MyleA.00725.a: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE)

Target Characteristics

from organism: Mycobacterium leprae Br4923
most recent status: selected
center reference id: MyleA.00725.a
is community request: True
associated disease: Hansen's disease, leprosy
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

External Resources

Resource Reference ID
OrthoMCL: OG5_130885
PATRIC ID: fig|561304.4.peg.372
RefSeq: YP_002502932.1
UniProt: B8ZU60

Enzyme & Pathway Information

Pathway Pathway ID EC Number
methylerythritol phosphate pathway I NONMEVIPP-PWY 2.7.1.148
superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) PWY-5121 2.7.1.148
isoprene biosynthesis I PWY-6270 2.7.1.148
superpathway of ergosterol biosynthesis II PWY-7156 2.7.1.148
taxadiene biosynthesis (engineered) PWY-7392 2.7.1.148
methylerythritol phosphate pathway II PWY-7560 2.7.1.148

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MPTGSVTVQV PGKINLYLAV GDCCDNGYHE LVTVFHAVSL VDQVTVRNAD VLSLGLVGEG ANHVPTDEHN IAWRAAELMA EHVGRAPDVS IMIDKSIPVA GGMAGGSADA AAVLVAMNSL WELSLPRRDL CMLAAKLGSD VPFALHGGTA LGTGRGEELA TVLSRATFHW VLAFADSSLL TPAVYTEFDR LRDVGNPPRL AEPGPVLAAL VAADPEQLAP LLGNELQAAA VSLDPALRCA LRAGMEAGAL AGIVSGSGPT CAFLCASATS AIDVGAQLAG AGVCRTVRVA TGPVPGARVV HAPMSRGLND M

NT Sequence
ATGCCCACCG GGTCGGTCAC CGTTCAGGTT CCCGGGAAGA TCAATCTCTA CCTCGCTGTC GGTGATTGCT GCGATAATGG CTACCACGAG CTGGTGACGG TTTTCCATGC TGTGTCGCTG GTCGACCAGG TTACGGTGCG CAACGCCGAC GTGCTGTCGC TCGGACTTGT CGGCGAGGGC GCCAACCACG TGCCCACTGA CGAACACAAC ATTGCCTGGC GGGCGGCCGA GCTAATGGCC GAGCACGTTG GCCGGGCTCC GGACGTTTCG ATCATGATTG ACAAGTCCAT TCCGGTGGCT GGGGGGATGG CGGGCGGCAG CGCCGATGCG GCCGCGGTGT TGGTTGCGAT GAACTCGTTG TGGGAACTCA GCCTGCCTCG ACGCGATCTG TGCATGCTCG CAGCGAAGCT AGGCAGCGAC GTGCCGTTCG CACTACACGG TGGTACCGCG CTGGGGACCG GTCGCGGTGA GGAGCTAGCT ACCGTGTTGT CCCGCGCCAC TTTCCACTGG GTGTTGGCGT TCGCCGACAG CAGTTTGCTC ACTCCGGCGG TGTACACCGA GTTTGACCGG CTCAGGGATG TCGGAAATCC ACCACGGCTT GCCGAACCCG GGCCGGTGTT GGCCGCCCTG GTCGCCGCCG ATCCCGAACA GTTGGCGCCG TTGCTAGGCA ATGAATTGCA AGCGGCCGCG GTCAGCTTGG ACCCGGCGCT ACGGTGTGCG CTCCGCGCCG GTATGGAAGC GGGTGCGCTC GCGGGCATTG TGTCTGGCTC GGGTCCTACC TGCGCATTCC TGTGTGCCTC GGCGACTTCG GCGATCGATG TCGGTGCGCA GTTGGCAGGG GCGGGTGTCT GTCGCACTGT TCGGGTCGCC ACCGGACCAG TACCCGGTGC TCGGGTGGTA CATGCGCCCA TGAGCCGAGG TCTGAATGAC ATG

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