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Seattle Structural Genomics Center for Infectious Disease

MyleA.01212.a: Malate dehydrogenase

Target Characteristics

from organism: Mycobacterium leprae Br4923
most recent status: soluble
center reference id: MyleA.01212.a
is community request: False
associated disease: Hansen's disease, leprosy
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MyleA.01212.a.A1.GE34933 Full length( MyleA.01212.a ) 1 329 GE34933
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

External Resources

Resource Reference ID
OrthoMCL: OG5_127410
PATRIC ID: fig|561304.4.peg.1954
RefSeq: YP_002503429.1
UniProt: A0A0H3MQD5

Enzyme & Pathway Information

Pathway Pathway ID EC Number
respiration (anaerobic) ANARESP1-PWY 1.1.1.37
mixed acid fermentation FERMENTATION-PWY 1.1.1.37
gluconeogenesis I GLUCONEO-PWY 1.1.1.37
superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass GLYCOLYSIS-TCA-GLYOX-BYPASS 1.1.1.37
glyoxylate cycle GLYOXYLATE-BYPASS 1.1.1.37
L-aspartate degradation II MALATE-ASPARTATE-SHUTTLE-PWY 1.1.1.37
TCA cycle IV (2-oxoglutarate decarboxylase) P105-PWY 1.1.1.37
pyruvate fermentation to propanoate I P108-PWY 1.1.1.37
reductive TCA cycle I P23-PWY 1.1.1.37
incomplete reductive TCA cycle P42-PWY 1.1.1.37
formaldehyde assimilation I (serine pathway) PWY-1622 1.1.1.37
L-carnitine degradation III PWY-3641 1.1.1.37
L-glutamate degradation VIII (to propanoate) PWY-5088 1.1.1.37
reductive TCA cycle II PWY-5392 1.1.1.37
superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle PWY-5464 1.1.1.37
superpathway of glyoxylate cycle and fatty acid degradation PWY-561 1.1.1.37
TCA cycle II (plants and fungi) PWY-5690 1.1.1.37
partial TCA cycle (obligate autotrophs) PWY-5913 1.1.1.37
Methanobacterium thermoautotrophicum biosynthetic metabolism PWY-6146 1.1.1.37
TCA cycle III (animals) PWY66-398 1.1.1.37
gluconeogenesis III PWY66-399 1.1.1.37
methylaspartate cycle PWY-6728 1.1.1.37
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase) PWY-6969 1.1.1.37
malate-oxaloacetate shuttle I PWY-7047 1.1.1.37
malate-oxaloacetate shuttle II PWY-7048 1.1.1.37
C4 photosynthetic carbon assimilation cycle, NAD-ME type PWY-7115 1.1.1.37
chitin degradation to ethanol PWY-7118 1.1.1.37
anaerobic energy metabolism (invertebrates, cytosol) PWY-7383 1.1.1.37
anaerobic energy metabolism (invertebrates, mitochondrial) PWY-7384 1.1.1.37
superpathway of anaerobic energy metabolism (invertebrates) PWY-7389 1.1.1.37
TCA cycle I (prokaryotic) TCA 1.1.1.37
superpathway of glyoxylate bypass and TCA TCA-GLYOX-BYPASS 1.1.1.37

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MSPRPLKVAV TGAAGQIGYS LLFRLASGSL LGLDRPIELR LLEIEPALKA LEGVVMELDD CAFLLLAGVE IGADPNKVFD GVNLALLVGA RPRGPGMERG DLLEANGAIF TAQGKALNAV AAADIRVGVT GNPANTNALI AMTNAPDIPR ERFSALTRLD HNRAIAQLAT KTGSAVTDIR KMTIWGNHSA TQYPDVFHAE IGGKNAAEVV GDQAWIEDYF IPTVAKRGAA IIDARGASSA ASAASATIDA ARDWLLGTPE GNWVSMAVVS DGSYGVPEGL ISSFPVTTTD GDWTIVRGLG IDDFSRGRID KSTAELADER MAVKQLGLI

NT Sequence
GTGAGCCCAC GTCCCCTCAA GGTCGCCGTA ACCGGCGCTG CCGGTCAGAT CGGTTATAGC CTGCTGTTCC GCTTGGCGAG CGGCTCACTG CTGGGGCTTG ACCGCCCGAT TGAGTTGCGT CTGCTTGAGA TTGAGCCCGC GCTCAAGGCG CTCGAGGGTG TCGTGATGGA ACTTGATGAC TGCGCGTTCC TGCTGTTGGC GGGCGTCGAG ATAGGCGCGG ATCCGAACAA GGTCTTCGAC GGTGTCAACC TGGCCCTGCT TGTCGGTGCC CGGCCGCGCG GGCCGGGCAT GGAACGTGGC GATTTATTGG AGGCTAACGG CGCGATATTC ACTGCGCAGG GCAAGGCCCT CAACGCCGTC GCCGCCGCTG ACATCCGTGT CGGTGTGACT GGCAATCCGG CCAACACCAA CGCGCTGATC GCGATGACCA ACGCGCCCGA CATCCCCCGC GAGCGGTTCT CGGCACTTAC CCGTCTGGAC CACAACCGGG CTATTGCGCA GCTAGCCACG AAGACCGGCT CCGCAGTCAC CGACATCAGG AAGATGACGA TCTGGGGCAA CCACTCGGCC ACCCAATACC CCGACGTTTT CCACGCTGAG ATCGGCGGTA AGAACGCGGC CGAGGTCGTG GGGGACCAAG CTTGGATCGA GGACTACTTT ATCCCGACCG TCGCCAAGCG CGGTGCTGCG ATCATCGATG CACGCGGCGC TTCGTCAGCC GCTTCGGCAG CATCGGCGAC CATTGATGCC GCCCGGGACT GGCTGCTGGG CACCCCTGAG GGCAACTGGG TTTCGATGGC GGTGGTATCC GATGGTTCGT ACGGTGTGCC GGAGGGCCTG ATCTCTTCGT TCCCTGTAAC CACCACGGAT GGAGACTGGA CGATCGTCAG GGGCTTGGGG ATCGATGACT TCTCCCGCGG GCGGATCGAC AAGTCGACCG CAGAGCTGGC CGACGAGCGT ATGGCGGTCA AGCAGCTCGG TCTGATT

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