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Seattle Structural Genomics Center for Infectious Disease

MymaA.01026.b: 4-aminobutyrate aminotransferase GabT

Target Characteristics

from organism: Mycobacterium marinum ATCC BAA-535 / M
most recent status: in PDB
center reference id: MymaA.01026.b
is community request: False
associated disease: Cutaneous ulcerations, deep abscesses
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MymaA.01026.b.A1.GE30096 Full length( MymaA.01026.b ) 1 446 GE30096
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MymaA.01026.b.A1.PW29968 Full length( MymaA.01026.b ) 1 446

Structures

image of structure for 3R4T
3R4T
Deposited: 3/17/2011
Determination: XRay
Diffraction Image
Clone: MymaA.01026.b.A1.GE30096
Protein: MymaA.01026.b.A1.PW29968

Publications by SSGCID

Increasing the structural coverage of tuberculosis drug targets.
Abendroth J, Abramov A, Armour B, Barrett LK, Baugh L, Begley DW, Buchko GW, Choi R, Clifton MC, Dieterich SH, Dranow DM, Edwards TE, Fairman JW, Ferrell M, Fox D, Gardberg AS, Hewitt SN, Lorimer D, Lyons-Abbott S, Mundt E, Muruthi MM, Myers J, Myler PJ, Napuli AJ, Phan I, Sekar A, Serbzhinskiy D, Stacy R, Staker BL, Stewart LJ, Taylor BM, Thompkins K, Tran N, Van Voorhis WC, Zhang Y
Tuberculosis (Edinb) - 2014
volume 95, issue 2, pages 142-8
PMID: 25613812; PMCID: PMC4361283
PDB: 3GVC, 3GVG, 3GWC, 3H7F, 3H81, 3HE2, 3HWI, 3HWK, 3HZG, 3ICO, 3KHP, 3LLS, 3MOY, 3MPZ, 3MYB, 3NDN, 3NDO, 3NF4, 3NG3, 3NJD, 3NWO, 3O0M, 3O38, 3OC6, 3OC7, 3OEC, 3OI9, 3OKS, 3OL3, 3OL4, 3OME, 3P0T, 3P2Y, 3P4I, 3P4T, 3P5M, 3P85, 3PE8, 3PGX, 3PK0, 3PPI, 3PXX, 3PZY, 3Q1T, 3Q8N, 3QBP, 3QDF, 3QH4, 3QHA, 3QIV, 3QK8, 3QKA, 3QLJ, 3QMJ, 3QRE, 3QUA, 3QUV, 3QXI, 3QXZ, 3QYR, 3R0O, 3R1I, 3R1J, 3R20, 3R2N, 3R4T, 3R6H, 3R6O, 3R7K, 3R8C, 3R9P, 3R9Q, 3R9R, 3R9S, 3R9T, 3RD5, 3RD7, 3RD8, 3RFQ, 3RIH, 3RR2, 3RR6, 3RRP, 3RRV, 3RSI, 3RV2, 3S55, 3S82, 3SBX, 3SF6, 3SLL, 3SVK, 3SVT, 3SWO, 3SWT, 3SWX, 3SX2, 3T3W, 3T7C, 3TAV, 3TCR, 3TDE, 3TJR, 3TL3, 3TLF, 3TRR, 3TSC, 3TX2, 3TZQ, 3TZU, 3U0A, 3U0B, 3UCX, 3UVE, 4DI1, 4DIE, 4DQ8, 4DXL, 4ED4, 4EGE, 4EGF, 4EMD, 4EO9, 4EYE, 4F3W, 4F47, 4FFC, 4GK6, 4HDT, 4HR3, 4I1Y, 4IJN, 4IV6, 4IZ9, 4J5I, 4KAM, 4LGV, 4O2D, 5EJ2

Citations by Others

Modeling and Docking Study of GABA-AT Protein in Mycobacterium Tuberculosis-A Computational Approach
R Sriroopreddy, P Raghuraman- Research Journal of, 2018 - search.proquest.com
cited by: 1 other
PDB: 3R4T
Structures of a gamma-aminobutyrate (GABA) transaminase from the s-triazine-degrading organism Arthrobacter aurescens TC1 in complex with PLP and with its external aldimine PLP-GABA adduct
H Bruce, A Nguyen Tuan? - Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2012 - scripts.iucr.org
cited by: 1 other
PDB: 3R4T

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_128761
PATRIC ID: fig|216594.6.peg.2262
RefSeq: YP_001850423.1
UniProt: B2HN70

Enzyme & Pathway Information

Pathway Pathway ID EC Number
superpathway of 4-aminobutanoate degradation 4AMINOBUTMETAB-PWY 2.6.1.19
superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation ARGDEG-PWY 2.6.1.19
beta-alanine degradation I BETA-ALA-DEGRADATION-I-PWY 2.6.1.19
GABA shunt GLUDEG-I-PWY 2.6.1.19
superpathway of L-arginine and L-ornithine degradation ORNARGDEG-PWY 2.6.1.19
nicotine degradation I (pyridine pathway) P181-PWY 2.6.1.19
glutamate degradation IX (via 4-aminobutyrate) PWY3O-210 2.6.1.19
L-glutamate degradation IV PWY-4321 2.6.1.19
4-aminobutanoate degradation V PWY-5022 2.6.1.19
4-aminobutanoate degradation I PWY-6535 2.6.1.19
4-aminobutanoate degradation III PWY-6536 2.6.1.19
4-aminobutanoate degradation II PWY-6537 2.6.1.19
L-valine degradation I VALDEG-PWY 2.6.1.22
L-lysine degradation III LYSDEGII-PWY 2.6.1.48
superpathway of L-lysine degradation PWY-5327 2.6.1.48

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MASLDQSRLL VTEIPGPASL ELNKRRAAAV SGGVGVTLPV FVVRAGGGIV EDADGNRLID LGSGIAVTTI GNSAPRVVDA VRDQVEQFTH TCFMVTPYEQ YVAVAEQLNR ITPGSGEKRT VLFNSGAEAV ENSIKVARAH TRKQAVVAFD YAYHGRTNLT MALTAKSMPY KSGFGPFAPE IYRAPVSYPY RDNLLDKDIA TDGELAAERA INLIDKQIGA ANLAAVIIEP IAGEGGFIVP ADGFLPALQR WCRDNDVVFI ADEVQTGFAR TGAMFACDHE NVEPDLIVTA KGIADGFPLS AVTGRAEIMD APHTSGLGGT FGGNPVACAA ALATIETIER DGMVERARQI ERLVMDRLLR LQAADDRLGD VRGRGAMIAM ELVKSGTAEP DAALTQKLAA AAHAAGVIVL TCGMFGNVIR LLPPLTISDE LLSEGLDILC QILADL

NT Sequence
GTGGCCAGCC TCGATCAAAG TCGTCTCTTG GTCACCGAAA TCCCCGGCCC CGCGTCGTTG GAGCTCAACA AGCGCCGGGC CGCGGCGGTG TCGGGTGGCG TCGGGGTCAC CCTGCCGGTG TTCGTGGTTC GCGCGGGTGG CGGAATCGTG GAGGACGCCG ACGGCAACCG GCTGATCGAC CTCGGCTCCG GCATCGCCGT CACGACTATC GGCAATTCGG CGCCCCGCGT GGTGGACGCG GTACGGGACC AGGTGGAGCA GTTCACCCAC ACCTGCTTCA TGGTGACCCC CTACGAGCAA TACGTGGCCG TCGCCGAACA GCTCAATCGG ATCACCCCGG GCTCCGGCGA GAAGCGGACG GTGCTGTTCA ACTCCGGCGC CGAGGCGGTG GAGAACTCCA TCAAGGTCGC CCGCGCGCAC ACCCGTAAGC AGGCCGTGGT CGCGTTCGAC TACGCCTACC ACGGCCGCAC CAACCTGACG ATGGCGCTGA CCGCCAAGTC CATGCCGTAC AAGAGCGGCT TCGGCCCCTT TGCGCCGGAG ATCTACCGCG CACCGGTGTC CTACCCCTAC CGGGACAACC TGCTCGACAA AGACATCGCC ACCGACGGTG AGCTTGCCGC CGAACGCGCC ATCAACCTCA TCGACAAGCA GATCGGCGCC GCCAACCTGG CCGCGGTCAT CATCGAACCG ATCGCGGGCG AGGGCGGCTT CATCGTTCCG GCCGACGGTT TCCTGCCCGC GCTGCAGCGG TGGTGCCGCG ACAACGACGT GGTGTTCATC GCCGACGAGG TGCAGACCGG ATTTGCCCGC ACCGGCGCCA TGTTCGCGTG CGACCACGAG AACGTCGAGC CCGACCTGAT CGTCACCGCC AAAGGCATCG CCGACGGATT CCCCTTGTCG GCGGTCACCG GCCGGGCCGA GATCATGGAC GCCCCGCACA CCAGCGGCTT GGGCGGCACC TTCGGCGGCA ACCCGGTCGC GTGTGCGGCG GCCCTGGCCA CCATCGAAAC GATCGAACGC GACGGCATGG TCGAACGGGC CCGCCAGATC GAACGACTGG TGATGGACCG ATTACTGCGC CTGCAAGCCG CCGATGACCG TCTCGGCGAT GTGCGCGGCC GCGGCGCCAT GATCGCCATG GAGCTGGTGA AATCGGGCAC TGCCGAACCC GACGCTGCGC TCACCCAAAA GCTGGCCGCC GCCGCCCATG CCGCCGGCGT AATTGTCTTG ACGTGCGGAA TGTTCGGCAA CGTGATCCGG CTGCTGCCAC CACTGACGAT CAGCGACGAG CTGCTGTCCG AAGGCCTCGA CATCCTGTGC CAGATCCTGG CCGACCTC

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