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Seattle Structural Genomics Center for Infectious Disease

MymaA.01156.a: O-acetylhomoserine sulfhydrylase MetC

Target Characteristics

from organism: Mycobacterium marinum ATCC BAA-535 / M
most recent status: in PDB
center reference id: MymaA.01156.a
is community request: False
associated disease: Cutaneous ulcerations, deep abscesses
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MymaA.01156.a.A1.GE30145 Full length( MymaA.01156.a ) 1 449 GE30145
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MymaA.01156.a.A1.PS00936 Full length( MymaA.01156.a ) 1 449

Structures

image of structure for 4KAM
4KAM
Deposited: 4/22/2013
Determination: XRay
Diffraction Image
Clone: MymaA.01156.a.A1.GE30145
Protein: MymaA.01156.a.A1.PS00936

Publications by SSGCID

Increasing the structural coverage of tuberculosis drug targets.
Abendroth J, Abramov A, Armour B, Barrett LK, Baugh L, Begley DW, Buchko GW, Choi R, Clifton MC, Dieterich SH, Dranow DM, Edwards TE, Fairman JW, Ferrell M, Fox D, Gardberg AS, Hewitt SN, Lorimer D, Lyons-Abbott S, Mundt E, Muruthi MM, Myers J, Myler PJ, Napuli AJ, Phan I, Sekar A, Serbzhinskiy D, Stacy R, Staker BL, Stewart LJ, Taylor BM, Thompkins K, Tran N, Van Voorhis WC, Zhang Y
Tuberculosis (Edinb) - 2014
volume 95, issue 2, pages 142-8
PMID: 25613812; PMCID: PMC4361283
PDB: 3GVC, 3GVG, 3GWC, 3H7F, 3H81, 3HE2, 3HWI, 3HWK, 3HZG, 3ICO, 3KHP, 3LLS, 3MOY, 3MPZ, 3MYB, 3NDN, 3NDO, 3NF4, 3NG3, 3NJD, 3NWO, 3O0M, 3O38, 3OC6, 3OC7, 3OEC, 3OI9, 3OKS, 3OL3, 3OL4, 3OME, 3P0T, 3P2Y, 3P4I, 3P4T, 3P5M, 3P85, 3PE8, 3PGX, 3PK0, 3PPI, 3PXX, 3PZY, 3Q1T, 3Q8N, 3QBP, 3QDF, 3QH4, 3QHA, 3QIV, 3QK8, 3QKA, 3QLJ, 3QMJ, 3QRE, 3QUA, 3QUV, 3QXI, 3QXZ, 3QYR, 3R0O, 3R1I, 3R1J, 3R20, 3R2N, 3R4T, 3R6H, 3R6O, 3R7K, 3R8C, 3R9P, 3R9Q, 3R9R, 3R9S, 3R9T, 3RD5, 3RD7, 3RD8, 3RFQ, 3RIH, 3RR2, 3RR6, 3RRP, 3RRV, 3RSI, 3RV2, 3S55, 3S82, 3SBX, 3SF6, 3SLL, 3SVK, 3SVT, 3SWO, 3SWT, 3SWX, 3SX2, 3T3W, 3T7C, 3TAV, 3TCR, 3TDE, 3TJR, 3TL3, 3TLF, 3TRR, 3TSC, 3TX2, 3TZQ, 3TZU, 3U0A, 3U0B, 3UCX, 3UVE, 4DI1, 4DIE, 4DQ8, 4DXL, 4ED4, 4EGE, 4EGF, 4EMD, 4EO9, 4EYE, 4F3W, 4F47, 4FFC, 4GK6, 4HDT, 4HR3, 4I1Y, 4IJN, 4IV6, 4IZ9, 4J5I, 4KAM, 4LGV, 4O2D, 5EJ2

Citations by Others

Adaptive laboratory evolution enhances methanol tolerance and conversion in engineered Corynebacterium glutamicum
Y Wang, L Fan, P Tuyishime, J Liu, K Zhang- Communications, 2020 - nature.com
cited by: 7 others
PDB: 4KAM
Impact of Binding Site Comparisons on Medicinal Chemistry and Rational Molecular Design
C Ehrt, T Brinkjost, O Koch - Journal of medicinal chemistry, 2016 - ACS Publications
cited by: 14 others
PDB: 4KAM

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_130839
PATRIC ID: fig|216594.6.peg.1265
RefSeq: YP_001849498.1
UniProt: B2HDS7

Enzyme & Pathway Information

Pathway Pathway ID EC Number
L-methionine biosynthesis III HSERMETANA-PWY 2.5.1.49
L-homocysteine biosynthesis PWY-5344 2.5.1.49
superpathway of L-methionine biosynthesis (by sulfhydrylation) PWY-5345 2.5.1.49
superpathway of L-cysteine biosynthesis (fungi) PWY-6293 2.5.1.49
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II PWY-7174 2.5.1.49
superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) PWY-821 2.5.1.49

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MSAENTSTDA DPTAHWSFET KQIHAGQQPD SATNARALPI YQTTSYTFEN TAHAAALFGL EVPGNIYTRL GNPTTDVVEQ RIAALEGGVA ALFLSSGQAA ETFAILNLAG AGDHIVSSPR LYGGTYNLFH YSLAKLGIEV SFVDDPDNLD SWQAAVRPNT KAFFGETISN PQIDLLDTPG VAEVAHRNGI PLIVDNTIAT PYLIRPFTQG ADIVVHSATK YLGGHGAAIA GVIVDGGTFD WTQGRFPEFT TPDPSYHGVV FAELGAPAYA LKARVQLLRD LGSAASPFNA FLVAQGLETL SLRIERHVSN AQRVAEFLAD REDVVTVNYA GLPGSPWHER AKKLSPKGTG AVLSFELAGG VEAGKAFVNA LKLHSHVANI GDVRSLVIHP ASTTHAQLSP AEQLSTGVSP GLVRLAVGIE GIEDILADLE LGFAAARKFS GDSQAVAAI

NT Sequence
ATGAGCGCCG AAAACACCAG CACTGACGCA GATCCGACCG CGCATTGGTC ATTTGAAACC AAGCAGATCC ACGCTGGCCA GCAGCCCGAT TCCGCCACCA ACGCGCGGGC GCTGCCGATC TACCAAACCA CCTCGTACAC CTTCGAAAAC ACGGCGCACG CTGCCGCTTT GTTCGGCCTG GAGGTTCCCG GCAACATCTA CACGCGGCTG GGCAACCCCA CTACCGATGT GGTCGAGCAG CGCATCGCCG CGCTCGAAGG TGGGGTCGCC GCGCTGTTCC TGTCCTCCGG TCAGGCCGCG GAAACCTTCG CCATCCTCAA CCTGGCCGGC GCGGGCGATC ACATCGTGTC CAGCCCCCGC CTCTACGGCG GCACCTACAA CCTGTTCCAT TACTCGCTAG CAAAGCTGGG GATCGAGGTC AGCTTCGTCG ACGACCCCGA CAACCTGGAC TCGTGGCAGG CGGCGGTGCG GCCCAACACC AAGGCGTTTT TTGGTGAGAC CATCTCCAAC CCGCAGATCG ACCTGCTCGA CACCCCCGGG GTTGCTGAAG TCGCCCACCG CAACGGGATA CCGCTGATCG TCGACAACAC CATCGCCACG CCGTACCTGA TTCGGCCGTT CACGCAGGGC GCCGACATCG TCGTGCACTC GGCCACCAAG TACCTGGGCG GGCACGGCGC CGCGATCGCG GGTGTGATCG TCGATGGCGG CACATTCGAC TGGACGCAGG GCCGTTTTCC CGAATTCACC ACACCGGACC CCAGCTACCA CGGCGTGGTG TTTGCCGAGT TGGGCGCGCC GGCCTATGCC CTCAAGGCAC GCGTCCAGCT GCTGCGCGAC TTGGGGTCGG CGGCCTCGCC GTTCAACGCC TTCCTGGTGG CCCAGGGCCT GGAAACCCTG AGCCTGCGGA TCGAACGGCA CGTTTCCAAC GCGCAGCGCG TCGCAGAGTT CCTGGCCGAC CGCGAGGACG TCGTCACGGT CAACTACGCC GGACTACCCG GTTCGCCGTG GCATGAGCGG GCAAAGAAGC TGTCCCCCAA GGGAACCGGG GCGGTGCTGT CGTTCGAGTT GGCCGGCGGC GTCGAGGCCG GTAAAGCATT CGTGAATGCG CTCAAACTGC ACAGCCACGT CGCCAACATC GGCGATGTGC GCTCGCTGGT GATCCATCCG GCATCGACCA CCCACGCCCA GCTGAGCCCG GCCGAGCAGC TGTCCACCGG CGTCAGTCCG GGACTGGTGC GTTTAGCAGT GGGCATCGAG GGTATAGAAG ACATCCTGGC CGACCTGGAG CTCGGGTTCG CCGCGGCACG CAAGTTCAGC GGCGATTCAC AGGCAGTAGC AGCCATC

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