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Seattle Structural Genomics Center for Infectious Disease

MymaA.01625.a: S-adenosylmethionine synthetase

Target Characteristics

from organism: Mycobacterium marinum ATCC BAA-535 / M
most recent status: in PDB
center reference id: MymaA.01625.a
is community request: False
associated disease: Cutaneous ulcerations, deep abscesses
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MymaA.01625.a.A1.GE30227 Full length( MymaA.01625.a ) 1 403 GE30227
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Structures

image of structure for 3RV2
3RV2
Deposited: 5/5/2011
Determination: XRay
Diffraction Image
Clone: MymaA.01625.a.A1.GE30227
Protein: MymaA.01625.a.A1.PW30103

Publications by SSGCID

Increasing the structural coverage of tuberculosis drug targets.
Abendroth J, Abramov A, Armour B, Barrett LK, Baugh L, Begley DW, Buchko GW, Choi R, Clifton MC, Dieterich SH, Dranow DM, Edwards TE, Fairman JW, Ferrell M, Fox D, Gardberg AS, Hewitt SN, Lorimer D, Lyons-Abbott S, Mundt E, Muruthi MM, Myers J, Myler PJ, Napuli AJ, Phan I, Sekar A, Serbzhinskiy D, Stacy R, Staker BL, Stewart LJ, Taylor BM, Thompkins K, Tran N, Van Voorhis WC, Zhang Y
Tuberculosis (Edinb) - 2014
volume 95, issue 2, pages 142-8
PMID: 25613812; PMCID: PMC4361283
PDB: 3GVC, 3GVG, 3GWC, 3H7F, 3H81, 3HE2, 3HWI, 3HWK, 3HZG, 3ICO, 3KHP, 3LLS, 3MOY, 3MPZ, 3MYB, 3NDN, 3NDO, 3NF4, 3NG3, 3NJD, 3NWO, 3O0M, 3O38, 3OC6, 3OC7, 3OEC, 3OI9, 3OKS, 3OL3, 3OL4, 3OME, 3P0T, 3P2Y, 3P4I, 3P4T, 3P5M, 3P85, 3PE8, 3PGX, 3PK0, 3PPI, 3PXX, 3PZY, 3Q1T, 3Q8N, 3QBP, 3QDF, 3QH4, 3QHA, 3QIV, 3QK8, 3QKA, 3QLJ, 3QMJ, 3QRE, 3QUA, 3QUV, 3QXI, 3QXZ, 3QYR, 3R0O, 3R1I, 3R1J, 3R20, 3R2N, 3R4T, 3R6H, 3R6O, 3R7K, 3R8C, 3R9P, 3R9Q, 3R9R, 3R9S, 3R9T, 3RD5, 3RD7, 3RD8, 3RFQ, 3RIH, 3RR2, 3RR6, 3RRP, 3RRV, 3RSI, 3RV2, 3S55, 3S82, 3SBX, 3SF6, 3SLL, 3SVK, 3SVT, 3SWO, 3SWT, 3SWX, 3SX2, 3T3W, 3T7C, 3TAV, 3TCR, 3TDE, 3TJR, 3TL3, 3TLF, 3TRR, 3TSC, 3TX2, 3TZQ, 3TZU, 3U0A, 3U0B, 3UCX, 3UVE, 4DI1, 4DIE, 4DQ8, 4DXL, 4ED4, 4EGE, 4EGF, 4EMD, 4EO9, 4EYE, 4F3W, 4F47, 4FFC, 4GK6, 4HDT, 4HR3, 4I1Y, 4IJN, 4IV6, 4IZ9, 4J5I, 4KAM, 4LGV, 4O2D, 5EJ2

Citations by Others

Synthesis of non-natural cofactor analogs of S-adenosyl-L-methionine using methionine adenosyltransferase
J Thorson, T Huber, J Zhang, S Singh- US Patent 9,879,043, 2018 - freepatentsonline.com
PDB: 3RV2

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_126734
PATRIC ID: fig|216594.6.peg.2356
RefSeq: YP_001850509.1
UniProt: B2HP50

Enzyme & Pathway Information

Pathway Pathway ID EC Number
ethylene biosynthesis I (plants) ETHYL-PWY 2.5.1.6
L-methionine degradation I (to L-homocysteine) METHIONINE-DEG1-PWY 2.5.1.6
superpathway of S-adenosyl-L-methionine biosynthesis MET-SAM-PWY 2.5.1.6
aspartate superpathway PWY0-781 2.5.1.6
S-adenosyl-L-methionine cycle II PWY-5041 2.5.1.6
superpathway of L-methionine salvage and degradation PWY-5328 2.5.1.6
2'-deoxymugineic acid phytosiderophore biosynthesis PWY-5912 2.5.1.6
S-adenosyl-L-methionine cycle I PWY-6151 2.5.1.6
superpathway of L-cysteine biosynthesis (mammalian) PWY-6292 2.5.1.6
L-methionine salvage cycle II (plants) PWY-7270 2.5.1.6
L-methionine salvage cycle III PWY-7527 2.5.1.6
L-methionine salvage cycle I (bacteria and plants) PWY-7528 2.5.1.6
L-cysteine biosynthesis VI (from L-methionine) PWY-I9 2.5.1.6
S-adenosyl-L-methionine biosynthesis SAM-PWY 2.5.1.6

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MSEKGRLFTS ESVTEGHPDK ICDAVSDSVL DALLAADPRS RVAVETLVTT GQVHVVGEVT TTAKEAFADI TNIVRERILD IGYDSSDKGF DGASCGVNIG IGAQSPDIAQ GVDTAHEARV EGAADPLDAQ GAGDQGLMFG YAINDTPELM PLPIALAHRL SRRLTEVRKN GVLPYLRPDG KTQVTIAYED RVPVRLDTVV ISTQHADDID LVKTLDPDIR EQVLKTVLDD LAHDTLDASA VRVLVNPTGK FVLGGPMGDA GLTGRKIIVD TYGGWARHGG GAFSGKDPSK VDRSAAYAMR WVAKNVVAAG LAERVEVQVA YAIGKAAPVG LFVETFGSEA VDPVKIEKAI GEVFDLRPGA IIRDLNLLRP IYAPTAAYGH FGRTDVDLPW ERLDKVDDLK RAI

NT Sequence
GTGAGTGAAA AGGGTCGCCT TTTTACCAGT GAGTCGGTGA CGGAAGGACA TCCCGACAAG ATCTGTGACG CGGTCAGCGA CTCGGTCCTC GACGCGCTTC TGGCGGCGGA CCCCCGCTCG CGTGTTGCAG TTGAGACCCT GGTGACCACC GGGCAGGTGC ACGTGGTGGG TGAGGTCACG ACGACCGCCA AGGAGGCGTT CGCTGACATC ACCAATATCG TTCGCGAACG CATCCTCGAC ATCGGCTACG ACTCGTCGGA CAAGGGCTTC GACGGGGCAT CCTGCGGAGT GAACATCGGT ATCGGAGCCC AGTCGCCCGA CATCGCACAA GGTGTTGATA CCGCCCATGA GGCCCGCGTC GAGGGCGCTG CGGATCCGTT GGACGCGCAA GGCGCCGGCG ACCAGGGCCT GATGTTCGGT TACGCGATCA ACGACACCCC GGAGCTGATG CCGCTGCCGA TCGCGCTGGC TCACCGGTTG TCGCGGCGAC TGACCGAGGT CCGCAAGAAC GGTGTGCTGC CCTACTTGCG CCCGGATGGC AAGACTCAGG TCACCATCGC CTACGAGGAC CGGGTGCCGG TGCGGCTGGA CACGGTGGTC ATTTCGACCC AGCATGCGGA CGACATCGAC CTGGTGAAGA CGCTGGATCC CGACATTCGC GAGCAGGTGC TCAAGACCGT GCTCGACGAC CTGGCCCACG ACACCCTGGA TGCCTCGGCG GTGCGGGTGC TGGTCAACCC GACCGGAAAG TTCGTCCTTG GCGGACCGAT GGGCGATGCG GGCCTCACCG GCCGCAAGAT CATCGTCGAC ACCTACGGCG GGTGGGCCCG GCACGGTGGT GGCGCATTCT CCGGCAAGGA TCCGTCCAAG GTGGACCGCT CGGCGGCGTA CGCGATGCGC TGGGTGGCCA AAAACGTGGT CGCAGCGGGG CTGGCCGAGC GGGTCGAGGT ACAGGTGGCC TACGCCATCG GCAAAGCCGC CCCGGTCGGC CTGTTCGTGG AGACATTCGG CTCCGAGGCT GTCGACCCGG TCAAGATCGA GAAGGCCATC GGTGAGGTGT TCGACCTGCG GCCTGGCGCG ATCATTCGCG ACCTGAACCT GCTGCGGCCC ATCTATGCGC CCACCGCCGC TTACGGGCAC TTCGGTCGCA CCGATGTCGA CCTGCCGTGG GAGCGGCTCG ACAAGGTCGA CGACCTCAAG CGCGCCATC

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