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Seattle Structural Genomics Center for Infectious Disease

MypaA.00640.a: Acetate kinase (EC=2.7.2.1) (AckA)

Target Characteristics

from organism: Mycobacterium paratuberculosis ATCC BAA-968 / K-10
most recent status: in PDB
center reference id: MypaA.00640.a
is community request: False
associated disease: Johne's disease
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MypaA.00640.a.A1.GE29470 Full length( MypaA.00640.a ) 1 387 GE29470
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Structures

image of structure for 3R9P
3R9P
Deposited: 3/25/2011
Determination: XRay
Diffraction Image
Clone: MypaA.00640.a.A1.GE29470
Protein: MypaA.00640.a.A1.PS00722

Publications by SSGCID

Increasing the structural coverage of tuberculosis drug targets.
Abendroth J, Abramov A, Armour B, Barrett LK, Baugh L, Begley DW, Buchko GW, Choi R, Clifton MC, Dieterich SH, Dranow DM, Edwards TE, Fairman JW, Ferrell M, Fox D, Gardberg AS, Hewitt SN, Lorimer D, Lyons-Abbott S, Mundt E, Muruthi MM, Myers J, Myler PJ, Napuli AJ, Phan I, Sekar A, Serbzhinskiy D, Stacy R, Staker BL, Stewart LJ, Taylor BM, Thompkins K, Tran N, Van Voorhis WC, Zhang Y
Tuberculosis (Edinb) - 2014
volume 95, issue 2, pages 142-8
PMID: 25613812; PMCID: PMC4361283
PDB: 3GVC, 3GVG, 3GWC, 3H7F, 3H81, 3HE2, 3HWI, 3HWK, 3HZG, 3ICO, 3KHP, 3LLS, 3MOY, 3MPZ, 3MYB, 3NDN, 3NDO, 3NF4, 3NG3, 3NJD, 3NWO, 3O0M, 3O38, 3OC6, 3OC7, 3OEC, 3OI9, 3OKS, 3OL3, 3OL4, 3OME, 3P0T, 3P2Y, 3P4I, 3P4T, 3P5M, 3P85, 3PE8, 3PGX, 3PK0, 3PPI, 3PXX, 3PZY, 3Q1T, 3Q8N, 3QBP, 3QDF, 3QH4, 3QHA, 3QIV, 3QK8, 3QKA, 3QLJ, 3QMJ, 3QRE, 3QUA, 3QUV, 3QXI, 3QXZ, 3QYR, 3R0O, 3R1I, 3R1J, 3R20, 3R2N, 3R4T, 3R6H, 3R6O, 3R7K, 3R8C, 3R9P, 3R9Q, 3R9R, 3R9S, 3R9T, 3RD5, 3RD7, 3RD8, 3RFQ, 3RIH, 3RR2, 3RR6, 3RRP, 3RRV, 3RSI, 3RV2, 3S55, 3S82, 3SBX, 3SF6, 3SLL, 3SVK, 3SVT, 3SWO, 3SWT, 3SWX, 3SX2, 3T3W, 3T7C, 3TAV, 3TCR, 3TDE, 3TJR, 3TL3, 3TLF, 3TRR, 3TSC, 3TX2, 3TZQ, 3TZU, 3U0A, 3U0B, 3UCX, 3UVE, 4DI1, 4DIE, 4DQ8, 4DXL, 4ED4, 4EGE, 4EGF, 4EMD, 4EO9, 4EYE, 4F3W, 4F47, 4FFC, 4GK6, 4HDT, 4HR3, 4I1Y, 4IJN, 4IV6, 4IZ9, 4J5I, 4KAM, 4LGV, 4O2D, 5EJ2

Citations by Others

Investigation of pyrophosphate versus ATP substrate selection in the Entamoeba histolytica acetate kinase
T Dang, C Ingram-Smith- Scientific Reports, 2017 - ncbi.nlm.nih.gov
PDB: 3R9P

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_130287
PATRIC ID: fig|262316.17.peg.4137
RefSeq: NP_962820.1
UniProt: Q73T33

Enzyme & Pathway Information

Pathway Pathway ID EC Number
(S)-propane-1,2-diol degradation PWY-7013 2.7.2.1
superpathway of L-threonine metabolism THREOCAT-PWY 2.7.2.1

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MDGSDGARRV LVINSGSSSL KFQLVDPEFG VAASTGIVER IGEESSPVPD HDAALRRAFD MLAGDGVDLN TAGLVAVGHR VVHGGNTFYR PTVLDDAVIA RLHELSELAP LHNPPALQGI EVARRLLPDI AHVAVFDTGF FHDLPPAAAT YAIDRELADR WQIRRYGFHG TSHRYVSEQA AAFLDRPLRG LKQIVLHLGN GCSASAIAGT RPLDTSMGLT PLEGLVMGTR SGDIDPSIVS YLCHTAGMGV DDVESMLNHR SGVVGLSGVR DFRRLRELIE SGDGAAQLAY SVFTHRLRKY IGAYLAVLGH TDVISFTAGI GENDAAVRRD AVSGMEELGI VLDERRNLAG GKGARQISAD DSPITVLVVP TNEELAIARD CVRVLGG

NT Sequence
GTGGACGGTA GCGACGGCGC GCGCCGGGTG CTGGTGATCA ACTCCGGCTC GTCGTCGCTG AAGTTCCAGC TGGTCGATCC CGAGTTCGGG GTGGCCGCCT CGACGGGCAT CGTGGAACGC ATCGGCGAGG AATCCTCGCC GGTCCCCGAC CACGACGCCG CGCTGCGCCG AGCGTTCGAC ATGCTGGCCG GCGACGGCGT CGACCTGAAC ACCGCCGGGC TGGTCGCGGT GGGTCATCGG GTGGTGCACG GCGGCAACAC CTTCTACCGG CCCACCGTGC TGGACGACGC GGTGATCGCC CGGCTGCACG AGCTGTCGGA GTTGGCCCCG CTGCACAATC CGCCGGCGCT CCAGGGAATC GAAGTGGCCC GCCGGCTGTT GCCCGACATC GCGCACGTGG CCGTCTTCGA CACCGGGTTC TTCCACGACC TGCCGCCCGC GGCGGCGACC TACGCCATCG ACCGCGAATT GGCCGATCGC TGGCAGATCC GCCGGTACGG GTTCCACGGC ACCTCGCACC GCTACGTCAG CGAGCAGGCC GCGGCCTTCC TGGATCGGCC GCTGCGCGGC CTGAAACAGA TCGTGCTGCA CCTGGGCAAC GGCTGCTCGG CGTCGGCGAT CGCCGGCACC CGGCCCCTCG ACACCTCGAT GGGGTTGACG CCGCTGGAGG GACTGGTGAT GGGAACCCGC AGCGGTGACA TCGATCCCAG CATCGTCAGC TATCTGTGCC ACACGGCCGG GATGGGGGTG GACGACGTCG AGTCGATGCT CAACCACCGC TCGGGGGTGG TGGGGCTGTC CGGCGTGCGG GACTTCCGCC GGCTGCGCGA ACTCATCGAA TCCGGTGACG GCGCAGCGCA ATTGGCCTAC AGCGTGTTCA CGCACCGGCT GCGCAAGTAC ATCGGAGCCT ACCTGGCGGT GCTGGGCCAC ACCGACGTCA TCAGCTTCAC CGCCGGCATC GGTGAGAACG ACGCCGCGGT GCGCCGCGAC GCGGTGTCCG GCATGGAGGA GCTGGGCATC GTGCTCGACG AGCGCCGCAA CCTCGCCGGG GGCAAAGGGG CACGCCAGAT CTCGGCCGAC GACTCGCCGA TCACGGTGCT GGTGGTCCCC ACCAACGAAG AGCTGGCCAT CGCCCGTGAC TGCGTGCGGG TGCTAGGCGG A

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