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Seattle Structural Genomics Center for Infectious Disease

MypaA.00725.a: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE)

Target Characteristics

from organism: Mycobacterium paratuberculosis ATCC BAA-968 / K-10
most recent status: selected
center reference id: MypaA.00725.a
is community request: True
associated disease: Johne's disease
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

External Resources

Resource Reference ID
OrthoMCL: OG5_130885
PATRIC ID: fig|262316.17.peg.1020
RefSeq: NP_959910.1
UniProt: Q741W1

Enzyme & Pathway Information

Pathway Pathway ID EC Number
methylerythritol phosphate pathway I NONMEVIPP-PWY 2.7.1.148
superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) PWY-5121 2.7.1.148
isoprene biosynthesis I PWY-6270 2.7.1.148
superpathway of ergosterol biosynthesis II PWY-7156 2.7.1.148
taxadiene biosynthesis (engineered) PWY-7392 2.7.1.148
methylerythritol phosphate pathway II PWY-7560 2.7.1.148

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MSDGNTAAAW VPTGSVTVRV PGKVNLYLAV GDRREDGYHE LTTIFQAVSL LDEVTVRNAD VLSLDIVGEG ADKLPTDERN LAWQAAELMA DHVGRAPDVS IMIDKSIPVA GGMAGGSADA AAVLVAMNSL WELNVPRRDL RMLAARLGSD VPFALHGGTA LGTGRGEELA TVLSRNTFHW VLAFADGELL TRKVFAELDR LRRAGDPPRL PGPGPVLAAL AAGDADQLAP LLGNEMQAAA VSLNPGLRRT LRAGVQAGAL AGIVSGSGPT CAFLCPSAAA AVDVGTEVSG VGVCRTVRVA SGPVAGARVV PAPTEV

NT Sequence
ATGTCTGACG GCAACACCGC CGCGGCTTGG GTGCCCACCG GGTCGGTCAC CGTCCGGGTG CCCGGAAAAG TCAACCTCTA CCTGGCCGTC GGCGATCGCC GCGAGGACGG CTACCACGAG CTGACCACGA TTTTTCAGGC CGTCTCGCTG CTCGACGAGG TGACCGTGCG CAACGCCGAC GTGCTCTCGC TCGACATCGT CGGCGAGGGC GCCGACAAAC TGCCCACCGA CGAACGCAAC CTGGCCTGGC AGGCCGCCGA GCTGATGGCC GACCACGTCG GCCGGGCGCC GGACGTGTCG ATCATGATCG ACAAGTCCAT TCCGGTGGCC GGCGGGATGG CCGGCGGTAG CGCCGACGCG GCGGCGGTGC TGGTCGCGAT GAACTCGCTG TGGGAGCTCA ACGTGCCTCG CCGCGATCTG CGCATGCTCG CCGCGCGGCT GGGCAGCGAC GTGCCGTTTG CGTTGCACGG CGGCACCGCG CTGGGCACCG GCCGCGGCGA GGAGCTGGCG ACGGTATTGT CCCGCAACAC CTTTCACTGG GTGCTGGCGT TCGCCGACGG CGAGCTGCTG ACCCGCAAGG TGTTCGCCGA GCTGGACCGG CTGCGGCGCG CGGGCGATCC GCCGCGGCTG CCCGGGCCGG GCCCGGTGCT GGCCGCGCTG GCCGCCGGCG ACGCCGACCA GTTGGCGCCG CTGTTGGGCA ATGAAATGCA GGCCGCCGCG GTGAGCCTGA ATCCCGGCCT GCGCCGCACC CTGCGCGCCG GCGTGCAGGC CGGCGCGCTG GCGGGCATCG TGTCGGGCTC CGGCCCGACG TGTGCCTTCC TGTGCCCGTC GGCGGCCGCG GCGGTGGACG TCGGCACCGA GGTGTCCGGG GTGGGGGTGT GCCGCACGGT GCGGGTCGCC AGCGGACCGG TGGCCGGTGC CCGCGTGGTC CCGGCACCGA CCGAGGTG

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