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Seattle Structural Genomics Center for Infectious Disease

MysmA.01026.b: 4-aminobutyrate transaminase

Target Characteristics

from organism: Mycobacterium smegmatis ATCC 700084 / mc(2)155
most recent status: in PDB
center reference id: MysmA.01026.b
is community request: False
associated disease:
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MysmA.01026.b.A1.PW28765 Full length( MysmA.01026.b ) 1 448

Structures

image of structure for 3Q8N
3Q8N
Deposited: 1/6/2011
Determination: XRay
Diffraction Image
Clone: MysmA.01026.b.A1.GE28860
Protein: MysmA.01026.b.A1.PW28765

Publications by SSGCID

Increasing the structural coverage of tuberculosis drug targets.
Abendroth J, Abramov A, Armour B, Barrett LK, Baugh L, Begley DW, Buchko GW, Choi R, Clifton MC, Dieterich SH, Dranow DM, Edwards TE, Fairman JW, Ferrell M, Fox D, Gardberg AS, Hewitt SN, Lorimer D, Lyons-Abbott S, Mundt E, Muruthi MM, Myers J, Myler PJ, Napuli AJ, Phan I, Sekar A, Serbzhinskiy D, Stacy R, Staker BL, Stewart LJ, Taylor BM, Thompkins K, Tran N, Van Voorhis WC, Zhang Y
Tuberculosis (Edinb) - 2014
volume 95, issue 2, pages 142-8
PMID: 25613812; PMCID: PMC4361283
PDB: 3GVC, 3GVG, 3GWC, 3H7F, 3H81, 3HE2, 3HWI, 3HWK, 3HZG, 3ICO, 3KHP, 3LLS, 3MOY, 3MPZ, 3MYB, 3NDN, 3NDO, 3NF4, 3NG3, 3NJD, 3NWO, 3O0M, 3O38, 3OC6, 3OC7, 3OEC, 3OI9, 3OKS, 3OL3, 3OL4, 3OME, 3P0T, 3P2Y, 3P4I, 3P4T, 3P5M, 3P85, 3PE8, 3PGX, 3PK0, 3PPI, 3PXX, 3PZY, 3Q1T, 3Q8N, 3QBP, 3QDF, 3QH4, 3QHA, 3QIV, 3QK8, 3QKA, 3QLJ, 3QMJ, 3QRE, 3QUA, 3QUV, 3QXI, 3QXZ, 3QYR, 3R0O, 3R1I, 3R1J, 3R20, 3R2N, 3R4T, 3R6H, 3R6O, 3R7K, 3R8C, 3R9P, 3R9Q, 3R9R, 3R9S, 3R9T, 3RD5, 3RD7, 3RD8, 3RFQ, 3RIH, 3RR2, 3RR6, 3RRP, 3RRV, 3RSI, 3RV2, 3S55, 3S82, 3SBX, 3SF6, 3SLL, 3SVK, 3SVT, 3SWO, 3SWT, 3SWX, 3SX2, 3T3W, 3T7C, 3TAV, 3TCR, 3TDE, 3TJR, 3TL3, 3TLF, 3TRR, 3TSC, 3TX2, 3TZQ, 3TZU, 3U0A, 3U0B, 3UCX, 3UVE, 4DI1, 4DIE, 4DQ8, 4DXL, 4ED4, 4EGE, 4EGF, 4EMD, 4EO9, 4EYE, 4F3W, 4F47, 4FFC, 4GK6, 4HDT, 4HR3, 4I1Y, 4IJN, 4IV6, 4IZ9, 4J5I, 4KAM, 4LGV, 4O2D, 5EJ2

Citations by Others

Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications
F Steffen-Munsberg, C Vickers, H Kohls, H Land… - Biotechnology …, 2015 - Elsevier
cited by: 51 others
PDB: 3Q8N
Biocatalytic Synthesis of Amino Alcohols
H Kohls - 2015 - d-nb.info
PDB: 3Q8N
MODELING AND DOCKING STUDIES OF 4-AMINOBUTYRATE AMINOTRANSFERASE FOR HUNTINGTON'S DISEASE.
H Pareek, P Thakur, D Ray - International Journal of Pharma & Bio Sciences, 2011 - search.ebscohost.com
PDB: 3Q8N

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_128761
PATRIC ID: fig|246196.19.peg.578
RefSeq: YP_884992.1
UniProt: A0QQ04

Enzyme & Pathway Information

Pathway Pathway ID EC Number
superpathway of 4-aminobutanoate degradation 4AMINOBUTMETAB-PWY 2.6.1.19
superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation ARGDEG-PWY 2.6.1.19
beta-alanine degradation I BETA-ALA-DEGRADATION-I-PWY 2.6.1.19
GABA shunt GLUDEG-I-PWY 2.6.1.19
superpathway of L-arginine and L-ornithine degradation ORNARGDEG-PWY 2.6.1.19
nicotine degradation I (pyridine pathway) P181-PWY 2.6.1.19
glutamate degradation IX (via 4-aminobutyrate) PWY3O-210 2.6.1.19
L-glutamate degradation IV PWY-4321 2.6.1.19
4-aminobutanoate degradation V PWY-5022 2.6.1.19
4-aminobutanoate degradation I PWY-6535 2.6.1.19
4-aminobutanoate degradation III PWY-6536 2.6.1.19
4-aminobutanoate degradation II PWY-6537 2.6.1.19

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MTIAEIAGRT LTQERRLVTA IPGPISQELQ ARKQSAVAAG VGVTLPVYVV AAGGGVLADA DGNQLIDFGS GIAVTTVGNS APAVVDAVTQ QVAAFTHTCF MVTPYEGYVK VAEHLNRLTP GDHEKRTALF NSGAEAVENA VKIARAYTRR QAVVVFDHAY HGRTNLTMAM TAKNQPYKHG FGPFANEVYR VPTSYPFRDG ETDGAAAAAH ALDLINKQVG ADNVAAVVIE PVHGEGGFVV PAPGFLGALQ KWCTDNGAVF VADEVQTGFA RTGALFACEH ENVVPDLIVT AKGIAGGLPL SAVTGRAEIM DGPQSGGLGG TYGGNPLACA AALAVIDTIE RENLVARARA IGETMLSRLG ALAAADPRIG EVRGRGAMIA VELVKPGTTE PDADLTKRVA AAAHAQGLVV LTCGTYGNVL RFLPPLSMPD HLLDEGLDIL AAVFAEVK

NT Sequence
GTGACCATCG CCGAGATCGC CGGTCGGACA CTCACCCAGG AACGCCGGCT CGTCACCGCC ATTCCCGGCC CGATCTCGCA GGAGCTGCAG GCGCGCAAGC AGAGTGCCGT GGCGGCGGGT GTCGGCGTGA CGCTGCCGGT CTACGTCGTC GCGGCCGGTG GCGGCGTGCT CGCGGACGCC GACGGCAACC AGCTCATCGA CTTCGGCTCG GGCATCGCCG TCACCACCGT CGGCAACAGC GCACCCGCCG TCGTCGACGC GGTGACGCAG CAGGTCGCAG CGTTCACCCA CACGTGCTTC ATGGTCACGC CCTACGAGGG ATACGTGAAG GTGGCCGAGC ACCTCAACCG GCTCACCCCG GGCGATCACG AGAAGCGCAC GGCGCTGTTC AACTCCGGCG CCGAAGCCGT CGAGAACGCG GTCAAGATCG CGCGTGCCTA CACCCGCAGG CAGGCGGTGG TGGTGTTCGA CCACGCCTAC CACGGCCGCA CCAACCTGAC CATGGCGATG ACCGCCAAGA ACCAGCCGTA CAAGCACGGC TTCGGCCCGT TCGCCAACGA GGTGTACCGC GTGCCCACGT CGTACCCGTT CCGCGACGGC GAGACCGACG GCGCGGCCGC CGCGGCGCAC GCCCTCGACC TGATCAACAA GCAGGTCGGC GCCGACAACG TCGCCGCCGT GGTGATCGAA CCCGTCCACG GTGAGGGCGG ATTTGTCGTT CCCGCACCGG GATTCCTCGG CGCTCTGCAG AAGTGGTGCA CCGACAACGG CGCGGTGTTC GTCGCCGACG AGGTGCAGAC CGGATTCGCC CGCACCGGTG CGCTGTTCGC GTGCGAGCAC GAGAACGTGG TGCCCGATCT GATCGTCACC GCCAAGGGCA TCGCAGGCGG TCTGCCGCTG TCGGCGGTGA CCGGTCGCGC CGAGATCATG GACGGCCCGC AGTCCGGTGG CCTCGGCGGC ACCTACGGCG GCAACCCGCT GGCGTGTGCC GCCGCGCTCG CGGTGATCGA CACCATCGAG CGTGAAAACC TCGTCGCGCG GGCCCGCGCG ATCGGCGAGA CCATGCTGAG CCGCCTCGGT GCGCTCGCCG CAGCCGATCC GCGCATCGGC GAGGTGCGTG GCCGCGGCGC CATGATCGCT GTCGAACTGG TCAAGCCGGG CACCACCGAG CCCGACGCCG ACCTGACCAA GCGCGTCGCC GCCGCTGCGC ACGCGCAGGG CCTGGTGGTG CTGACGTGCG GCACCTACGG CAACGTGCTG CGCTTCCTGC CCCCGCTGAG CATGCCCGAC CACCTGCTCG ACGAAGGACT CGACATCCTG GCCGCAGTGT TCGCAGAGGT GAAG

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