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Seattle Structural Genomics Center for Infectious Disease

MysmA.01026.c: 4-aminobutyrate transaminase

Target Characteristics

from organism: Mycobacterium smegmatis ATCC 700084 / mc(2)155
most recent status: in PDB
center reference id: MysmA.01026.c
is community request: False
associated disease:
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

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Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MysmA.01026.c.A1.PW28766 Full length( MysmA.01026.c ) 1 446

Structures

image of structure for 3OKS
3OKS
Deposited: 8/25/2010
Determination: XRay
Diffraction Image
Clone: MysmA.01026.c.A1.GE28861
Protein: MysmA.01026.c.A1.PW28766

Publications by SSGCID

Increasing the structural coverage of tuberculosis drug targets.
Abendroth J, Abramov A, Armour B, Barrett LK, Baugh L, Begley DW, Buchko GW, Choi R, Clifton MC, Dieterich SH, Dranow DM, Edwards TE, Fairman JW, Ferrell M, Fox D, Gardberg AS, Hewitt SN, Lorimer D, Lyons-Abbott S, Mundt E, Muruthi MM, Myers J, Myler PJ, Napuli AJ, Phan I, Sekar A, Serbzhinskiy D, Stacy R, Staker BL, Stewart LJ, Taylor BM, Thompkins K, Tran N, Van Voorhis WC, Zhang Y
Tuberculosis (Edinb) - 2014
volume 95, issue 2, pages 142-8
PMID: 25613812; PMCID: PMC4361283
PDB: 3GVC, 3GVG, 3GWC, 3H7F, 3H81, 3HE2, 3HWI, 3HWK, 3HZG, 3ICO, 3KHP, 3LLS, 3MOY, 3MPZ, 3MYB, 3NDN, 3NDO, 3NF4, 3NG3, 3NJD, 3NWO, 3O0M, 3O38, 3OC6, 3OC7, 3OEC, 3OI9, 3OKS, 3OL3, 3OL4, 3OME, 3P0T, 3P2Y, 3P4I, 3P4T, 3P5M, 3P85, 3PE8, 3PGX, 3PK0, 3PPI, 3PXX, 3PZY, 3Q1T, 3Q8N, 3QBP, 3QDF, 3QH4, 3QHA, 3QIV, 3QK8, 3QKA, 3QLJ, 3QMJ, 3QRE, 3QUA, 3QUV, 3QXI, 3QXZ, 3QYR, 3R0O, 3R1I, 3R1J, 3R20, 3R2N, 3R4T, 3R6H, 3R6O, 3R7K, 3R8C, 3R9P, 3R9Q, 3R9R, 3R9S, 3R9T, 3RD5, 3RD7, 3RD8, 3RFQ, 3RIH, 3RR2, 3RR6, 3RRP, 3RRV, 3RSI, 3RV2, 3S55, 3S82, 3SBX, 3SF6, 3SLL, 3SVK, 3SVT, 3SWO, 3SWT, 3SWX, 3SX2, 3T3W, 3T7C, 3TAV, 3TCR, 3TDE, 3TJR, 3TL3, 3TLF, 3TRR, 3TSC, 3TX2, 3TZQ, 3TZU, 3U0A, 3U0B, 3UCX, 3UVE, 4DI1, 4DIE, 4DQ8, 4DXL, 4ED4, 4EGE, 4EGF, 4EMD, 4EO9, 4EYE, 4F3W, 4F47, 4FFC, 4GK6, 4HDT, 4HR3, 4I1Y, 4IJN, 4IV6, 4IZ9, 4J5I, 4KAM, 4LGV, 4O2D, 5EJ2

Citations by Others

YASARA: A Tool to Obtain Structural Guidance in Biocatalytic Investigations
H Land, MS Humble- Protein Engineering, 2018 - Springer
cited by: 110 others
PDB: 3OKS
Single active‐site mutants are sufficient to enhance serine: pyruvate α‐transaminase activity in an ω‐transaminase
D Deszcz, P Affaticati, N Ladkau, A Gegel… - FEBS …, 2015 - Wiley Online Library
cited by: 9 others
PDB: 3OKS
Rare Sidechain Conformations in Proteins and DNA
BJ Hintze - 2015 - search.proquest.com
PDB: 3OKS
Structures of a gamma-aminobutyrate (GABA) transaminase from the s-triazine-degrading organism Arthrobacter aurescens TC1 in complex with PLP and with its external aldimine PLP-GABA adduct
H Bruce, A Nguyen Tuan? - Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2012 - scripts.iucr.org
cited by: 1 other
PDB: 3OKS

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_128761
PATRIC ID: fig|246196.19.peg.2922
RefSeq: YP_887278.1
UniProt: A0QWJ0

Enzyme & Pathway Information

Pathway Pathway ID EC Number
superpathway of 4-aminobutanoate degradation 4AMINOBUTMETAB-PWY 2.6.1.19
superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation ARGDEG-PWY 2.6.1.19
beta-alanine degradation I BETA-ALA-DEGRADATION-I-PWY 2.6.1.19
GABA shunt GLUDEG-I-PWY 2.6.1.19
superpathway of L-arginine and L-ornithine degradation ORNARGDEG-PWY 2.6.1.19
nicotine degradation I (pyridine pathway) P181-PWY 2.6.1.19
glutamate degradation IX (via 4-aminobutyrate) PWY3O-210 2.6.1.19
L-glutamate degradation IV PWY-4321 2.6.1.19
4-aminobutanoate degradation V PWY-5022 2.6.1.19
4-aminobutanoate degradation I PWY-6535 2.6.1.19
4-aminobutanoate degradation III PWY-6536 2.6.1.19
4-aminobutanoate degradation II PWY-6537 2.6.1.19

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MSHPEQSRHL ATAIPGPRSQ ALIDRKGTAV ARGVGTTMPV YAVRAGGGIV EDVDGNRLID LGSGIAVTTV GNSAPKVVEA VRSQVGDFTH TCFMVTPYEG YVAVCEQLNR LTPVRGDKRS ALFNSGSEAV ENAVKIARSH THKPAVVAFD HAYHGRTNLT MALTAKVMPY KDGFGPFAPE IYRAPLSYPF RDAEFGKELA TDGELAAKRA ITVIDKQIGA DNLAAVVIEP IQGEGGFIVP ADGFLPTLLD WCRKNDVVFI ADEVQTGFAR TGAMFACEHE GIDPDLIVTA KGIAGGLPLS AVTGRAEIMD SPHVSGLGGT YGGNPIACAA ALATIETIES EGLVARAQQI EKIMKDRLGR LQAEDDRIGD VRGRGAMIAM ELVKAGTTEP DADLTKALCA GAHAAGVIVL SCGTYGNVVR FLPPLSIGDD LLNEGLDVLE EVLRGA

NT Sequence
GTGAGCCATC CCGAGCAGAG CCGCCATCTC GCCACCGCCA TACCTGGGCC GAGATCCCAG GCACTGATCG ACAGGAAGGG CACAGCCGTC GCCCGCGGCG TCGGCACCAC GATGCCGGTC TACGCGGTCA GGGCCGGCGG CGGCATAGTC GAGGATGTCG ACGGCAACCG GCTGATCGAC CTCGGATCAG GCATTGCCGT CACCACCGTG GGCAACTCCG CGCCGAAGGT CGTCGAGGCC GTGCGCAGCC AGGTCGGCGA CTTCACCCAC ACATGCTTCA TGGTGACGCC GTACGAGGGG TACGTCGCGG TCTGCGAGCA ACTCAACCGG CTGACCCCGG TCCGCGGTGA CAAACGCTCG GCCCTGTTCA ACTCGGGTTC GGAGGCCGTC GAGAACGCCG TCAAGATCGC GCGGTCCCAC ACGCACAAAC CCGCGGTCGT CGCGTTCGAT CACGCCTATC ACGGCCGCAC CAACCTGACC ATGGCGCTGA CGGCCAAGGT CATGCCGTAC AAGGACGGGT TCGGACCGTT CGCGCCGGAG ATCTACCGCG CGCCGCTTTC CTATCCCTTC CGCGATGCCG AGTTCGGCAA GGAACTGGCG ACCGACGGCG AACTGGCGGC CAAGCGCGCG ATCACCGTCA TCGACAAGCA GATCGGCGCC GACAACCTCG CCGCGGTCGT CATCGAGCCG ATCCAGGGTG AGGGTGGCTT CATCGTGCCC GCCGACGGTT TCCTGCCGAC GCTGCTCGAC TGGTGCCGCA AGAACGATGT GGTGTTCATC GCCGACGAGG TCCAGACGGG TTTCGCGCGC ACGGGCGCGA TGTTCGCGTG CGAGCACGAG GGCATCGATC CCGATCTGAT CGTCACCGCC AAGGGCATCG CAGGCGGCCT GCCGCTGTCG GCGGTCACCG GACGCGCCGA GATCATGGAC TCGCCGCACG TGTCGGGACT CGGTGGCACG TACGGCGGCA ACCCGATCGC GTGCGCGGCC GCGCTGGCGA CCATCGAGAC CATCGAATCC GAGGGGCTCG TGGCGCGTGC GCAGCAGATC GAGAAGATCA TGAAGGACCG GCTCGGACGC CTGCAGGCCG AGGACGACCG CATCGGGGAT GTGCGGGGCC GCGGCGCGAT GATCGCGATG GAACTGGTCA AGGCCGGCAC CACCGAACCC GATGCCGACC TGACCAAGGC CCTGTGCGCA GGTGCGCACG CCGCGGGGGT GATCGTATTG TCTTGCGGCA CTTACGGAAA CGTGGTGCGT TTCCTGCCGC CGTTGTCGAT CGGTGACGAT CTGCTCAACG AGGGACTCGA CGTCCTCGAA GAGGTCCTCC GCGGCGCG

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