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Seattle Structural Genomics Center for Infectious Disease

MytuD.00556.a: succinyl-CoA synthetase subunit alpha

Target Characteristics

from organism: Mycobacterium tuberculosis H37Rv
most recent status: selected
center reference id: MytuD.00556.a
is community request: False
associated disease: Tuberculosis
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

External Resources

Resource Reference ID
OrthoMCL: OG5_127106
PATRIC ID: fig|83332.12.peg.1061
RefSeq: NP_215467.1
TubercuList: Rv0952
MTB Network Portal: Rv0952
UniProt: P9WGC7

Orthologues for Rv0952

Species % Identity % Coverage Clones Proteins Structures
marinum 92 99 0 0 0
ulcerans 91 99 1 0 0
leprae 86 99 1 0 0
smegmatis 86 99 0 0 0
thermoresistibile 86 99 1 0 0
abscessus 85 99 1 0 0
paratuberculosis 85 99 1 0 0
avium 84 99 0 0 0

Enzyme & Pathway Information

Pathway Pathway ID EC Number
superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass GLYCOLYSIS-TCA-GLYOX-BYPASS 6.2.1.5
reductive TCA cycle I P23-PWY 6.2.1.5
incomplete reductive TCA cycle P42-PWY 6.2.1.5
reductive TCA cycle II PWY-5392 6.2.1.5
superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle PWY-5464 6.2.1.5
pyruvate fermentation to acetate V PWY-5537 6.2.1.5
pyruvate fermentation to acetate VI PWY-5538 6.2.1.5
TCA cycle II (plants and fungi) PWY-5690 6.2.1.5
partial TCA cycle (obligate autotrophs) PWY-5913 6.2.1.5
Methanobacterium thermoautotrophicum biosynthetic metabolism PWY-6146 6.2.1.5
TCA cycle III (animals) PWY66-398 6.2.1.5
methylaspartate cycle PWY-6728 6.2.1.5
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase) PWY-6969 6.2.1.5
anaerobic energy metabolism (invertebrates, mitochondrial) PWY-7384 6.2.1.5
superpathway of anaerobic energy metabolism (invertebrates) PWY-7389 6.2.1.5
TCA cycle I (prokaryotic) TCA 6.2.1.5
superpathway of glyoxylate bypass and TCA TCA-GLYOX-BYPASS 6.2.1.5

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MTHMSIFLSR DNKVIVQGIT GSEATVHTAR MLRAGTQIVG GVNARKAGTT VTHEDKGGRL IKLPVFGSVA EAMEKTGADV SIIFVPPTFA KDAIIEAIDA EIPLLVVITE GIPVQDTAYA WAYNLEAGHK TRIIGPNCPG IISPGQSLAG ITPANITGPG PIGLVSKSGT LTYQMMFELR DLGFSTAIGI GGDPVIGTTH IDAIEAFERD PDTKLIVMIG EIGGDAEERA ADFIKTNVSK PVVGYVAGFT APEGKTMGHA GAIVSGSSGT AAAKQEALEA AGVKVGKTPS ATAALAREIL LSL

NT Sequence
ATGACTCACA TGTCCATATT TCTGAGCAGG GACAACAAGG TCATTGTGCA GGGCATCACC GGCAGTGAGG CCACCGTCCA TACCGCGCGA ATGCTGCGGG CGGGCACGCA AATCGTCGGC GGTGTGAACG CACGCAAAGC GGGCACCACC GTCACGCATG AGGATAAGGG CGGCCGGCTG ATCAAGCTGC CGGTGTTCGG CAGTGTCGCG GAGGCGATGG AAAAGACCGG CGCCGATGTG TCGATCATCT TCGTGCCGCC GACGTTCGCC AAGGACGCCA TCATCGAGGC CATCGACGCC GAAATTCCGC TGTTGGTTGT GATCACCGAG GGAATTCCGG TGCAGGACAC CGCCTATGCC TGGGCCTACA ACCTCGAGGC TGGCCACAAG ACCCGCATCA TTGGCCCCAA CTGTCCTGGC ATTATCAGTC CCGGTCAGTC GCTGGCCGGT ATCACGCCGG CCAACATCAC CGGACCCGGT CCAATTGGTC TGGTGTCCAA GTCGGGGACG TTGACCTACC AGATGATGTT CGAACTGCGC GACCTTGGAT TCTCCACGGC GATCGGCATC GGTGGTGATC CGGTGATTGG CACTACCCAC ATCGACGCCA TCGAGGCCTT CGAGAGGGAT CCGGACACCA AGCTCATCGT GATGATCGGC GAGATCGGTG GTGACGCCGA GGAGCGGGCC GCAGACTTCA TCAAGACCAA CGTGTCCAAG CCGGTCGTCG GCTATGTCGC CGGATTTACC GCACCCGAAG GCAAGACGAT GGGCCACGCC GGCGCCATCG TCTCCGGCTC GTCTGGCACA GCGGCGGCCA AGCAAGAGGC CCTGGAGGCC GCCGGTGTGA AGGTCGGCAA GACCCCATCG GCGACCGCGG CGCTGGCCCG GGAGATCTTG CTCAGTCTC

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