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Seattle Structural Genomics Center for Infectious Disease

MytuD.00654.a: acetyl-CoA acetyltransferase

Target Characteristics

from organism: Mycobacterium tuberculosis H37Rv
most recent status: expressed
center reference id: MytuD.00654.a
is community request: False
associated disease: Tuberculosis
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MytuD.00654.a.A1.GE30667 Full length( MytuD.00654.a ) 1 391 GE30667
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

External Resources

Resource Reference ID
OrthoMCL: NO_GROUP
PATRIC ID: fig|83332.12.peg.3960
RefSeq: NP_218063.1
TubercuList: Rv3546
MTB Network Portal: Rv3546
UniProt: I6XHI4

Orthologues for Rv3546

Species % Identity % Coverage Clones Proteins Structures
marinum 90 100 1 0 0
ulcerans 90 100 1 0 0
avium 86 100 0 0 0
paratuberculosis 86 100 0 0 0
smegmatis 83 100 0 1 0
abscessus 76 100 1 0 0

Enzyme & Pathway Information

Pathway Pathway ID EC Number
pyruvate fermentation to butanoate CENTFERM-PWY 2.3.1.16
superpathway of ergosterol biosynthesis I ERGOSTEROL-SYN-PWY 2.3.1.16
fatty acid beta-oxidation I FAO-PWY 2.3.1.16
L-glutamate degradation VII (to butanoate) GLUDEG-II-PWY 2.3.1.16
L-isoleucine degradation I ILEUDEG-PWY 2.3.1.16
L-glutamate degradation V (via hydroxyglutarate) P162-PWY 2.3.1.16
L-lysine fermentation to acetate and butanoate P163-PWY 2.3.1.16
polyhydroxybutanoate biosynthesis PWY1-3 2.3.1.16
fermentation to 2-methylbutanoate PWY-5109 2.3.1.16
fatty acid beta-oxidation II (peroxisome) PWY-5136 2.3.1.16
glutaryl-CoA degradation PWY-5177 2.3.1.16
toluene degradation VI (anaerobic) PWY-5184 2.3.1.16
superpathway of L-lysine degradation PWY-5327 2.3.1.16
superpathway of glyoxylate cycle and fatty acid degradation PWY-561 2.3.1.16
acetyl-CoA fermentation to butanoate II PWY-5676 2.3.1.16
ethylmalonyl-CoA pathway PWY-5741 2.3.1.16
3-hydroxypropanoate/4-hydroxybutanate cycle PWY-5789 2.3.1.16
superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) PWY-5910 2.3.1.16
Methanobacterium thermoautotrophicum biosynthetic metabolism PWY-6146 2.3.1.16
mevalonate pathway II (archaea) PWY-6174 2.3.1.16
4-hydroxybenzoate biosynthesis III (plants) PWY-6435 2.3.1.16
pyruvate fermentation to butanol I PWY-6583 2.3.1.16
pyruvate fermentation to acetone PWY-6588 2.3.1.16
superpathway of Clostridium acetobutylicum acidogenic fermentation PWY-6590 2.3.1.16
superpathway of Clostridium acetobutylicum solventogenic fermentation PWY-6594 2.3.1.16
superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation PWY-6604 2.3.1.16
ketogenesis PWY66-367 2.3.1.16
ketolysis PWY66-368 2.3.1.16
fatty acid beta-oxidation VI (peroxisome) PWY66-391 2.3.1.16
superpathway of cholesterol biosynthesis PWY66-5 2.3.1.16
pyruvate fermentation to hexanol (engineered) PWY-6863 2.3.1.16
isopropanol biosynthesis (engineered) PWY-6876 2.3.1.16
pyruvate fermentation to butanol II (engineered) PWY-6883 2.3.1.16
1-butanol autotrophic biosynthesis (engineered) PWY-6886 2.3.1.16
superpathway of cholesterol degradation I (cholesterol oxidase) PWY-6928 2.3.1.16
superpathway of testosterone and androsterone degradation PWY-6937 2.3.1.16
androstenedione degradation PWY-6944 2.3.1.16
cholesterol degradation to androstenedione I (cholesterol oxidase) PWY-6945 2.3.1.16
cholesterol degradation to androstenedione II (cholesterol dehydrogenase) PWY-6946 2.3.1.16
superpathway of cholesterol degradation II (cholesterol dehydrogenase) PWY-6947 2.3.1.16
sitosterol degradation to androstenedione PWY-6948 2.3.1.16
glycerol degradation to butanol PWY-7003 2.3.1.16
fatty acid salvage PWY-7094 2.3.1.16
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered) PWY-7216 2.3.1.16
photosynthetic 3-hydroxybutanoate biosynthesis (engineered) PWY-7218 2.3.1.16
fatty acid beta-oxidation (peroxisome, yeast) PWY-7288 2.3.1.16
10-cis-heptadecenoyl-CoA degradation (yeast) PWY-7337 2.3.1.16
10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast) PWY-7338 2.3.1.16
10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast) PWY-7339 2.3.1.16
9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast) PWY-7340 2.3.1.16
jasmonic acid biosynthesis PWY-735 2.3.1.16
isoprene biosynthesis II (engineered) PWY-7391 2.3.1.16
crotonate fermentation (to acetate and cyclohexane carboxylate) PWY-7401 2.3.1.16
benzoate fermentation (to acetate and cyclohexane carboxylate) PWY-7402 2.3.1.16
mevalonate pathway III (archaea) PWY-7524 2.3.1.16
docosahexaenoate biosynthesis III (6-desaturase, mammals) PWY-7606 2.3.1.16
(8E,10E)-dodeca-8,10-dienol biosynthesis PWY-7654 2.3.1.16
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase) PWY-7726 2.3.1.16
2-methylpropene degradation PWY-7778 2.3.1.16
methyl tert-butyl ether degradation PWY-7779 2.3.1.16
4-oxopentanoate degradation PWY-7948 2.3.1.16
mevalonate pathway I PWY-922 2.3.1.16
L-tryptophan degradation III (eukaryotic) TRYPTOPHAN-DEGRADATION-1 2.3.1.16
acetoacetate degradation (to acetyl CoA) ACETOACETATE-DEG-PWY 2.3.1.9

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MGYPVIVEAT RSPIGKRNGW LSGLHATELL GAVQKAVVDK AGIQSGLHAG DVEQVIGGCV TQFGEQSNNI SRVAWLTAGL PEHVGATTVD CQCGSGQQAN HLIAGLIAAG AIDVGIACGI EAMSRVGLGA NAGPDRSLIR AQSWDIDLPN QFEAAERIAK RRGITREDVD VFGLESQRRA QRAWAEGRFD REISPIQAPV LDEQNQPTGE RRLVFRDQGL RETTMAGLGE LKPVLEGGIH TAGTSSQISD GAAAVLWMDE AVARAHGLTP RARIVAQALV GAEPYYHLDG PVQSTAKVLE KAGMKIGDID IVEINEAFAS VVLSWARVHE PDMDRVNVNG GAIALGHPVG CTGSRLITTA LHELERTDQS LALITMCAGG ALSTGTIIER I

NT Sequence
ATGGGTTACC CGGTCATCGT TGAAGCCACC CGCAGCCCCA TCGGCAAACG CAACGGATGG CTGTCGGGGC TGCATGCCAC CGAGTTGTTG GGCGCGGTGC AAAAGGCGGT GGTCGACAAG GCCGGCATCC AGTCCGGCCT TCACGCCGGT GACGTCGAAC AGGTCATCGG CGGTTGCGTG ACCCAGTTCG GGGAGCAATC CAACAACATC AGCCGGGTGG CCTGGCTGAC GGCCGGTTTG CCCGAACACG TCGGCGCCAC CACCGTCGAC TGCCAGTGCG GCAGCGGCCA GCAGGCCAAC CATCTGATTG CCGGGTTGAT CGCGGCCGGT GCCATCGATG TCGGCATCGC CTGCGGCATC GAGGCGATGA GCCGGGTCGG GCTGGGCGCC AACGCCGGGC CGGACCGCTC GCTGATCCGC GCGCAGTCAT GGGATATCGA CCTGCCGAAC CAGTTCGAGG CCGCCGAGCG GATCGCCAAG CGGCGCGGCA TCACCCGCGA GGACGTGGAT GTCTTCGGGC TCGAGTCGCA GCGACGCGCG CAGCGGGCCT GGGCGGAGGG CCGCTTTGAC CGCGAGATCT CGCCGATCCA GGCGCCGGTG CTCGACGAGC AGAATCAGCC CACCGGCGAG CGGCGCCTGG TCTTTCGCGA CCAGGGCCTG CGCGAGACCA CGATGGCGGG GCTAGGCGAG CTGAAACCGG TGCTCGAGGG CGGCATCCAC ACCGCGGGCA CGTCGTCGCA GATCTCCGAC GGCGCGGCAG CCGTGTTGTG GATGGACGAA GCCGTGGCAC GTGCGCACGG CCTGACCCCG CGGGCCCGGA TCGTCGCCCA GGCACTCGTC GGCGCCGAGC CCTACTACCA CCTGGACGGC CCGGTGCAGT CCACCGCGAA GGTGCTGGAG AAGGCCGGCA TGAAGATCGG CGACATCGAC ATCGTCGAGA TCAACGAGGC GTTCGCGTCC GTGGTGCTGT CCTGGGCGCG GGTGCACGAG CCCGACATGG ACCGGGTCAA CGTCAACGGC GGGGCGATCG CGCTGGGGCA TCCGGTGGGC TGCACCGGCA GCCGGCTGAT CACCACCGCC CTGCACGAGC TCGAGCGCAC CGACCAGAGC CTCGCGCTGA TCACCATGTG CGCCGGCGGG GCCCTGTCCA CCGGCACCAT CATCGAGCGG ATT

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