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Seattle Structural Genomics Center for Infectious Disease

MytuD.00725.a: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) Rv1011 (IspE)

Target Characteristics

from organism: Mycobacterium tuberculosis H37Rv
most recent status: cloned
center reference id: MytuD.00725.a
is community request: True
associated disease: Tuberculosis
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

External Resources

Resource Reference ID
OrthoMCL: OG5_130885
PATRIC ID: fig|83332.12.peg.1126
RefSeq: CAB08138
TubercuList: Rv1011
MTB Network Portal: Rv1011
UniProt: P9WKG7

Orthologues for Rv1011

Species % Identity % Coverage Clones Proteins Structures
marinum 91 99 1 0 0
ulcerans 91 99 1 0 0
avium 89 100 0 0 0
paratuberculosis 89 100 0 0 0
leprae 87 99 0 0 0
smegmatis 79 99 1 1 0
abscessus 76 100 1 1 3

Enzyme & Pathway Information

Pathway Pathway ID EC Number
methylerythritol phosphate pathway I NONMEVIPP-PWY 2.7.1.148
superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) PWY-5121 2.7.1.148
isoprene biosynthesis I PWY-6270 2.7.1.148
superpathway of ergosterol biosynthesis II PWY-7156 2.7.1.148
taxadiene biosynthesis (engineered) PWY-7392 2.7.1.148
methylerythritol phosphate pathway II PWY-7560 2.7.1.148

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MPTGSVTVRV PGKVNLYLAV GDRREDGYHE LTTVFHAVSL VDEVTVRNAD VLSLELVGEG ADQLPTDERN LAWQAAELMA EHVGRAPDVS IMIDKSIPVA GGMAGGSADA AAVLVAMNSL WELNVPRRDL RMLAARLGSD VPFALHGGTA LGTGRGEELA TVLSRNTFHW VLAFADSGLL TSAVYNELDR LREVGDPPRL GEPGPVLAAL AAGDPDQLAP LLGNEMQAAA VSLDPALARA LRAGVEAGAL AGIVSGSGPT CAFLCTSASS AIDVGAQLSG AGVCRTVRVA TGPVPGARVV SAPTEV

NT Sequence
gtgcccaccg ggtcggtcac cgttcgggtg cccggaaagg tcaacctcta tctggcggtc ggcgatcgcc gcgaggacgg ctatcacgag ctgaccacgg tatttcatgc cgtctcgctg gtcgacgagg taaccgttcg taacgctgat gtgctctcgc tcgagttggt cggcgagggg gccgaccagc tgccgaccga cgaacgcaat ctcgcctggc aggcggccga gctgatggcc gaacacgtgg gccgggcgcc ggacgtctcg atcatgatcg acaaatccat tccggtcgcc ggcggcatgg ccggtggcag cgcggacgct gcggcggtcc tggttgcgat gaactcgttg tgggaactca atgtgccccg ccgcgacctg cgcatgctcg ccgcgcggct aggcagcgat gtgccgtttg ccctgcatgg tggtaccgcg ctggggacgg gtcgcggcga ggagttggcc accgtgttat cccgcaacac cttccactgg gtcctggcgt tcgccgacag cgggttgctc acctccgcgg tgtacaacga gctcgaccgg ctcagggagg tgggggatcc gccccggctt ggtgagcccg ggccggttct ggctgcctta gctgcgggtg atccggatca gctggcgccg ttgctgggta atgaaatgca agcggccgcg gtgagcctgg acccggcgct ggctcgtgcg ttacgcgccg gtgtggaggc cggcgcgctc gcaggcatcg tgtccggttc gggtcccacg tgtgccttcc tgtgcacctc ggcgagctcg gcgatcgatg tcggcgcgca gctgtcgggg gcgggagttt gtcgcaccgt tcgagtcgcc accgggccgg tacccggcgc ccgcgtggtg tctgcgccga ccgaagtgtg a

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