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Seattle Structural Genomics Center for Infectious Disease

MytuD.00783.a: serine hydroxymethyltransferase

Target Characteristics

from organism: Mycobacterium tuberculosis H37Rv
most recent status: in PDB
center reference id: MytuD.00783.a
is community request: True
associated disease: Tuberculosis
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MytuD.00783.a.A1.GE25909 Full length( MytuD.00783.a ) 1 426 GE25909
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MytuD.00783.a.A1.PS00175a Full length( MytuD.00783.a ) 1 426
MytuD.00783.a.A1.PW26018 Full length( MytuD.00783.a ) 1 426

Structures

image of structure for 3H7F
3H7F
Deposited: 4/24/2009
Determination: XRay
Diffraction Image
Clone:
Protein: MytuD.00783.a.A1.PS00175
image of structure for 6ULD
6ULD
Deposited: 10/7/2019
Determination: XRay
Diffraction Image
Clone:
Protein: MytuD.00783.a.A1.PS00175

Publications by SSGCID

Increasing the structural coverage of tuberculosis drug targets.
Abendroth J, Abramov A, Armour B, Barrett LK, Baugh L, Begley DW, Buchko GW, Choi R, Clifton MC, Dieterich SH, Dranow DM, Edwards TE, Fairman JW, Ferrell M, Fox D, Gardberg AS, Hewitt SN, Lorimer D, Lyons-Abbott S, Mundt E, Muruthi MM, Myers J, Myler PJ, Napuli AJ, Phan I, Sekar A, Serbzhinskiy D, Stacy R, Staker BL, Stewart LJ, Taylor BM, Thompkins K, Tran N, Van Voorhis WC, Zhang Y
Tuberculosis (Edinb) - 2014
volume 95, issue 2, pages 142-8
PMID: 25613812; PMCID: PMC4361283
PDB: 3GVC, 3GVG, 3GWC, 3H7F, 3H81, 3HE2, 3HWI, 3HWK, 3HZG, 3ICO, 3KHP, 3LLS, 3MOY, 3MPZ, 3MYB, 3NDN, 3NDO, 3NF4, 3NG3, 3NJD, 3NWO, 3O0M, 3O38, 3OC6, 3OC7, 3OEC, 3OI9, 3OKS, 3OL3, 3OL4, 3OME, 3P0T, 3P2Y, 3P4I, 3P4T, 3P5M, 3P85, 3PE8, 3PGX, 3PK0, 3PPI, 3PXX, 3PZY, 3Q1T, 3Q8N, 3QBP, 3QDF, 3QH4, 3QHA, 3QIV, 3QK8, 3QKA, 3QLJ, 3QMJ, 3QRE, 3QUA, 3QUV, 3QXI, 3QXZ, 3QYR, 3R0O, 3R1I, 3R1J, 3R20, 3R2N, 3R4T, 3R6H, 3R6O, 3R7K, 3R8C, 3R9P, 3R9Q, 3R9R, 3R9S, 3R9T, 3RD5, 3RD7, 3RD8, 3RFQ, 3RIH, 3RR2, 3RR6, 3RRP, 3RRV, 3RSI, 3RV2, 3S55, 3S82, 3SBX, 3SF6, 3SLL, 3SVK, 3SVT, 3SWO, 3SWT, 3SWX, 3SX2, 3T3W, 3T7C, 3TAV, 3TCR, 3TDE, 3TJR, 3TL3, 3TLF, 3TRR, 3TSC, 3TX2, 3TZQ, 3TZU, 3U0A, 3U0B, 3UCX, 3UVE, 4DI1, 4DIE, 4DQ8, 4DXL, 4ED4, 4EGE, 4EGF, 4EMD, 4EO9, 4EYE, 4F3W, 4F47, 4FFC, 4GK6, 4HDT, 4HR3, 4I1Y, 4IJN, 4IV6, 4IZ9, 4J5I, 4KAM, 4LGV, 4O2D, 5EJ2

Citations by Others

Rare Sidechain Conformations in Proteins and DNA
BJ Hintze - 2015 - search.proquest.com
PDB: 3H7F
Phylogenetic framework and molecular signatures for the main clades of the phylum actinobacteria
B Gao, RS Gupta - Microbiology and Molecular Biology Reviews, 2012 - Am Soc Microbiol
cited by: 97 others
PDB: 3H7F
In vivo protein tyrosine nitration in Arabidopsis thaliana
J Lozano-Juste, R Colom-Moreno? - Journal of experimental botany, 2011 - Soc Experiment Biol
cited by: 10 others
PDB: 3H7F
Structural adaptation of serine hydroxymethyltransferase to low temperatures
A Siglioccolo, F Bossa, S Pascarella - International journal of biological Macromolecules, 2010 - Elsevier
cited by: 13 others
PDB: 3H7F

This list was obtained from Google Scholar searches using the Open Source tool https://github.com/ckreibich/scholar.py and each citation has been manually reviewed.

External Resources

Resource Reference ID
OrthoMCL: OG5_126679
PATRIC ID: fig|83332.12.peg.1224
RefSeq: YP_177787.1
TubercuList: Rv1093
MTB Network Portal: Rv1093
UniProt: P9WGI9

Orthologues for Rv1093

Species % Identity % Coverage Clones Proteins Structures
leprae 90 100 0 0 0
avium 89 100 0 0 0
paratuberculosis 88 100 0 0 0

Enzyme & Pathway Information

Pathway Pathway ID EC Number
N10-formyl-tetrahydrofolate biosynthesis 1CMET2-PWY 2.1.2.1
glycine biosynthesis I GLYSYN-PWY 2.1.2.1
formaldehyde assimilation I (serine pathway) PWY-1622 2.1.2.1
photorespiration PWY-181 2.1.2.1
folate polyglutamylation PWY-2161 2.1.2.1
folate transformations I PWY-2201 2.1.2.1
glycine betaine degradation I PWY-3661 2.1.2.1
glycine betaine degradation II (mammalian) PWY-3661-1 2.1.2.1
folate transformations II PWY-3841 2.1.2.1
purine nucleobases degradation II (anaerobic) PWY-5497 2.1.2.1
superpathway of L-serine and glycine biosynthesis I SER-GLYSYN-PWY 2.1.2.1

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MSAPLAEVDP DIAELLAKEL GRQRDTLEMI ASENFVPRAV LQAQGSVLTN KYAEGLPGRR YYGGCEHVDV VENLARDRAK ALFGAEFANV QPHSGAQANA AVLHALMSPG ERLLGLDLAN GGHLTHGMRL NFSGKLYENG FYGVDPATHL IDMDAVRATA LEFRPKVIIA GWSAYPRVLD FAAFRSIADE VGAKLLVDMA HFAGLVAAGL HPSPVPHADV VSTTVHKTLG GGRSGLIVGK QQYAKAINSA VFPGQQGGPL MHVIAGKAVA LKIAATPEFA DRQRRTLSGA RIIADRLMAP DVAKAGVSVV SGGTDVHLVL VDLRDSPLDG QAAEDLLHEV GITVNRNAVP NDPRPPMVTS GLRIGTPALA TRGFGDTEFT EVADIIATAL ATGSSVDVSA LKDRATRLAR AFPLYDGLEE WSLVGR

NT Sequence
ATGTCTGCCC CGCTCGCTGA GGTTGACCCC GATATCGCCG AGTTGCTGGC CAAGGAGCTT GGTCGGCAAC GAGACACCCT GGAGATGATC GCCTCGGAGA ACTTCGTACC GCGCGCTGTG CTGCAGGCCC AGGGCAGTGT GCTGACCAAC AAGTACGCCG AGGGACTGCC CGGGCGGCGC TACTACGGCG GTTGTGAGCA CGTCGACGTG GTGGAAAACC TCGCCCGCGA CCGAGCCAAG GCGTTGTTCG GTGCCGAATT CGCCAATGTG CAACCGCATT CGGGCGCTCA GGCCAACGCC GCGGTGCTGC ATGCGCTGAT GTCACCCGGC GAGCGGCTGT TGGGTCTGGA CCTGGCCAAC GGTGGTCACC TGACCCATGG CATGCGGCTG AACTTCTCCG GCAAGCTCTA CGAGAATGGC TTCTACGGCG TCGACCCGGC GACACATCTG ATCGACATGG ATGCGGTGCG GGCCACCGCA CTCGAATTCC GCCCGAAGGT GATCATCGCC GGCTGGTCGG CCTACCCGCG GGTGCTCGAC TTCGCGGCGT TCCGGTCGAT CGCCGACGAG GTCGGGGCCA AGTTGCTCGT GGACATGGCG CATTTCGCGG GTCTGGTCGC CGCGGGGTTG CACCCGTCGC CGGTGCCGCA CGCGGATGTG GTGTCCACCA CCGTGCACAA GACGCTCGGC GGCGGCCGCT CCGGCCTGAT CGTCGGTAAG CAGCAGTACG CCAAGGCGAT CAACTCGGCG GTGTTTCCCG GGCAGCAGGG CGGTCCGCTC ATGCACGTCA TTGCCGGCAA GGCGGTCGCG TTGAAGATCG CCGCCACACC CGAATTTGCC GACCGGCAGC GGCGCACGCT GTCCGGGGCC CGGATCATTG CCGATCGACT GATGGCTCCC GATGTCGCCA AGGCCGGTGT GTCGGTGGTC AGCGGCGGCA CCGACGTCCA CCTGGTGCTG GTCGATCTGC GTGATTCCCC ACTGGATGGC CAGGCCGCCG AGGACCTGCT GCACGAGGTC GGCATCACGG TCAACCGCAA CGCCGTCCCC AATGATCCCC GACCGCCGAT GGTGACCTCG GGCCTGCGGA TAGGCACGCC CGCGCTGGCG ACCCGCGGCT TCGGCGACAC CGAGTTCACC GAGGTCGCCG ACATTATTGC GACCGCGCTG GCGACCGGCA GTTCCGTTGA TGTGTCGGCG CTTAAGGATC GGGCGACCCG GCTGGCCAGG GCGTTTCCGC TCTACGACGG GCTCGAGGAG TGGAGTCTGG TCGGCCGC

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