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Seattle Structural Genomics Center for Infectious Disease

MytuD.01212.a: Malate dehydrogenase

Target Characteristics

from organism: Mycobacterium tuberculosis H37Rv
most recent status: purified
center reference id: MytuD.01212.a
is community request: False
associated disease: Tuberculosis
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MytuD.01212.a.A1.GE25949 Full length( MytuD.01212.a ) 1 329 GE25949
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MytuD.01212.a.A1.PS00155 Full length( MytuD.01212.a ) 1 329

External Resources

Resource Reference ID
OrthoMCL: OG5_127410
PATRIC ID: fig|83332.12.peg.1389
RefSeq: NP_215756.1
TubercuList: Rv1240
MTB Network Portal: Rv1240
UniProt: P9WK13

Orthologues for Rv1240

Species % Identity % Coverage Clones Proteins Structures
marinum 94 100 1 0 0
ulcerans 93 100 0 0 0
paratuberculosis 92 100 1 0 0
avium 91 100 1 1 0
leprae 89 100 1 0 0

Enzyme & Pathway Information

Pathway Pathway ID EC Number
respiration (anaerobic) ANARESP1-PWY 1.1.1.37
mixed acid fermentation FERMENTATION-PWY 1.1.1.37
gluconeogenesis I GLUCONEO-PWY 1.1.1.37
superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass GLYCOLYSIS-TCA-GLYOX-BYPASS 1.1.1.37
glyoxylate cycle GLYOXYLATE-BYPASS 1.1.1.37
L-aspartate degradation II MALATE-ASPARTATE-SHUTTLE-PWY 1.1.1.37
TCA cycle IV (2-oxoglutarate decarboxylase) P105-PWY 1.1.1.37
pyruvate fermentation to propanoate I P108-PWY 1.1.1.37
reductive TCA cycle I P23-PWY 1.1.1.37
incomplete reductive TCA cycle P42-PWY 1.1.1.37
formaldehyde assimilation I (serine pathway) PWY-1622 1.1.1.37
L-carnitine degradation III PWY-3641 1.1.1.37
L-glutamate degradation VIII (to propanoate) PWY-5088 1.1.1.37
reductive TCA cycle II PWY-5392 1.1.1.37
superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle PWY-5464 1.1.1.37
superpathway of glyoxylate cycle and fatty acid degradation PWY-561 1.1.1.37
TCA cycle II (plants and fungi) PWY-5690 1.1.1.37
partial TCA cycle (obligate autotrophs) PWY-5913 1.1.1.37
Methanobacterium thermoautotrophicum biosynthetic metabolism PWY-6146 1.1.1.37
TCA cycle III (animals) PWY66-398 1.1.1.37
gluconeogenesis III PWY66-399 1.1.1.37
methylaspartate cycle PWY-6728 1.1.1.37
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase) PWY-6969 1.1.1.37
malate-oxaloacetate shuttle I PWY-7047 1.1.1.37
malate-oxaloacetate shuttle II PWY-7048 1.1.1.37
C4 photosynthetic carbon assimilation cycle, NAD-ME type PWY-7115 1.1.1.37
chitin degradation to ethanol PWY-7118 1.1.1.37
anaerobic energy metabolism (invertebrates, cytosol) PWY-7383 1.1.1.37
anaerobic energy metabolism (invertebrates, mitochondrial) PWY-7384 1.1.1.37
superpathway of anaerobic energy metabolism (invertebrates) PWY-7389 1.1.1.37
TCA cycle I (prokaryotic) TCA 1.1.1.37
superpathway of glyoxylate bypass and TCA TCA-GLYOX-BYPASS 1.1.1.37

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MSASPLKVAV TGAAGQIGYS LLFRLASGSL LGPDRPIELR LLEIEPALQA LEGVVMELDD CAFPLLSGVE IGSDPQKIFD GVSLALLVGA RPRGAGMERS DLLEANGAIF TAQGKALNAV AADDVRVGVT GNPANTNALI AMTNAPDIPR ERFSALTRLD HNRAISQLAA KTGAAVTDIK KMTIWGNHSA TQYPDLFHAE VAGKNAAEVV NDQAWIEDEF IPTVAKRGAA IIDARGASSA ASAASATIDA ARDWLLGTPA DDWVSMAVVS DGSYGVPEGL ISSFPVTTKG GNWTIVSGLE IDEFSRGRID KSTAELADER SAVTELGLI

NT Sequence
GTGAGCGCTA GTCCTCTCAA GGTCGCCGTT ACCGGCGCCG CCGGCCAAAT CGGCTACAGC CTGTTGTTCC GCCTGGCCAG CGGCTCTTTG CTGGGCCCTG ACCGTCCGAT CGAGCTGCGG CTGCTCGAGA TCGAGCCGGC ACTGCAGGCG CTCGAGGGTG TGGTGATGGA ACTCGACGAC TGCGCTTTCC CGCTGTTGTC CGGGGTGGAG ATCGGTTCCG ATCCCCAGAA GATCTTCGAT GGTGTGAGCC TGGCCCTGCT GGTCGGAGCC CGCCCCCGGG GCGCGGGCAT GGAGCGAAGT GACCTGCTGG AGGCCAACGG CGCGATCTTC ACCGCTCAGG GCAAAGCCCT CAACGCTGTC GCCGCGGATG ACGTTCGCGT CGGGGTGACC GGCAACCCCG CCAACACCAA CGCGCTGATC GCGATGACCA ATGCGCCCGA CATTCCCCGC GAGCGGTTCT CGGCGCTCAC CCGGCTGGAC CACAATCGGG CGATCTCGCA GCTGGCCGCC AAGACCGGCG CGGCGGTCAC CGACATCAAG AAGATGACGA TCTGGGGCAA TCACTCGGCC ACCCAGTACC CCGACCTGTT CCACGCGGAG GTCGCCGGAA AGAACGCGGC CGAAGTGGTC AACGACCAGG CCTGGATCGA GGATGAATTC ATCCCGACGG TCGCCAAGCG CGGTGCGGCG ATCATCGATG CGCGCGGCGC GTCGTCGGCC GCCTCGGCCG CGTCGGCAAC CATCGACGCT GCCCGGGACT GGTTGCTGGG GACGCCGGCG GACGATTGGG TCTCGATGGC CGTCGTCTCC GACGGGTCCT ACGGGGTGCC GGAGGGCTTG ATCTCCTCGT TTCCGGTCAC CACCAAGGGC GGCAACTGGA CGATCGTGAG CGGCTTGGAG ATCGACGAGT TCTCCCGCGG CCGGATCGAC AAGTCAACCG CCGAGTTGGC TGACGAGCGC AGCGCGGTCA CCGAGCTCGG CCTGATC

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