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Seattle Structural Genomics Center for Infectious Disease

MytuD.10611.a: Probable zinc-dependent alcohol dehydrogenase AdhE2

Target Characteristics

from organism: Mycobacterium tuberculosis H37Rv
most recent status: soluble
center reference id: MytuD.10611.a
is community request: False
associated disease: Tuberculosis
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
MytuD.10611.a.MB1.GE30479 Full length( MytuD.10611.a ) 1 361 GE30479
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

External Resources

Resource Reference ID
OrthoMCL: OG5_142764
PATRIC ID: fig|83332.12.peg.2518
RefSeq: NP_216775.1
TubercuList: Rv2259
MTB Network Portal: Rv2259
UniProt: O53533

Orthologues for Rv2259

Species % Identity % Coverage Clones Proteins Structures
ulcerans 90 100 0 0 0
leprae 89 100 0 0 0
paratuberculosis 89 100 0 0 0
smegmatis 84 100 0 0 0
abscessus 83 96 1 0 0
marinum 32 97 1 0 0
ulcerans 32 97 1 0 0

Enzyme & Pathway Information

Pathway Pathway ID EC Number
L-homoserine biosynthesis HOMOSERSYN-PWY 1.1.1.3
superpathway of S-adenosyl-L-methionine biosynthesis MET-SAM-PWY 1.1.1.3
superpathway of L-homoserine and L-methionine biosynthesis METSYN-PWY 1.1.1.3
superpathway of L-lysine, L-threonine and L-methionine biosynthesis I P4-PWY 1.1.1.3
aspartate superpathway PWY0-781 1.1.1.3
superpathway of L-isoleucine biosynthesis I PWY-3001 1.1.1.3
superpathway of L-methionine biosynthesis (by sulfhydrylation) PWY-5345 1.1.1.3
superpathway of L-methionine biosynthesis (transsulfuration) PWY-5347 1.1.1.3
superpathway of L-lysine, L-threonine and L-methionine biosynthesis II PWY-724 1.1.1.3
superpathway of L-threonine biosynthesis THRESYN-PWY 1.1.1.3
formaldehyde oxidation III (mycothiol-dependent) PWY1G-170 1.1.1.306
methanol oxidation to carbon dioxide PWY-7616 1.1.1.306
formaldehyde oxidation V (bacillithiol-dependent) PWY-7908 1.1.1.306

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MSQTVRGVIA RQKGEPVELV NIVVPDPGPG EAVVDVTACG VCHTDLTYRE GGINDEYPFL LGHEAAGIIE AVGPGVTAVE PGDFVILNWR AVCGQCRACK RGRPRYCFDT FNAEQKMTLT DGTELTAALG IGAFADKTLV HSGQCTKVDP AADPAVAGLL GCGVMAGLGA AINTGGVTRD DTVAVIGCGG VGDAAIAGAA LVGAKRIIAV DTDDTKLDWA RTFGATHTVN AREVDVVQAI GGLTDGFGAD VVIDAVGRPE TYQQAFYARD LAGTVVLVGV PTPDMRLDMP LVDFFSHGGA LKSSWYGDCL PESDFPTLID LYLQGRLPLQ RFVSERIGLE DVEEAFHKMH GGKVLRSVVM L

NT Sequence
ATGAGTCAGA CGGTGCGCGG TGTGATCGCA CGACAAAAGG GCGAACCCGT TGAGCTGGTG AACATTGTCG TCCCGGATCC CGGACCCGGC GAGGCCGTGG TCGACGTCAC CGCCTGCGGG GTATGCCATA CCGACCTGAC CTACCGCGAG GGCGGCATCA ACGACGAATA CCCTTTTCTG CTCGGACACG AGGCCGCGGG CATCATCGAG GCCGTCGGGC CGGGTGTAAC CGCAGTCGAG CCCGGCGACT TCGTGATCCT GAACTGGCGT GCCGTGTGCG GCCAGTGCCG GGCCTGCAAA CGCGGACGGC CCCGCTACTG CTTCGACACC TTTAACGCCG AACAGAAGAT GACGCTGACC GACGGCACCG AGCTCACTGC GGCGTTGGGC ATCGGGGCCT TTGCCGATAA GACGCTGGTG CACTCTGGCC AGTGCACGAA GGTCGATCCG GCTGCCGATC CCGCGGTGGC CGGCCTGCTG GGTTGCGGGG TCATGGCCGG CCTGGGCGCC GCGATCAACA CCGGCGGGGT AACCCGCGAC GACACCGTCG CGGTGATCGG CTGCGGCGGC GTTGGCGATG CCGCGATCGC CGGTGCCGCG CTGGTCGGCG CCAAACGGAT CATCGCGGTC GACACCGATG ACACGAAGCT TGACTGGGCC CGCACCTTCG GCGCCACCCA CACCGTCAAC GCCCGCGAAG TCGACGTCGT CCAGGCCATC GGCGGCCTCA CGGATGGATT CGGCGCGGAC GTGGTGATCG ACGCCGTCGG CCGACCGGAA ACCTACCAGC AGGCCTTCTA CGCCCGCGAT CTCGCCGGAA CCGTTGTGCT GGTGGGTGTT CCGACGCCCG ACATGCGCCT GGACATGCCG CTGGTCGACT TCTTCTCTCA CGGCGGTGCG CTGAAGTCGT CGTGGTACGG CGATTGCCTG CCCGAAAGCG ACTTCCCCAC GCTGATCGAC CTTTACCTGC AGGGCCGGCT GCCGCTGCAG CGGTTCGTTT CCGAACGCAT CGGGCTCGAA GACGTCGAGG AGGCGTTCCA CAAGATGCAT GGCGGCAAGG TATTGCGTTC GGTGGTGATG TTG

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