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Seattle Structural Genomics Center for Infectious Disease

MytuD.17229.a: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 (IspH/LytB) (IspG/H)

Target Characteristics

from organism: Mycobacterium tuberculosis H37Rv
most recent status: selected
center reference id: MytuD.17229.a
is community request: True
associated disease: Tuberculosis
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

External Resources

Resource Reference ID
OrthoMCL: OG5_130373
PATRIC ID: fig|83332.12.peg.1242
RefSeq: NP_335584.1
TubercuList: Rv1110
MTB Network Portal: Rv1110
UniProt: P9WKG1

Enzyme & Pathway Information

Pathway Pathway ID EC Number
1.17.1.2
methylerythritol phosphate pathway I NONMEVIPP-PWY 1.17.7.4
superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) PWY-5121 1.17.7.4
isoprene biosynthesis I PWY-6270 1.17.7.4
superpathway of ergosterol biosynthesis II PWY-7156 1.17.7.4
taxadiene biosynthesis (engineered) PWY-7392 1.17.7.4
methylerythritol phosphate pathway II PWY-7560 1.17.7.4

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MVPTVDMGIP GASVSSRSVA DRPNRKRVLL AEPRGYCAGV DRAVETVERA LQKHGPPVYV RHEIVHNRHV VDTLAKAGAV FVEETEQVPE GAIVVFSAHG VAPTVHVSAS ERNLQVIDAT CPLVTKVHNE ARRFARDDYD ILLIGHEGHE EVVGTAGEAP DHVQLVDGVD AVDQVTVRDE DKVVWLSQTT LSVDETMEIV GRLRRRFPKL QDPPSDDICY ATQNRQVAVK AMAPECELVI VVGSRNSSNS VRLVEVALGA GARAAHLVDW ADDIDSAWLD GVTTVGVTSG ASVPEVLVRG VLERLAECGY DIVQPVTTAN ETLVFALPRE LRSPR

NT Sequence
atggttccga cggtcgacat ggggattccc ggggcttcgg tatcgtcgcg atcggtggcc gaccgtccca accgtaagcg ggtgctgctg gccgagccgc gtggctactg cgctggcgtg gatcgggccg tcgaaacggt cgaacgcgcg cttcaaaaac acggcccgcc tgtctacgtg cgtcacgaga tcgtgcataa ccgccacgtg gttgacaccc tggctaaggc cggtgcggtt ttcgtcgaag agaccgagca ggttcccgag ggagcgattg tggtgttctc cgcgcacggg gtcgcgccta cggtgcacgt cagcgccagc gagcgcaacc tgcaggtcat tgacgccacc tgcccgctgg tcaccaaggt gcacaacgag gccaggcggt tcgcccggga cgactacgac atcttgctga tcggtcatga gggccacgag gaagtcgtcg gtactgctgg ggaagctccc gatcatgtgc agctggtcga cggggtggac gccgtcgacc aggtgaccgt ccgtgacgag gacaaagtgg tttggctgtc gcagaccacc ctgtccgtcg atgagaccat ggagattgtc gggcggttgc gtcggcgttt ccccaagctg caggatccgc ccagcgacga catctgctat gcgacccaga atcggcaggt cgcggtcaag gcgatggcgc ccgagtgcga gctggtcatc gtggtcggct cgcgcaattc gtcgaattcg gttcggctgg tcgaggtggc gctgggtgcc ggggcgcggg ccgcccacct ggtggactgg gccgacgata tcgactcggc ctggctggac ggcgttacca cggtcggcgt tacgtcgggg gcatcggtcc ccgaggtgct ggtgcgcggt gtgctggagc ggctggccga atgcggctac gacatcgtgc aaccggtgac aacggccaac gagacgttgg tgttcgcatt gccccgggag ctccgctcac ctcgctga

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