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Seattle Structural Genomics Center for Infectious Disease

MytuD.17230.a: 1-deoxy-D-xylulose-5-phosphate synthase (DOXP/dxs/dxp)

Target Characteristics

from organism: Mycobacterium tuberculosis H37Rv
most recent status: selected
center reference id: MytuD.17230.a
is community request: True
associated disease: Tuberculosis
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

External Resources

Resource Reference ID
OrthoMCL: OG5_129068
PATRIC ID: fig|83332.12.peg.2992
RefSeq: NP_337257.1
TubercuList: Rv2682c
MTB Network Portal: Rv2682c
UniProt: P9WNS3

Enzyme & Pathway Information

Pathway Pathway ID EC Number
methylerythritol phosphate pathway I NONMEVIPP-PWY 2.2.1.7
superpathway of pyridoxal 5'-phosphate biosynthesis and salvage PWY0-845 2.2.1.7
superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) PWY-5121 2.2.1.7
isoprene biosynthesis I PWY-6270 2.2.1.7
thiazole biosynthesis II (aerobic bacteria) PWY-6891 2.2.1.7
thiazole biosynthesis I (facultative anaerobic bacteria) PWY-6892 2.2.1.7
superpathway of thiamine diphosphate biosynthesis II PWY-6895 2.2.1.7
superpathway of ergosterol biosynthesis II PWY-7156 2.2.1.7
taxadiene biosynthesis (engineered) PWY-7392 2.2.1.7
methylerythritol phosphate pathway II PWY-7560 2.2.1.7
pyridoxal 5'-phosphate biosynthesis I PYRIDOXSYN-PWY 2.2.1.7
superpathway of thiamine diphosphate biosynthesis I THISYN-PWY 2.2.1.7

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MLQQIRGPAD LQHLSQAQLR ELAAEIREFL IHKVAATGGH LGPNLGVVEL TLALHRVFDS PHDPIIFDTG HQAYVHKMLT GRSQDFATLR KKGGLSGYPS RAESEHDWVE SSHASAALSY ADGLAKAFEL TGHRNRHVVA VVGDGALTGG MCWEALNNIA ASRRPVIIVV NDNGRSYAPT IGGVADHLAT LRLQPAYEQA LETGRDLVRA VPLVGGLWFR FLHSVKAGIK DSLSPQLLFT DLGLKYVGPV DGHDERAVEV ALRSARRFGA PVIVHVVTRK GMGYPPAEAD QAEQMHSTVP IDPATGQATK VAGPGWTATF SDALIGYAQK RRDIVAITAA MPGPTGLTAF GQRFPDRLFD VGIAEQHAMT SAAGLAMGGL HPVVAIYSTF LNRAFDQIMM DVALHKLPVT MVLDRAGITG SDGASHNGMW DLSMLGIVPG IRVAAPRDAT RLREELGEAL DVDDGPTALR FPKGDVGEDI SALERRGGVD VLAAPADGLN HDVLLVAIGA FAPMALAVAK RLHNQGIGVT VIDPRWVLPV SDGVRELAVQ HKLLVTLEDN GVNGGAGSAV SAALRRAEID VPCRDVGLPQ EFYEHASRSE VLADLGLTDQ DVARRITGWV AALGTGVCAS DAIPEHLD

NT Sequence
atgctgcaac agatccgcgg gcccgctgat ctgcagcacc tttcccaggc gcagcttcgg gagctggccg ccgagatccg tgagttcctg atccacaagg ttgccgccac gggggggcat ctggggccga acctgggagt ggtggaactc accttggcgc tgcaccgggt attcgactcg ccgcacgatc cgatcatctt cgacaccggt caccaggcct acgtccacaa gatgttgacc ggacgcagcc aggacttcgc aaccctgcgt aagaagggcg ggttgtcggg gtatccgtct cgtgccgaga gcgagcacga ctgggtggag tcgagccacg ccagcgcggc gctgtcgtac gcggacgggt tggccaaggc gttcgagttg accggacacc gcaaccggca tgtggtcgcg gtggtcggtg acggtgcgct caccggcggt atgtgctggg aggcgctgaa caatatcgcc gcatcccgcc ggccggtgat tatcgtggtc aacgacaatg ggcgcagcta cgcgcccaca atcgggggcg tcgccgacca tctggccacg ctgcggctgc agccggccta cgagcaggcg ctggagacgg gccgcgacct ggtgcgcgcg gtgccgcttg tcggcggtct gtggtttcga ttcctgcaca gcgtcaaggc cggcatcaag gactcgctgt cgccgcagtt gctgttcacc gacctcgggt tgaagtacgt cggcccggtc gacggccatg acgagcgggc ggtggaggtc gcgctgcgca gcgcgcggcg cttcggtgca ccggtgatcg tgcacgtcgt cacccgcaag ggcatgggct acccgccggc cgaggccgac caggccgagc agatgcattc cacggtcccg atcgatccgg ccaccggaca agccaccaag gtggccggcc caggctggac ggcgaccttc tctgatgcac ttatcggcta cgcccagaaa cgccgtgaca tcgtggccat taccgcggcc atgccgggcc ccaccgggct gaccgcgttc gggcagcgct tcccggatcg attgttcgac gtcgggatcg ccgagcaaca cgcgatgacg tcggcggccg ggttggcgat gggtgggctg caccccgtgg tggcgatcta ctcgacgttc ctgaaccggg cgttcgacca gatcatgatg gatgtggcgc tgcacaagct gccggtcacc atggtgctgg accgtgccgg gatcaccggt agcgacggcg ccagccacaa cggaatgtgg gacttgtcga tgctgggtat cgtgcccggc atccgggtgg cagcgcccag agacgccacc cggttgcgtg aagaactcgg cgaggcgctc gacgtcgacg acggcccgac ggcgttacgg ttccccaaag gtgatgtggg agaagatatt tcggctttgg agcggcgtgg aggcgtggat gtgctggcgg cgcccgccga tggtttgaac cacgacgtcc tgttggtggc catcggcgcg ttcgcaccga tggcgttggc ggtggccaag cggctgcaca accaggggat cggtgtgacg gtgatcgacc cgcgctgggt gttgccggtg tctgacggtg tgcgcgaact ggcggtgcag cacaagctgc tcgtcacgct agaggacaac ggggtcaacg gtggggcggg gtcagcggtg tcggccgcgc tgcggcgcgc ggagatcgac gtgccctgcc gcgatgtcgg gttgccgcag gagttctacg agcacgcgtc tcgaagcgag gtgctggccg atctggggct taccgaccag gacgtggccc ggcggatcac cggctgggtc gccgcgctgg gtaccggggt gtgtgcgtcc gacgcgattc cagaacatct cgactaa

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