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Seattle Structural Genomics Center for Infectious Disease

MytuD.17231.a: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (IspG/GcpE) (IspG/H)

Target Characteristics

from organism: Mycobacterium tuberculosis H37Rv
most recent status: selected
center reference id: MytuD.17231.a
is community request: True
associated disease: Tuberculosis
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIIC

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

External Resources

Resource Reference ID
OrthoMCL: OG5_130276
PATRIC ID: fig|83332.12.peg.3198
RefSeq: NP_217384.1
TubercuList: Rv2868c
MTB Network Portal: Rv2868c
UniProt: P9WKG3

Enzyme & Pathway Information

Pathway Pathway ID EC Number
methylerythritol phosphate pathway II PWY-7560 1.17.7.1
methylerythritol phosphate pathway I NONMEVIPP-PWY 1.17.7.3
superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) PWY-5121 1.17.7.3
isoprene biosynthesis I PWY-6270 1.17.7.3
superpathway of ergosterol biosynthesis II PWY-7156 1.17.7.3
taxadiene biosynthesis (engineered) PWY-7392 1.17.7.3

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MTVGLGMPQP PAPTLAPRRA TRQLMVGNVG VGSDHPVSVQ SMCTTKTHDV NSTLQQIAEL TAAGCDIVRV ACPRQEDADA LAEIARHSQI PVVADIHFQP RYIFAAIDAG CAAVRVNPGN IKEFDGRVGE VAKAAGAAGI PIRIGVNAGS LDKRFMEKYG KATPEALVES ALWEASLFEE HGFGDIKISV KHNDPVVMVA AYELLAARCD YPLHLGVTEA GPAFQGTIKS AVAFGALLSR GIGDTIRVSL SAPPVEEVKV GNQVLESLNL RPRSLEIVSC PSCGRAQVDV YTLANEVTAG LDGLDVPLRV AVMGCVVNGP GEAREADLGV ASGNGKGQIF VRGEVIKTVP EAQIVETLIE EAMRLAAEMG EQDPGATPSG SPIVTVS

NT Sequence
gtgactgtag gcttgggcat gccgcagccc ccggcaccca cgctcgctcc ccggcgcgcc acccgtcagc tgatggtcgg caacgtcggc gtgggcagtg accatccggt ctcggtgcaa tcgatgtgca ccaccaaaac ccacgacgtc aactcgacat tgcaacaaat cgccgagctg accgcggccg gatgcgacat cgtgcgggtg gcctgcccgc gccaggagga cgccgacgcg ctggccgaga tcgcccggca cagccagatc ccggtagtcg cggacataca tttccagccg cgctacatat tcgccgccat cgacgctgga tgtgccgcgg tgcgggtcaa cccgggcaac atcaaggagt ttgacggccg ggtgggtgag gtcgccaagg cggcgggtgc ggccgggatc ccgatccgaa tcggtgtcaa cgccggttcg ctggacaaac ggttcatgga gaagtatggc aaagccacgc ccgaggcgct ggttgagtcg gcgctgtggg aggcttcgct tttcgaggag catggcttcg gtgacatcaa gatcagcgtc aagcacaacg acccggtggt gatggtcgcc gcctacgagc tgcttgctgc acggtgcgac tacccactgc acctcggtgt caccgaggcc ggccctgctt tccagggcac catcaagtcc gcggttgcct tcggcgcgtt gctgtcgcgg ggcataggcg acaccatccg ggtgtcgttg tcggccccgc cggtcgagga agtcaaggtg ggcaatcagg ttctcgagtc gttgaacctg cggccgcgtt cgctcgagat cgtgtcttgc ccgtcgtgcg gtcgcgcgca agtcgacgtc tacaccctgg ccaacgaggt aaccgccggc ctggatggtc tcgatgtgcc gttgcgggtg gccgtgatgg ggtgtgtcgt caatggtccg ggtgaagcac gtgaggccga cctgggcgtg gcgtccggca acggcaaagg tcagatcttt gtacggggcg aagtgatcaa gaccgtgccc gaagcacaga tcgtcgagac gctgatcgag gaggcgatgc ggctggccgc cgaaatgggc gagcaagatc cgggcgcgac accgagcggt tcgcctattg tgaccgtaag ctga

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